Therapeutic effect of lycopene-rich tomato juice on cardiac disorder in rats fed on fried food in oxidized frying oil

A, Hassan H.; Edrees, G.M.

doi:10.21608/ejhm.2004.18226

Cited by 12 publications

(2 citation statements)

References 35 publications

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“…Some in vivo and clinical studies also prove the efficacy of lycopene in cardiovascular disease prevention, as shown in Tables 3 and 4 . For example, an animal study reported that lycopene attenuated oxidized frying oil‐mediated cardiac disorders by reducing the levels of lipid fractions, LDL‐C, increasing HDL‐C levels, and restricting the hyperactivity of heart enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) (Hassan & Edrees, 2004 ). In addition, a few studies on New Zealand rabbits demonstrated that lycopene significantly prevented the risk factors for cardiovascular diseases, including atherosclerosis, by regulating serum lipid profile, improving LDL/HDL ratio, total antioxidant capacity (TAC), and ApoB levels, inhibiting atherosclerotic plaque formation, hepatic HMG‐CoA reductase activities, and reducing ApoA1, IL‐1 and MDA levels (Table 3 ) (Hu et al, 2008 ; Lorenz et al, 2012 ; Verghese et al, 2008 ).…”

Section: Potentials Of Lycopene Against Aging Biomarkers and Aging‐re...mentioning

confidence: 99%

Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

Abir

Mahamud

Tonny

et al. 2023

Food Science & Nutrition

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Aging and aging‐related chronic disorders are one of the principal causes of death worldwide. The prevalence of these disorders is increasing gradually and globally. Considering this unwavering acceleration of the global burden, seeking alternatives to traditional medication to prevent the risk of aging disorders is needed. Among them, lycopene, a carotenoid, is abundant in many fruits and vegetables, including tomatoes, grapefruits, and watermelons, and it has a unique chemical structure to be a potent antioxidant compound. This nutraceutical also possesses several anti‐aging actions, including combating aging biomarkers and ameliorating several chronic disorders. However, no systematic evaluation has yet been carried out that can comprehensively elucidate the effectiveness of lycopene in halting the course of aging and the emergence of chronic diseases linked to aging. This review, therefore, incorporates previous pre‐clinical, clinical, and epidemiological studies on lycopene to understand its potency in treating aging disorders and its role as a mimic of caloric restriction. Lycopene‐rich foods are found to prevent or attenuate aging disorders in various research. Based on the evidence, this review suggests the clinical application of lycopene to improve human health and alleviate the prevalence of aging and aging disorders.

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Section: Potentials Of Lycopene Against Aging Biomarkers and Aging‐re...mentioning

confidence: 99%

Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

Abir

Mahamud

Tonny

et al. 2023

Food Science & Nutrition

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“…Many reports describe the beneficial role of lycopene in the endothelial activity of nitric oxide synthase and the normalization of nitric oxide levels in coronary arteries, blockage of the mevalonate pathway of cholesterol biosynthesis, and recuperation of endothelial function and inflammatory damage[60]. In their 2004 study on rats, Hassan and Edrees demonstrated that biochemical alterations in the activities of heart-specific enzymes LDL, CK, ALT, and AST caused by the consumption of oxidized frying cottonseed oil were ameliorated when lycopene was added to their diets[61]. Plasma lycopene levels and conjugated dienes, primary products of lipid oxidation, have a significant negative correlation.…”

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confidence: 99%

Risk reduction and prevention of cardiovascular diseases: biological mechanisms of lycopene

Rejali¹,

Ozumerzifon²,

Nayeri³

et al. 2022

BCHD

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Background and aims: The conservational effects of dietary interventions as advantageous instruments in the primary and secondary prevention of cardiovascular disease (CVD) have gotten more attention in recent years. Numerous nutritional epidemiological studies have highlighted the ability of diets to decrease costly care and treatments as well as adverse side effects from standard treatments. Lycopene is a non-pro-vitamin A carotenoid that is present in tomatoes, processed tomato products, and different fruits like watermelon, autumn olive, gac, pink grapefruit, pink guava, papaya, sea buckthorn, and wolfberry. As one of the most powerful antioxidants among dietary tetraterpenoids, lycopene can also assist in lowering the risk of early death and extending life in patients with heart disease. By reducing the destructive effects of free radicals along with total and “bad” LDL cholesterol levels while increasing “good” HDL cholesterol, lycopene holds the power to reduce the risk factors of heart disease. Several studies have investigated a reduction of oxidized-LDL (oxLDL) cholesterol levels following lycopene consumption which supports these claims and suggests the conceivable function of lycopene in the blockage of oxidative stress-associated CVD. A negative correlation between serum lycopene concentration and mortality of people with metabolic syndrome was found. Over 10 years, researchers observed a 39% decreased chance of premature death in individuals with the metabolic disease who had the highest blood concentrations of lycopene. Lycopene’s protective impacts are especially beneficial in those with low blood antioxidant levels or high levels of oxidative stress. This includes older adults, smokers, and diabetic individuals or other vascular disorders. Lycopene intake has been thought to reduce the risk of obesity, insulin resistance, and diabetes mellitus.Lycopene acts as an antihypertensive agent by impeding the angiotensin-converting enzyme and improving the production of nitric oxide (NO) in the endothelium. The purpose of this review is to summarize the possible mechanisms of lycopene in the prevention of CVD. Keywords: Lycopene, Risk factors of heart disease, Antioxidants, Carotenoids, Cardio-metabolic, Insulin resistance

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Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

Soltani

Boozari

Cicero

et al. 2021

Phytotherapy Research

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High‐density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol efflux, are associated with cardiovascular disease rather than HDL levels. We have reviewed the evidence base on the major classes of phytochemicals, including polyphenols, alkaloids, carotenoids, phytosterols, and fatty acids, and their effects on macrophage cholesterol efflux and its major pathways. Phytochemicals show the potential to improve the efficiency of each of these pathways. The findings are mainly in preclinical studies, and more clinical research is warranted in this area to develop novel clinical applications.

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Therapeutic effect of lycopene-rich tomato juice on cardiac disorder in rats fed on fried food in oxidized frying oil

Cited by 12 publications

References 35 publications

Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

Risk reduction and prevention of cardiovascular diseases: biological mechanisms of lycopene

Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

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