Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Johnson, Athira; Kong, Fanbin; Miao, Song; Lin, Hong‐Ting Victor; Thomas, Sabu; Huang, Yi‐Cheng; Kong, Zwe‐Ling

doi:10.1038/s41598-020-74845-9

Cited by 60 publications

(34 citation statements)

References 100 publications

(114 reference statements)

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“…Therefore, this is also a good model reference for bone repair after maxillofacial tumour treatment. In addition to these materials, hydrogels with multiple functions (including anti-inflammatory effects 132 , antibacterial effects 133 , tumour treatment 134 , tissue repair 135 , etc.) have long been applied, and injectable hydrogels have to potential to reach the targeted area without surgical harm.…”

Section: Biomaterial-mediated Antitumour/bone Repair Strategiesmentioning

confidence: 99%

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

et al. 2021

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Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable tumour recurrence, and metastasis are major threats to the patients’ lives in the clinic. Fortunately, biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis, suggesting new promising antitumour therapies. In addition, maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients, and investment in treatment can result in a multitude of burdens to society. Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration. More interestingly, an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option. Herein, we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair. Furthermore, we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

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Section: Biomaterial-mediated Antitumour/bone Repair Strategiesmentioning

confidence: 99%

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

et al. 2021

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“…Interestingly, a local drug carrier for diabetics’ periodontitis therapy is a glucose-sensitive CS-poly(ethylene oxide) (PEO) hydrogel of a semi-interpenetrated type, which can release metronidazole at a higher glucose concentration and has a great capacity to inhibit Porphyromonas gingivalis [ 46 ]. Using the same cross-linking agent, mesoporous hydroxyapatite/CS biocomposite hydrogels loaded with recombinant human amelogenin were obtained; they can inhibit the growth of periodontal pathogens and promote the formation of bone and cementum-like tissue [ 47 ].…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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“…By adding osteo-inductive drug compounds, such an approach combines several stimulatory principles, thereby enhancing the bone regenerative capacity of the material [315]. Another recently published article presents a cellulose/κ-carrageenan oligosaccharid-based hydrogel with incorporated antimicrobial agents, which showed strong antibacterial activities in a periodontitis model [316]. As there is a vastly growing amount of such applications, the interested reader is referred to some recent, innovate research work, which cannot be discussed in detail here [317][318][319][320][321].…”

Section: May the Force Be With You: Mt And Its Implications For Periodontal Regenerationmentioning

confidence: 99%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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Among oral tissues, the periodontium is permanently subjected to mechanical forces resulting from chewing, mastication, or orthodontic appliances. Molecularly, these movements induce a series of subsequent signaling processes, which are embedded in the biological concept of cellular mechanotransduction (MT). Cell and tissue structures, ranging from the extracellular matrix (ECM) to the plasma membrane, the cytosol and the nucleus, are involved in MT. Dysregulation of the diverse, fine-tuned interaction of molecular players responsible for transmitting biophysical environmental information into the cell’s inner milieu can lead to and promote serious diseases, such as periodontitis or oral squamous cell carcinoma (OSCC). Therefore, periodontal integrity and regeneration is highly dependent on the proper integration and regulation of mechanobiological signals in the context of cell behavior. Recent experimental findings have increased the understanding of classical cellular mechanosensing mechanisms by both integrating exogenic factors such as bacterial gingipain proteases and newly discovered cell-inherent functions of mechanoresponsive co-transcriptional regulators such as the Yes-associated protein 1 (YAP1) or the nuclear cytoskeleton. Regarding periodontal MT research, this review offers insights into the current trends and open aspects. Concerning oral regenerative medicine or weakening of periodontal tissue diseases, perspectives on future applications of mechanobiological principles are discussed.

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Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Cited by 60 publications

References 100 publications

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

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