Therapeutic Approaches Towards the Treatment of Gastrointestinal
                        Disorders

Collingwood, S.P.; Witherington, Jason

doi:10.1358/dnp.2007.20.2.1113595

Cited by 3 publications

(2 citation statements)

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“…However, IBD management requires long-term treatments that often bring side effects, or may even lead to drug refractoriness or intolerance. Furthermore, these anti-inflammatory drugs do not prevent intestinal fibrosis, stricture formation, and consequent need for surgical intervention, especially in CD (44). These patients often respond inadequately to commonly used steroids, a condition that leads to a poor quality of life.…”

Section: Therapeutic Considerationsmentioning

confidence: 99%

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

Biasi

Leonarduzzi

Oteiza

et al. 2013

Antioxidants & Redox Signaling

223

145

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Oxidative stress is thought to play a key role in the development of intestinal damage in inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' aberrant immune and inflammatory responses to dietary antigens and to the commensal bacteria. During the active disease phase, activated leukocytes generate not only a wide spectrum of pro-inflammatory cytokines, but also excess oxidative reactions, which markedly alter the redox equilibrium within the gut mucosa, and maintain inflammation by inducing redoxsensitive signaling pathways and transcription factors. Moreover, several inflammatory molecules generate further oxidation products, leading to a self-sustaining and auto-amplifying vicious circle, which eventually impairs the gut barrier. The current treatment of IBD consists of long-term conventional anti-inflammatory therapy and often leads to drug refractoriness or intolerance, limiting patients' quality of life. Immune modulators or anti-tumor necrosis factor a antibodies have recently been used, but all carry the risk of significant side effects and a poor treatment response. Recent developments in molecular medicine point to the possibility of treating the oxidative stress associated with IBD, by designing a proper supplementation of specific lipids to induce local production of anti-inflammatory derivatives, as well as by developing biological therapies that target selective molecules (i.e., nuclear factor-jB, NADPH oxidase, prohibitins, or inflammasomes) involved in redox signaling. The clinical significance of oxidative stress in IBD is now becoming clear, and may soon lead to important new therapeutic options to lessen intestinal damage in this disease.

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Section: Therapeutic Considerationsmentioning

confidence: 99%

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

Biasi

Leonarduzzi

Oteiza

et al. 2013

Antioxidants & Redox Signaling

223

145

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“…FD has also increased national health care costs. Different therapeutic interventions have been applied to treat the disorder, but long-term satisfaction has not been achieved (3). the traditional medicine practices of different countries to treat the symptoms of FD.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Mentha longifolia in the Treatment of Patients With Postprandial Distress Syndrome: A Double-Blind, Randomized Clinical Trial

Babaeian

Naseri

Kamalinejad

et al. 2016

Iran Red Crescent Med J

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Background: Functional dyspepsia (FD) is a common gastrointestinal disease that has various treatments, including medicinal plants. Objectives: The current study aimed to investigate the effect of Mentha longifolia on relieving the symptoms and improving the quality of life (QOL) in patients with functional dyspepsia from the subgroup of postprandial distress syndrome (PDS). Patients and Methods: This randomized, double-blind, placebo-controlled trial was conducted in a gastroenterology clinic affiliated with Isfahan University of Medical Sciences. One hundred patients diagnosed with PDS according to the ROME III criteria were assigned to two groups: the M. longifolia capsules (three times daily for four weeks) group and the placebo group. Tools for gathering data were the FD severity scale and QOL (Persian version of the SF-36 questionnaire). Assessments of FD symptoms were obtained at baseline and also at the end of weeks 2, 4, and 12. QOL was evaluated at baseline and at the end of week 12. Results: At the end of treatment period, the M. longifolia group reported a more significant improvement in the mean severity scales of FD symptoms than the placebo group (P < 0.001). A significant difference was also observed between FD symptoms and severity scores in the two groups eight weeks after the medication was stopped. At the end of the fourth week, the greatest degrees of relief regarding epigastric bloating (70.5% vs. 21.4%, P < 0.001), epigastric fullness (68.2% vs. 31%, P < 0.001), loss of appetite (34.1% vs. 9.5%, P = 0.014) and early satiety (36.3% vs. 21.4%, P = 0.02) were observed in the control group. With M. longifolia, significant improvement in the scores of QOL was observed for the dimensions of general health, role-physical, social functioning, bodily pain, vitality, and mental health. Conclusions: This study showed the efficacy of M. longifolia in relieving PDS symptoms and improving the QOL of patients with PDS.

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Industrial-produced lemon nanovesicles ameliorate experimental colitis-associated damages in rats via the activation of anti-inflammatory and antioxidant responses and microbiota modification

Tinnirello,

Zizzo,

Conigliaro

et al. 2024

Biomedicine & Pharmacotherapy

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Therapeutic Approaches Towards the Treatment of Gastrointestinal Disorders

Cited by 3 publications

References 0 publications

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

The Efficacy of Mentha longifolia in the Treatment of Patients With Postprandial Distress Syndrome: A Double-Blind, Randomized Clinical Trial

Industrial-produced lemon nanovesicles ameliorate experimental colitis-associated damages in rats via the activation of anti-inflammatory and antioxidant responses and microbiota modification

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