Therapeutic applications of herbal/synthetic/bio-drug in oral cancer: An update

Mosaddad, Seyed Ali; Beigi, Kimia; Doroodizadeh, Tayebeh; Haghnegahdar, Maral; Golfeshan, Farzaneh; Ranjbar, Reza; Tebyanian, Hamid

doi:10.1016/j.ejphar.2020.173657

Cited by 45 publications

(29 citation statements)

References 178 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of undesired adverse effects linked to the use of conventional therapeutic techniques such as surgery, chemotherapy, radiotherapy, and immunotherapy, and even recently designated drug therapies mediated against specific cancer targets have compelled researchers to explore alternative treatment approaches. Previous reports have suggested that several dietary compounds such as saffron, ginger, and garlic exhibit promising anticancer and chemo-preventive effects without causing side effects accompanied with the use of synthetic drugs (Mosaddad et al, 2021). Various anticancer properties of saffron and its key ingredients are summarised in Table 1.…”

Section: Activities Against Cancersmentioning

confidence: 99%

Therapeutic potential of saffron, and its chemical components in the treatment of cancers and cardiovascular disorders – a review

Khan¹,

Muhamad²,

Taha³

et al. 2021

IFRJ

View full text Add to dashboard Cite

Crocus sativus L., a medicinally important species of the Iridaceae family which produces the herb saffron, plays an effective role in combating various pathogenic disorders including cancers and cardiovascular diseases. Apart from its conventional colorant and aroma-inducing attributes, various phytochemical compounds associated with saffron are now being intensively studied. More than 300 phytochemical compounds, derived from saffron stigmas alone, belong to various classes of secondary metabolites such as carotenoids, terpenoids, flavonoids, and anthocyanins; and they have immense therapeutic applications. Furthermore, pharmacogenomic studies of saffron extracts have revealed promising biocompatible and anticancer potentials against various drug-resistant cell lines which reduce cellular division and proliferation of malignant cells. Keeping in view with the numerous pharmacological properties associated with saffron, the present review explicitly discusses the role of its elemental contents in the prevention and treatment of various cancers and cardiovascular ailments.

show abstract

Section: Activities Against Cancersmentioning

confidence: 99%

Therapeutic potential of saffron, and its chemical components in the treatment of cancers and cardiovascular disorders – a review

Khan¹,

Muhamad²,

Taha³

et al. 2021

IFRJ

View full text Add to dashboard Cite

show abstract

“…Currently, the treatment strategy of oral cancer is mainly surgery, with or without radiotherapy, chemotherapy, targeted biological therapy, and immunotherapy as adjuvant therapy. However, early diagnosis, adverse effects, recurrence, and metastasis are still difficult problems in clinical treatment 3–5 . Thus, pursuing effective treatments is in urgent need.…”

Section: Introductionmentioning

confidence: 99%

Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1

Lou

Hou

et al. 2022

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background: We aimed to demonstrate the effects circ_0058063 exerted on oral squamous cell carcinoma (OSCC) and its downstream mechanism associated with miR-145-5p and SERPINE1. Methods:The relevant contents of miR-145-5p, circ 0058063, and SERPINE1 mRNAs in OSCC were evaluated using quantitative reverse transcription polymerase chain reaction. Functional experiments including CCK-8, Transwell, Western blot, and in vivo experiment were implemented to investigate the biological impacts on OSCC cells. Using dual-luciferase reporter, RIP, and RNA pull-down assays, the direct binding relationship between miR-145-5p, circ 0058063, and SERPINE1, SMAD3, CYR61, and IGF1R mRNAs was verified.Results: In OSCC, Circ 0058063 was significantly overexpressed. Knockdown of circ_0058063 suppressed OSCC cell migration and proliferation, but enhanced cell apoptosis. Functionally and mechanistically, circ_0058063 could specifically bind with miR-145-5p and thus upregulated expression of downstream target SERPINE1, which together contributed to the progression of OSCC. Conclusion:Circ_0058063 could promote the malignant behavior of OSCC by upregulating SERPINE1 through sponging miR-145-5p.

show abstract

“…Even though silver and gold have been extensively studied, the studies have been limited due to their high prices. e United States Environmental Protection Agency classi es copper (Cu) as an antimicrobial substance, abundant and relatively inexpensive, compared to other noble metals [1,4,[8][9][10][11]. Copper has recently gained popularity due to the COVID-19 pandemic, which reports that SARS-CoV-2 can decompose faster on copper surfaces than on plastic surfaces (4 hours).…”

Section: Introductionmentioning

confidence: 99%

Green Synthesize and Characterization of Copper Nanoparticles Using Iranian Propolis Extracts

Hajizadeh

Harzandi

Babapour

et al. 2022

Advances in Materials Science and Engineering

Self Cite

View full text Add to dashboard Cite

The propolis produced by bees is used by them to protect their hives. The cavity inside the hive’s walls is filled in during cold days to reduce entry points and mummify any intruders to ensure their survival. A current focus in nanotechnology and nanoscience is the green biosynthesis of nanoparticles (NPs) using biomaterials. Research on green methods for making metal oxide NPs is gaining momentum to safeguard the environment from the potential dangers associated with toxic chemicals. This study aimed to synthesize copper NPs (CuNPs) via propolis extraction, a novel application of nanoscience. The study was conducted under a range of pH, time conditions, and concentration ratios, and its properties were characterized by UV-Vis absorption spectra, XRD, and FTIR. An FTIR analysis revealed that compounds found in propolis extract could have an effect on the surface modification of the synthesized NPs. The propolis (Khalkhal) extract spectrum exhibited a sharp peak at 3422 cm−1, caused by free hydroxyl groups and their intra/intermolecular hydrogen bonds. There were sharp peaks at 2925, 1637, and 1515 to 1076 cm−1 associated with the C = O and C = C aromatic stretching frequencies. According to UV-Vis spectrophotometry investigation, CuO NPs exhibit a characteristic peak at 385 nm, showing significant surface plasmon resonance (SPR) with propolis (Khalkhal) extract. Furthermore, specific wavelengths of CuO NPs demonstrate peaks at 243, 292, and 350 nm for propolis (Gilan) extract. The green synthesis of CuNPs from Gilan and Khalkhal propolis can be an appropriate candidate for clinical applications such as drug delivery systems, drug formulation, and biomedical applications.

show abstract

Therapeutic applications of herbal/synthetic/bio-drug in oral cancer: An update

Cited by 45 publications

References 178 publications

Therapeutic potential of saffron, and its chemical components in the treatment of cancers and cardiovascular disorders – a review

Therapeutic potential of saffron, and its chemical components in the treatment of cancers and cardiovascular disorders – a review

Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR‐145‐5p and upregulating SERPINE1

Green Synthesize and Characterization of Copper Nanoparticles Using Iranian Propolis Extracts

Contact Info

Product

Resources

About