Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

Soltani, Saeid; Boozari, Motahareh; Cicero, Arrigo F G; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1002/ptr.6991

Cited by 59 publications

(29 citation statements)

References 198 publications

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“…Therefore, stabilizing the mitochondria can prevent doxorubicin-induced cardiotoxicity ( Montaigne et al, 2010 ). Indeed, recent studies have reported that natural products may be appropriate alternatives for chemical agents in various diseases ( Momtazi et al, 2017 ; Bagherniya et al, 2018 ; Alidadi et al, 2020 ; Soltani et al, 2021 ). One such natural product, R. turkestanicum , belongs to the Polygonaceae family and is composed of active ingredients with various pharmacological and biochemical properties ( Ghorbani et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

et al. 2022

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Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum turkestanicum (R.turkestanicum) extract against doxorubicin cardiotoxicity due to its considerable in vitro antioxidant activity.Methods: Male Wistar rats received 2.5 mg/kg doxorubicin intraperitoneally every other day for 2 weeks to create an accumulative dose. R. turkestanicum was administrated at a dose of 100 and 300 mg/kg intraperitoneally from the second week for 7 days. On the 15th day, the animals were anesthetized and blood was collected from cardiac tissue for evaluation of alanine aminotransferase (ALT), cardiac muscle creatinine kinase (CK-MB), troponin T (cTn-T), lactate dehydrogenase (LDH), and B-type natriuretic peptide brain natriuretic peptide. A cardiac homogenate was also collected to determine superoxide dismutase (SOD), catalase Catalase Activity, malondialdehyde (MDA), and thiols. Histopathology was also performed.Results: Doxorubicin increased all cardiac enzymes and malondialdehyde, correlating with a reduction in SOD, catalase, and thiols. Histopathology revealed extracellular edema, moderate congestion, and hemorrhage of foci. In contrast, administration of R. turkestanicum ameliorated these doxorubicin-induced pathophysiological changes.Conclusion: This study revealed that the extract ameliorated doxorubicin-induced cardiac toxicity via modulation of oxidative stress-related pathways. Liquid chromatography-mass spectrometry analysis of R. turkestanicum indicated several components with potent pharmacological properties.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

et al. 2022

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“…The andrographolide effect in stimulating the immune system in the body, and especially phagocytic activity that stimulates the production and flow of bile, protects the hepar from toxins, against the damage effects caused by free radicals. Andrographolide also showed protective activity in the fight against chemical-induced toxicity (Polash et al 2017;Soltani et al 2021;Rachmani E. 2019). APL serves as an appetite enhancer, but high doses of APL can result in nausea vomiting, bad stomach and loss of appetite (Mustafa et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Effect of Sambiloto (Andrographis paniculata) Leaves against Cholesterol Levels in Wistar Rats with Atherogenic Diet

Laili

Alristina

Ethasari

et al. 2021

IJALSR

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Introduction : The risk of atherosclerosis increases when elevated blood cholesterol levels. Flavonoids may help inhibit the absorption of fat, which indirectly helps in lower cholesterol levels.Flavonoids are widely available on the Andrographis paniculata leaves (APL).This study aims to examine the effect of flavonoids in APL stewto lower the cholesterol levels. Material and Methods: This research was carried out using five different groups of Wistarrats. Each group consists of five Wistar rats. Group (K-) received normal diet, group (K+) received atherogenic diet and three groups of atherogenic diets rats that pre-treated with three different doses (0.6, 1.2, and 2.4g/day) of APL leaf stew. APL stew is orally gavaged for 60 days. The cholesterol blood serum was analyzed using the CHOD-PAP method. Statistical analysis using One-Way ANOVA and Post-Hoc Tukey. Results : The results showed a significant difference in cholesterol levels between the groups of theatherogenic diet with other treatment groups (p = 0.000).When compared with thenormal diet group, treatment with 1.2 g and 2.4 g of APL produce cholesterol levels not significantly different.APLstew has been shown to inhibit the elevated levels of serum cholesterol in male Wistar rats that fed with the atherogenic diet which contributed 54.8%.While fat intake increased the cholesterol level by 16.3%.Both APL stew and fat dose intake together affect the formation of cholesterol with a contribution of 69.2%. Conclusion : The dose that is considered as the most effective in lowering cholesterol is 2.4 g becauseit producescholesterol level closest to normal.

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“…Improving cellular cholesterol efflux by targeting macrophages is one approach. LXR agonism is one of the mechanisms that increases macrophage efflux capability [21].…”

Section: Enhancing the Ability To Excrete Cholesterolmentioning

confidence: 99%

The Antiatherogenic Effects of Flavonoid on Cholesterol Efflux Capacity

Ayoub¹

2022

Preprint

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One of the mechanisms used in the management and cure of atherosclerosis is reverse cholesterol transfer (RCT), which plays a vital role in the export of cholesterol from peripheral cells. Cholesterol efflux from macrophages in the subintima of the vessel wall is a critical part of RCT. ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1) are involved in the transfer of cholesterol from arterial macrophages to extracellular high-density lipoprotein cholesterol (HDL). The HDL then transports esterified cholesterol to the liver for elimination. An important factor in the reverse cholesterol transport and excretion of extracellular cholesterol is HDL. Atherogenesis can be prevented by altering the processes of RCT and cholesterol efflux, and this might lead to novel treatment options for cardiovascular disease. Research of novel modifying variables for RCT and cholesterol efflux is necessary. A better understanding of RCT's molecular processes has been gained via research, allowing for the creation of new treatments that make use of RCT's potential for pharmacological improvement. The purpose of this review is to provoke discussion on the potential impact of selected flavonoids on cholesterol efflux on the progression of atherosclerosis (Fig. 1.).

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Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

Cited by 59 publications

References 198 publications

Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats

Effect of Sambiloto (Andrographis paniculata) Leaves against Cholesterol Levels in Wistar Rats with Atherogenic Diet

The Antiatherogenic Effects of Flavonoid on Cholesterol Efflux Capacity

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