Therapeutic Effect of Folate-Targeted and PEGylated Phytosomes Loaded with a Mitomycin C–Soybean Phosphatidyhlcholine Complex

Li, Yang; Wu, Hongjie; Jia, Mengmeng; Cui, Fei; Lin, Jun; Yang, Xiangrui; Wang, Yange; Dai, Lingfeng; Hou, Zhenqing

doi:10.1021/mp5001873

Cited by 49 publications

(33 citation statements)

References 38 publications

(60 reference statements)

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“…The FA-PEG-MMC loaded phytosomes showed better cytotoxic effect and anticancer activity compared to the free MMC injection 34 . Silymarin phytosome show better antihepatotoxic activity than silymarin alone in broiler chicks that protect against the toxic effects of aflatoxin B1 42 .The mechanism behind improved cytotoxicity remains unstudied.…”

Section: In Vitro Cytotoxicity Assaymentioning

confidence: 91%

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Anti-Cancer Potency and Sustained Release of Phytosomal Diallyl Disulfide Containing Methanolic Allium Sativum Extract Against Breast Cancer

Nazeer¹,

Veeraiyan²,

Vijaykumar³

2017

Int. Res. J. Pharm.

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Vesicular drug delivery system like phytosomes is a widely adopted section of pharmaceutical inventions. It improves therapeu tic efficacies of drug by controlled and sustained action. It is also used to improve the therapeutic index, solubility, stability and rapid degradation of drug molecules. Phytosome is made of phytoconstituents of herbal extract that is surrounded and bounded by one or more concentric spheres of lipid layers. The purpose of this study is to synthesize an economical phytosome which will also be an effective alternative to the current medications of cancer. Methanolic extract of Allium sativum containing Diallyl disulphide along with other phenolic compounds were used for the preparation of phytosome as it has the ability to cure and prevent the growth and division of cancer cells. Bioactive compounds were examined by phytochemical analysis. Antioxidant activity of the extract was carried out by DPPH assay that showed that the extract was rich in antioxidants. Presence of Diallyl disulfide having the anti-cancer activity was confirmed by HPLC and GC-MS analysis. The surface morphology and the functional groups of the prepared phytosomal complex were studied by SEM and FTIR analysis respectively. The prepared phytosome showed 100% toxicity against the cancer cell line (MCF 7) at 108.5 μg/ml. Hence, we claim that the Diallyl disulphide containing methanolic Allium sativum encapsulated in phytosome can be an effective alternate for the cancer therapies and this work can also be extrapolated to active targeting of tumour site by attaching the targeting moiety on the surface of the phytosome.

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Section: In Vitro Cytotoxicity Assaymentioning

confidence: 91%

“…The polar heads on the phytosomic particles were observed in the Figure 4. At 30,000x magnification, the size of the phytosome was found to be 500nm.The size of mitomycin − soybean phosphatidyhlcholine complex loaded in phytosome was found to be 500nm 34 . …”

Section: Characterization Of Phytosome Sem Analysismentioning

confidence: 97%

Anti-Cancer Potency and Sustained Release of Phytosomal Diallyl Disulfide Containing Methanolic Allium Sativum Extract Against Breast Cancer

Nazeer¹,

Veeraiyan²,

Vijaykumar³

2017

Int. Res. J. Pharm.

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“…The outstanding properties of FA-PEG-MMC-loaded phytosomes comprise better cellular uptake in HeLa cells and developed accumulation in H22 tumour-bearing mice over that of the PEG-MMC-loaded phytosomes. Moreover, FA-PEG-MMC-loaded phytosomes were accompanied with superior cytotoxic activity in vitro and an enhanced antitumour effect in vivo compared to that resulting from free MMC injection 66 .…”

Section: Mitomycin Cmentioning

confidence: 95%

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

et al. 2017

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Nanotechnology offers a number of nanoscale implements for medicine. Among these, nanoparticles are revolutionizing the field of drug and gene delivery. Chitosan is a natural polymer which provides a profitable tool to an innovative delivery system due to its inherent physicochemical and biological characteristics. Chitosan nanoparticles are promising drug and gene delivery carriers because of small size, better stability, low toxicity, inexpensiveness, simplicity, easy fabrication and versatile means of administration. Chitosan can also be easily modified chemically due to the presence of reactive functional hydroxide and amine groups. Folic acid is commonly engaged as a ligand, for targeting cancer cells, as its receptor, that transports folic acid into the cells through endocytosis and is over-expressed on the surface of several human epithelial cancer cells. Integrating folic acid into chitosan-based drug delivery inventions directs the systems with a well-organized targeting ability. The present review outlines several illustrations of this versatile system based on folate decorated chitosan, which have shown potential as auspicious delivery systems published over the past few years. In addition, it is probable to formulate chitosan nanocarriers that exhibit manifold usage beyond targeted delivery, such as nanotheranostics and cancer stem cell therapy.

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“…For this purpose, mitomycin C loaded into soybean phosphatidylcholine phytosomes has been surface modified using folate-PEG so as to have targeted delivery and improved therapy in HeLa cells. The surface modified phytosomes have shown enhanced cellular uptake and better anticancer activity (Li et al 2014). …”

Section: Surface Modifications Of Liposomes and Phytosomesmentioning

confidence: 99%

Liposomal and Phytosomal Formulations

Guliani

Singla

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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Liposomes and phytosomes are kind of nanoparticles (NPs) which serve as an imperative tool for the delivery of various bioactive molecules. The molecules possessing lesser water solubility, bioavailability and retention time are encapsulated into both of these formulations. More specifically, liposomes can encapsulate both hydrophobic as well as hydrophilic molecules. While phytosomes contain only plant-based molecules having poor solubility in biological media like flavanones and terpenes. The various advantages of liposomes and phytosomes like biocompatibility, nontoxicity, ease to administer, decrease in dosage and increase in retention time make them potent vehicles for the drug delivery of various molecules. These nanoformulations find potential applications for delivery of various bioactive molecules, in tissue regeneration and as antimicrobials. This chapter highlights the importance of liposomes and phytosomes, methods of their preparation, mechanism of their action and applications.

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Therapeutic Effect of Folate-Targeted and PEGylated Phytosomes Loaded with a Mitomycin C–Soybean Phosphatidyhlcholine Complex

Cited by 49 publications

References 38 publications

Anti-Cancer Potency and Sustained Release of Phytosomal Diallyl Disulfide Containing Methanolic Allium Sativum Extract Against Breast Cancer

Anti-Cancer Potency and Sustained Release of Phytosomal Diallyl Disulfide Containing Methanolic Allium Sativum Extract Against Breast Cancer

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

Liposomal and Phytosomal Formulations

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