Therapeutic and Transmission-Blocking  Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against <i>Plasmodium vivax</i> Malaria, Cambodia

Popovici, Jean; Vantaux, Amélie; Primault, Lyse; Samreth, Reingsey; Piv, Eak Por; Bin, Sophalai; Kim, Saorin; Lek, Dysoley; Serre, David; Ménard, Didier

doi:10.3201/eid2408.170768

Cited by 11 publications

(5 citation statements)

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“…Amodiaquine, piperaquine, pyronaridine, and lumefantrine are recommended by WHO as partner drugs for artemisinin derivatives. Some common drug combinations include dihydroartemisinin-piperaquine (DHA-PPQ) [17] , artesunate-amodiaquine (AS-AQ) [18] , pyronaridine-artesunate (PY-AS) [19] , and artemether-lumefantrine (AL) [20] .…”

Section: Chloroquine As An Antimalarial Agentmentioning

confidence: 99%

Chloroquine against malaria, cancers and viral diseases

Zhou

Wang

Yang

et al. 2020

Drug Discovery Today

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Section: Chloroquine As An Antimalarial Agentmentioning

confidence: 99%

Chloroquine against malaria, cancers and viral diseases

Zhou

Wang

Yang

et al. 2020

Drug Discovery Today

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“…Artemisinin compounds have already been described as faster in clearing asexual P . vivax parasites and blocking human-to-mosquito transmission when compared with chloroquine [ 16 , 34 – 37 ]. Artemisinin-based combination therapy (ACT) has been adopted in areas where the efficacy of chloroquine is decreasing.…”

Section: Discussionmentioning

confidence: 99%

Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi

et al. 2023

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Malaria is caused by parasite of the genus Plasmodium and is still one of the most important infectious diseases in the world. Several biological characteristics of P. vivax contribute to the resilience of this species, including early gametocyte production, both of which lead to efficient malaria transmission to mosquitoes. This study evaluated the impact of currently used drugs on the transmission of P. vivax. Participants received one of the following treatments for malaria: i) chloroquine [10 mg/kg on day 1 and 7.5 mg/kg on day 2 and 3] co-administered with Primaquine [0.5 mg/kg/day for 7 days]; ii) Chloroquine [10 mg/kg on day 1 and 7.5 mg/kg on day 2 and 3] co-administered with one-dose of Tafenoquine [300 mg on day 1]; and iii) Artesunate and Mefloquine [100 mg and 200 mg on day 1, 2 and 3] co-administered with Primaquine [0.5 mg/kg/day for 14 days]. Patient blood was collected before treatment and 4 h, 24 h, 48 h and 72 h after treatment. The blood was used to perform a direct membrane feeding assay (DMFA) using Anopheles darlingi mosquitoes. The results showed 100% inhibition of the mosquito infection after 4 h using ASMQ+PQ, after 24 h for the combination of CQ+PQ and 48 h using CQ+TQ. The density of gametocytes declined over time in all treatment groups, although the decline was more rapid in the ASMQ+PQ group. In conclusion, it was possible to demonstrate the transmission-blocking efficacy of the malaria vivax treatment and that ASMQ+PQ acts faster than the two other treatments.

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“…Dihydroartemisinin (DHA), a derivative of artemisinin isolated from Artemisia annua , exhibits a potent antimalarial efficacy with low recurrence and is often prepared into granules [ 54 ]. However, the bitter taste of DHA always results in low patient compliance, especially for pediatric patients, and thus reduces its curative efficacy in the clinic [ 39 ].…”

Section: Physical Maskingmentioning

confidence: 99%

Developments in Taste-Masking Techniques for Traditional Chinese Medicines

Zheng

Yang

et al. 2018

Pharmaceutics

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A variety of pharmacologically active substances, including chemotherapeutic drugs and the substances from traditional Chinese medicine (TCM), always exhibit potent bioactivities after oral administration. However, their unpleasant taste (such as bitterness) and/or odor always decrease patient compliance and thus compromise their curative efficacies in clinical application. Therefore, the developments of taste-masking techniques are of great significance in improving their organoleptic properties. However, though a variety of taste-masking techniques have been successfully used to mask the unpalatable taste of chemotherapeutic drugs, their suitability for TCM substances is relatively limited. This is mainly due to the fact that the bitter ingredients existing in multicomponent TCM systems (i.e., effective fractions, single Chinese herbs, and compound preparations) are always unclear, and thus, there is lack of tailor-made taste-masking techniques to be utilized to conceal their unpleasant taste. The relevant studies are also relatively limited. As a whole, three types of taste-masking techniques are generally applied to TCM, including (i) functional masking via sweeteners, bitter blockers, and taste modifiers; (ii) physical masking via polymer film-coating or lipid barrier systems; and (iii) biochemical masking via intermolecular interaction, β-cyclodextrin inclusion, or ion-exchange resins. This review fully summarizes the results reported in this field with the purpose of providing an informative reference for relevant readers.

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Therapeutic and Transmission-Blocking  Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

Cited by 11 publications

References 11 publications

Chloroquine against malaria, cancers and viral diseases

Chloroquine against malaria, cancers and viral diseases

Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi

Developments in Taste-Masking Techniques for Traditional Chinese Medicines

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Therapeutic and Transmission-Blocking Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia

Cited by 11 publications

References 11 publications

Chloroquine against malaria, cancers and viral diseases

Chloroquine against malaria, cancers and viral diseases

Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi

Developments in Taste-Masking Techniques for Traditional Chinese Medicines

Contact Info

Product

Resources

About

Therapeutic and Transmission-Blocking  Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia