Therapeutic efficacy of hydrophilic gels of α-tocopherol and tretinoin in skin ulcers induced by adriamycin hydrochloride

Lucero, M.J.; Vigo, Jean; León, M.J.; Martin, F.; Sánchez, Jonatan

doi:10.1016/0378-5173(95)04132-x

Cited by 7 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compatibility of AgSD with fibroblasts and with the GFs of platelet lysate can be critical, but previous papers demonstrated that the AgSD encapsulated either in SLN or in chitosan oleate nanoparticles maintained its antimicrobial activity and improved its compatibility with PL GFs [ 26 , 30 ]. The relevance of αTph as antioxidant agent in the wound healing promotion has been suggested by the importance of the ROS regulation in chronic wounds as described in the literature [ 31 , 32 , 33 ]. In a recent study, a stimulating effect of αTphNE on fibroblast and keratinocyte proliferation was observed [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Alpha Tocopherol and Ag Sulfadiazine Chitosan Oleate Nanocarriers in Bioactive Dressings Supporting Platelet Lysate Application to Skin Wounds

et al. 2018

View full text Add to dashboard Cite

Chitosan oleate was previously proposed to encapsulate in nanocarriers some poorly soluble molecules aimed to wound therapy, such as the anti-infective silver sulfadiazine, and the antioxidant α tocopherol. Because nanocarriers need a suitable formulation to be administered to wounds, in the present paper, these previously developed nanocarriers were loaded into freeze dried dressings based on chitosan glutamate. These were proposed as bioactive dressings aimed to support the application to wounds of platelet lysate, a hemoderivative rich in growth factors. The dressings were characterized for hydration capacity, morphological aspect, and rheological and mechanical behavior. Although chitosan oleate nanocarriers clearly decreased the mechanical properties of dressings, these remained compatible with handling and application to wounds. Preliminary studies in vitro on fibroblast cell cultures demonstrated good compatibility of platelet lysate with nanocarriers and bioactive dressings. An in vivo study on a murine wound model showed an accelerating wound healing effect for the bioactive dressing and its suitability as support of the platelet lysate application to wounds.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of Alpha Tocopherol and Ag Sulfadiazine Chitosan Oleate Nanocarriers in Bioactive Dressings Supporting Platelet Lysate Application to Skin Wounds

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This can be attributed to the presence of active secondary metabolites including squalene and α-tocopherol in CPSCE for cell regeneration [33]. In addition, topical application of α-tocopherol and squalene have been reported to improve wound healing and skin regeneration [36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antioxidant and Cytoprotective Potentials of Carica papaya Leaf Extracts: A Comparison of Supercritical Fluid and Conventional Extraction Methods

et al. 2021

View full text Add to dashboard Cite

The leaves of Carica papaya (CP) are rich in natural antioxidants. Carica papaya has traditionally been used to treat various ailments, including skin diseases. This study aims to decipher the antioxidant effects and phytochemical content of different CP leaf extracts (CPEs) obtained using supercritical carbon dioxide (scCO2) and conventional extraction methods. The antioxidant activities of CPEs were evaluated by cell-free (1,1-diphenyl-2-picryl-hydrazyl (DPPH) and ferric-reduced antioxidative power (FRAP)) and cell-based (H2O2) assay. Both C. papaya leaf scCO2 extract with 5% ethanol (CPSCE) and C. papaya leaf scCO2 extract (CPSC) exhibited stronger DPPH radical scavenging activity than conventional extracts. In the FRAP assay, two hydrophilic extracts (C. papaya leaf ethanol extract (CPEE) and C. papaya freeze-dried leaf juice (CPFD)) showed relatively stronger reducing power compared to lipophilic extracts. Cell-based assays showed that CPFD significantly protected skin fibroblasts from H2O2-induced oxidative stress in both pre-and post-treatment. CPEE protected skin fibroblasts from oxidative stress in a dose-dependent manner while CPSCE significantly triggered the fibroblast recovery after treatment with H2O2. GC-MS analysis indicated that CPSCE had the highest α-tocopherol and squalene contents. By contrast, both CP hydrophilic extracts (CPEE and CPFD) had a higher total phenolic content (TPC) and rutin content than the lipophilic extracts. Overall, CPEs extracted using green and conventional extraction methods showed antioxidative potential in both cell-based and cell-free assays due to their lipophilic and hydrophilic antioxidants, respectively.

show abstract

Anti-inflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitis

Bitencourt

Silva

Abílio

et al. 2015

Revista Brasileira de Farmacognosia

View full text Add to dashboard Cite

Therapeutic efficacy of hydrophilic gels of α-tocopherol and tretinoin in skin ulcers induced by adriamycin hydrochloride

Cited by 7 publications

References 25 publications

Association of Alpha Tocopherol and Ag Sulfadiazine Chitosan Oleate Nanocarriers in Bioactive Dressings Supporting Platelet Lysate Application to Skin Wounds

Association of Alpha Tocopherol and Ag Sulfadiazine Chitosan Oleate Nanocarriers in Bioactive Dressings Supporting Platelet Lysate Application to Skin Wounds

Chemical Composition, Antioxidant and Cytoprotective Potentials of Carica papaya Leaf Extracts: A Comparison of Supercritical Fluid and Conventional Extraction Methods

Anti-inflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitis

Contact Info

Product

Resources

About