Therapeutic effect of the alkaloid extract of the cyanobacterium Spirulina platensis on the lipid profile of hypercholesterolemic male rabbits

Kata, Faris S.; Athbi, Ahmed M.; Manwar, Entisar Q; Al-Ashoor, Ahmed; Abdel-Daim, Mohamed M.; Aleya, Lotfi

doi:10.1007/s11356-018-2170-4

Cited by 26 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 37 , 38 Antioxidants now play a significant role in preventing the accumulation of lipids in blood vessels by eliminating the lipid peroxides derived through lipid peroxidation and free radicals. 39 According to the clinical practice guidelines, LDL-C is considered to be the main target for lipid-lowering treatment, with a 1% reduction associated with a 1% decrease in CVD events. 40 The lipid-modifying effects of spirulina were established in our present meta-analysis, especially on TC, LDL-C, and TG.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure

Huang¹,

Liao²,

Pu³

et al. 2018

DMSO

View full text Add to dashboard Cite

PurposeSpirulina is generally used as a nutraceutical food supplement due to its nutrient profile, lack of toxicity, and therapeutic effects. Clinical trials have investigated the influence of spirulina on metabolic-related risk factors but have yielded conflicting results in humans. Here, we summarize the evidence of the effects of spirulina on serum lipid profile, glucose management, BP, and body weight by conducting a meta-analysis.Materials and methodsRelevant studies were retrieved by systematic search of MEDLINE, EMBASE, Scopus databases, and reference lists of relevant original studies from inception to July 2018. Data were extracted following a standardized protocol. Two investigators independently extracted study characteristics, outcomes measures, and appraised methodological quality. Effect sizes were performed using a random-effects model, with weighted mean differences (WMDs) and 95% CIs between the means for the spirulina intervention and control arms. Subgroup analyses were conducted to explore the possible influences of study characteristics. Publication bias and sensitivity analysis were also performed.ResultsA total of 1,868 records were identified of which 12 trials with 14 arms were eligible. The amount of spirulina ranged from 1 to 19 g/d, and intervention durations ranged from 2 to 48 weeks. Overall, data synthesis showed that spirulina supplements significantly lowered total cholesterol (WMD = −36.60 mg/dL; 95% CI: −51.87 to −21.33; P=0.0001), low-density lipoprotein cholesterol (WMD = −33.16 mg/dL; 95% CI: −50.52 to −15.75; P=0.0002), triglycerides (WMD = −39.20 mg/dL; 95% CI: −52.71 to −25.69; P=0.0001), very-low-density lipoprotein cholesterol (WMD = −8.02 mg/dL; 95% CI: −8.77 to −7.26; P=0.0001), fasting blood glucose (WMD = −5.01 mg/dL; 95% CI: −9.78 to −0.24; P=0.04), and DBP (WMD = −7.17 mmHg; 95% CI: −8.57 to −5.78; P=0.001). These findings remained stable in the sensitivity analysis, and no obvious publication bias was detected.ConclusionOur findings provide substantial evidence that spirulina supplementation has favorable effect on select cardiovascular and metabolic biomarkers in humans, including lipid, glucose, and DBP management.

show abstract

Section: Discussionmentioning

confidence: 99%

Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure

Huang¹,

Liao²,

Pu³

et al. 2018

DMSO

View full text Add to dashboard Cite

show abstract

“…Also, allicin can prevent apoptosis of rats by activating extracellular signal‐regulated kinase (Abdel‐Daim, Kilany, Khalifa, & Ahmed, ). Generally, phytochemicals enhance immune responses, reduce blood lipid profile and lipid accumulation (Abdelnour et al, ; Kata et al, ) and regulate the enzyme activity of glycolytic and gluconeogenic processes in the liver rats (Chetna et al, ).…”

Section: Introductionmentioning

confidence: 99%

Influence of allicin administration on reproductive efficiency, immunity and lipid peroxidation of rabbit does under high ambient temperature

El‐Ratel

Abdel‐Khalek

Gabr

et al. 2020

Animal Physiology Nutrition

View full text Add to dashboard Cite

This study investigated the effect of daily oral administration with allicin levels (0, 5 and 10 mg/kg of female body weight), 30 days pre‐insemination, on reproductive performance in vivo and in vitro, immunity, and oxidative stress of rabbit does under high ambient temperature. Niliparous NZW does (n = 105) were randomly divided into three groups (35 in each) treated with 0, 5 and 10 mg allicin dissolved in 2 ml distilled water, respectively, for 30 days pre‐insemination. At the end of treatment (30 days), does were artificially inseminated with fresh diluted semen of 20 fertile NZW bucks. Reproductive performance and ovulatory response parameters were determined. Serum biochemicals, enzyme activity, immunoglobulins (IgG and IgM) and antioxidant status were determined on day 30 of treatment. Serum progesterone and prolactin were determined pre‐insemination (30 days of treatment), on 15 days of pregnancy and 7 days post‐partum. Results showed that both allicin levels increased live litter size, and bunny viability rat and litter size at birth and weaning. Allicin levels increased ovulation rate and improved embryo quality. Number of total follicles decreased only with 10 mg allicin. Progesterone increased pre‐insemination, 15 days of pregnancy and 7 days post‐partum progesterone by allicin levels. Prolactin pre‐insemination and on day 7 post‐partum increased with 10 mg allicin. Serum total proteins, albumin, globulin, IgG and IgM increased, while glucose, aspartate and alanine aminotransaminases, and thiobarbituric acid reaction decreased by both allicin levels. In conclusion, the mechanism by which allicin administration 30 days pre‐insemination to improve the reproductive performance of rabbit does is based on that allicin can play an important role, as a natural exogenous antioxidant, increasing immune response and reducing lipid peroxidation.

show abstract

“…Photoautotrophic microscopic organisms include a large variety of species of widespread occurrence and with diverse morphological, physiological, and biochemical properties (Kata et al, 2018). Among these organisms, cyanobacteria occupy all types of habitats as they are able to overcome a plethora of environmental constraints, including cold, drought, salinity, photo-oxidation, anaerobiosis, osmotic pressure, and exposure to UV radiations (Samarakoon and Jeon, 2012;Moscoso et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Biochemical analysis of cyanobacterial strains isolated from different Tunisian inland waters: therapeutical and nutritional potential

Gharbi¹,

Fathalli²,

Fassatoui³

et al. 2019

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

The last decade period has been characterized by a remarkable increase in the need for food, bioenergy, and pharmaceutical compounds. Meanwhile, microalgae have been in the center of interest as a rich and sustainable source of highly valuable natural products and bioactive compounds. In this perspective, the present study aimed at investigating the biochemical composition of 10 cyanobacterial strains collected from several Tunisian inland waters, seeking to identify the possible use of cyanobacteria in nutraceuticals and pharmaceuticals industry, and for animal and human consumption. Ten local strains of cyanobacteria were isolated from several Tunisian inland waters and cultured in controlled laboratory conditions. Fatty Acid methyl esters were analyzed in each strain by Gas chromatography-Mass spectrometry (GC-MS) as well as total proteins, carbohydrates and different phycobiliproteins (phycocyanin, allophycocyanin and phycoerythrin). Results showed that Planktothrix agardhii, Leptolyngbya sp1., and Leptolyngbya sp2. contained 14 different fatty acids, among which oleic acid was the most abundant. These might be important in nutraceutical and agronomic sectors due to the potent antioxidant and larvicidal activities of oleic acid. Cylindrospermopsis raciborskii presents extraordinarily high levels of phycocyanin, making it an exceptional natural reservoir of effective and non-toxic drugs that are of particular interest against cancer and neurodegenerative diseases. Extracts from cyanobacterial strains represent a natural and available source of proteins, of highly valuable fatty acids, and especially of phycocyanin which is known by its extremely health beneficial properties. The nutritional and functional complements provided by these extracts can be used in the prevention of various diseases and also as effective and environmentally friendly insecticides.

show abstract

Therapeutic effect of the alkaloid extract of the cyanobacterium Spirulina platensis on the lipid profile of hypercholesterolemic male rabbits

Cited by 26 publications

References 39 publications

Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure

Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure

Influence of allicin administration on reproductive efficiency, immunity and lipid peroxidation of rabbit does under high ambient temperature

Biochemical analysis of cyanobacterial strains isolated from different Tunisian inland waters: therapeutical and nutritional potential

Contact Info

Product

Resources

About