Developments in Taste-Masking Techniques for Traditional Chinese Medicines

Zheng, Xiao; Wu, Fei; Yang, Hong; Shen, Lan; Lin, Xiao; Feng, Yi

doi:10.3390/pharmaceutics10030157

Cited by 48 publications

(31 citation statements)

References 81 publications

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“…As the oral administration is the most accepted route, masking the unpleasant taste of drugs to an acceptable degree of palatability is important during formulation. Masking techniques can be integrated into three levels: 1) formulation level, through sweeteners and flavors; 2) particle level, by creating a physical barrier between the bitter component and the taste receptors; and 3) molecular level, through the complexation of the drug with CDs or ion-exchange resins [ 48 , 49 ].…”

Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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We herein disclose how global cyclodextrin-based pharmaceutical technologies have evolved since the early 80s through a 1998 patents dataset retrieved from Derwent Innovation Index. We used text-mining techniques based on the patents semantic content to extract the knowledge contained therein, to analyze technologies related to the principal attributes of CDs: solubility, stability, and taste-masking enhancement. The majority of CDs pharmaceutical technologies are directed toward parenteral aqueous solutions. The development of oral and ocular formulations is rapidly growing, while technologies for nasal and pulmonary routes are emerging and seem to be promising. Formulations for topical, transdermal, vaginal, and rectal routes do not account for a high number of patents, but they may be hiding a great potential, representing opportunity research areas. Certainly, the progress in materials sciences, supramolecular chemistry, and nanotechnology, will influence the trend of that, apparently neglected, research. The bottom line, CDs pharmaceutical technologies are still increasing, and this trend is expected to continue in the coming years. Patent monitoring allows the identification of relevant technologies and trends to prioritize research, development, and investment in both, academia and industry. We expect the scope of this approach to be applied in the pharmaceutical field beyond CDs technological applications.

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Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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“…More importantly, VOC was brownish yellow oil and had extremely pungent smell, while VOC-β-CD had almost no pungent smell for people in our lab. Literatures showed that the inclusion complex not only effectively enhanced the dissolution of drugs in aqueous solutions, but also showed the potential to mask its bitter taste in the oral cavity [ 4 , 29 , 30 , 42 , 48 ]. VOC-P188 had a faint yellow appearance and still had pungent smell.…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound

Zhong

Jiao

et al. 2021

BMC Complement Med Ther

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Backgrounds The dried rhizome of Ligusticum sinense Oliv.cv. Chaxiong has been used to treat cardiovascular and cerebrovascular diseases, atherosclerosis, anemia and stroke. A high purity extract from chaxiong (VOC, brownish yellow oil) was extracted and separated. Its main components were senkyunolide A (SA, 33.81%), N-butylphthalide (NBP, 1.38%), Neocnidilide (NOL, 16.53%), Z-ligustilide (ZL, 38.36%), and butenyl phthalide (BP, 2.48%), respectively. Little is known about the pharmacokinetics of these phthalides in Chaxiong, and different preparations to improve the physicochemistry and pharmacokinetics of VOC have not been investigated. Methods At different predetermined time points after oral administration or intravenous administration, the concentrations of SA, NBP, NOL, ZL and BP in the rat plasma were determined using LC-MS/MS, and the main PK parameters were investigated. VOC-P188 solid dispersion and VOC-β-CD inclusion compound were prepared by melting solvent method and grinding method, respectively. Moreover, the physicochemical properties, dissolution and pharmacokinetics of VOC-P188 solid dispersion and VOC-β-CD inclusion compound in rats were assessed in comparison to VOC. Results The absorptions of SA, NBP, NOL, ZL and BP in VOC were rapid after oral administration, and the absolute bioavailability was less than 25%. After the two preparations were prepared, dissolution rate was improved at pH 5.8 phosphate buffer solution. Comparing VOC and physical mixture with the solid dispersion and inclusion compound, it was observed differences occurred in the chemical composition, thermal stability, and morphology. Both VOC-P188 solid dispersion and VOC-β-CD inclusion compound had a significantly higher AUC and longer MRT in comparison with VOC. Conclusion SA, NBP, NOL, ZL and BP in VOC from chaxiong possessed poor absolute oral bioavailability. Both VOC-P188 solid dispersion and VOC-β-CD inclusion compound could be prospective means for improving oral bioavailability of SA, NBP, NOL, ZL and BP in VOC.

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“…Sucrose and maltodextrin in granules have two functions: sweeteners and fillers. [20][21][22][23][24] Based on the organoleptic test results, it can be concluded that the processed functional beverage granules complied with the predetermined specifications. The functional beverage granules prepared from the combined extracts of guava © 2021 the authors.…”

Section: Resultsmentioning

confidence: 99%

Formulation and Evaluation of Two Types of Functional Beverage Granules Made of Extracts of Guava Leaves, Purple Sweet Potato and Cinnamon

2021

TJNPR

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Psidium guajava L., commonly known as guava, is a shrub that belongs to the Myrtaceae family and is native to Southern Mexico, Central America, and South America. The plant is widely cultivated in almost all parts of the world because it grows easily in tropical and subtropical climates. In several countries, guava leaves are traditionally used for, especially, anti-diarrhea. In another dosage form, i.e., infusion or decoction, the leaves prove effective in the treatment of rheumatism, diarrhea, diabetes mellitus, and cough in India, China, Pakistan, and Bangladesh. In South Asia and Nigeria, a guava leaf decoction is used for mouthwash and anti-bacterial agent. Some external uses of the plant include topical application on injured skin, as widely practiced in Mexico, Brazil, the Philippines, and Nigeria. Also, in Ethnomedicine, the leaves are used by the people of the Muna tribe in Southeast Sulawesi as anti-diarrhea medicines. 1,2 Guava leaves have active compounds, such as polyphenols, ascorbate, gallic acid, caffeine, flavonoids (quercetin), tannins, and isoprenoids. These are associated with several pharmacological activities, namely cough suppressant, anti-spasmolytic, anti-bacterial, anti-amoebic, antifungal, anti-diarrhea, anti-hyperglycemia, antioxidants, cardioprotective effects, and immunostimulants. 3,4

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Developments in Taste-Masking Techniques for Traditional Chinese Medicines

Cited by 48 publications

References 81 publications

Technological evolution of cyclodextrins in the pharmaceutical field

Technological evolution of cyclodextrins in the pharmaceutical field

Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound

Formulation and Evaluation of Two Types of Functional Beverage Granules Made of Extracts of Guava Leaves, Purple Sweet Potato and Cinnamon

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