Theranostic nanomotors for tumor multimode imaging and photothermal/photodynamic synergistic therapy

Liu, Huaxiao; Zhang, Jinzha; Jia, Yaning; Li, Xuan; Chen, Xiaoqiang; Zhao, Wenbo; Mao, Chun

doi:10.1016/j.cej.2022.135994

Cited by 23 publications

(12 citation statements)

References 62 publications

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“…In terms of PTT/PDT combined diagnosis and treatment, Mao et al reported a theranostic nanomotor fabricated by in situ formation of Au NPs on UCNPs@ mSiO 2 core-shell nanoparticle and then loaded with PS (Figure 8D). [131] The asymmetrically distributed photothermal agent, AuNPs, not only provided driving force for motility, but also acted as a heat resource for PTT and NIR photothermal imaging. Furthermore, AuNPs could enhance the efficiency of O 2 -dependent PDT by decomposing H 2 O 2 .…”

Section: Pdtmentioning

confidence: 99%

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Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Liu

et al. 2023

Adv Funct Materials

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Untethered mobile micro-/nanomotors (MNMs), as newly-emerging attractive and versatile nanotechnologies, are expected to be the next-generation disease treatment tools, for breaking through the limitations of conventional passive drug delivery manner. However, the advances in these fascinating platforms have been hampered by the complexity of the biological environment and the particularity of disease microenvironment. Consequently, specific design strategies and clinical imaging techniques are essential to ensure the high-efficiency of biomedical MNMs on actuation, targeting, localization, and therapy when performing assigned in vivo tasks. This review thus comprehensively addresses three aspects of biomedical MNMs, including design, imaging, and disease treatment, highlighting the intelligent MNMs with biomimetic functionality and chemotactic capability, emphasizing the applicability of different imaging techniques, and focusing on various proofof-concept studies based on physiological characteristics for the treatment of major diseases. In addition, the key challenges and limitations of current biomedical MNMs are addressed, which may inspire future research and facilitate translation toward clinical treatment.

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Section: Pdtmentioning

confidence: 99%

Section: Pdtmentioning

confidence: 99%

Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Liu

et al. 2023

Adv Funct Materials

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“…Compared with the conventional strategy of passively targeting nanoparticles, micro/nanomotors with Janus nanostructures can show better therapeutic effects. [48][49][50][51][52][53][54][55] Based on this, we constructed multifunctional matchstick Au@ZnO@SiO 2 -ICG Janus nanomotors to realize the synergistic killing of bacteria by the combination of PTT/PDT. Firstly, matchstick Au@ZnO Janus nanoparticles were prepared by Au seed mediated nucleation and ZnO growth, then coated with a SiO 2 thin layer on the ZnO part, [56][57][58] and loaded with the photosensitizer ICG to obtain matchstick-like Au@ZnO@SiO 2 -ICG nanomotors (Scheme 1a).…”

Section: Introductionmentioning

confidence: 99%

“…Compared with the conventional strategy of passively targeting nanoparticles, micro/nanomotors with Janus nanostructures can show better therapeutic effects. 48–55…”

Section: Introductionmentioning

confidence: 99%

Construction of a matchstick-shaped Au@ZnO@SiO₂–ICG Janus nanomotor for light-triggered synergistic antibacterial therapy

Liu

Zhang

et al. 2022

Biomater. Sci.

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“…Photothermal effect is a phenomenon associated with material absorption of electromagnetic waves, resulting in the production of thermal energy (heat). This effect has been utilized for effective cancer treatment, i.e., photothermal therapy (PTT), by localized non-invasive therapeutic interventions through tumor-seated photothermal agents, which generate hyperthermia to kill tumor cells (via heating them to 42-45 °C or even higher) [40][41][42][43][44][45][46][47][48][49]. Indeed, marriage of PTT with nanozyme (using Fe 3 O 4 nanozyme and Pd nanosheet complexes, and platinum nanozymes coated with porous gold nanoshell) was observed to yield an enhanced tumor theranostics through visible or near infrared light in the first biological window (NIR-I, 650-950 nm) [50][51][52][53][54].…”

Section: Introductionmentioning

confidence: 99%

A bimodal type of AgPd Plasmonic Blackbody Nanozyme with boosted catalytic efficacy and synergized photothermal therapy for efficacious tumor treatment in the second biological window

Tao

et al. 2022

J Nanobiotechnol

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Nanozymes are promising for precise cancer treatment, but are typically limited in terms of the low catalytic efficiency and the complexity in tumor microenvironment (TME). Herein, we describe a bimodal type of AgPd plasmonic blackbody (AgPd PB) nanozyme of compact sizes (< 30 nm), which presents not only boosted enzyme efficacy but also efficient photothermal therapy (PTT) for synergized therapy through tissue-penetrating light in the second biological window (1000–1700 nm). The synthesized hyperbranched AgPd PB nanozymes possess intense and broadband localized surface plasmonic resonance absorption of 400–1300 nm, entailing prominent photothermal efficiency (η = 45.1% at 1064 nm) for PTT. Importantly, PTT was found to significantly boost the nanozyme efficacy of both catalase (CAT) and peroxidase (POD) processes, which correspondingly decompose H2O2 to into O2 to relieve tumor hypoxia, and activate H2O2 to generate oxidative •OH radical. While the generated •OH was found to be able to minimize heat shock proteins (HSPs), which plays a vital role to counterbalance PTT effect both in vitro and in vivo. As compared to control ground without treatment, the synergized nanozyme and PTT activities resulted in about 7-fold reduction of tumor volume, thus elevating the survival rate from 0 to 80% at 30 days posttreatment. Besides the synergistic therapy, the AgPd PB nanozyme were shown to own fluorescence, computed tomography (CT), and photoacoustic (PA) imaging abilities, thus having implications for uses in imaging-guided precise cancer therapy. This study provides a paradigm of TME responsive theranostics under NIR-II light irradiation. Graphical Abstract

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Theranostic nanomotors for tumor multimode imaging and photothermal/photodynamic synergistic therapy

Cited by 23 publications

References 62 publications

Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Construction of a matchstick-shaped Au@ZnO@SiO₂–ICG Janus nanomotor for light-triggered synergistic antibacterial therapy

A bimodal type of AgPd Plasmonic Blackbody Nanozyme with boosted catalytic efficacy and synergized photothermal therapy for efficacious tumor treatment in the second biological window

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Theranostic nanomotors for tumor multimode imaging and photothermal/photodynamic synergistic therapy

Cited by 23 publications

References 62 publications

Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Biomedical Micro‐/Nanomotors: Design, Imaging, and Disease Treatment

Construction of a matchstick-shaped Au@ZnO@SiO2–ICG Janus nanomotor for light-triggered synergistic antibacterial therapy

A bimodal type of AgPd Plasmonic Blackbody Nanozyme with boosted catalytic efficacy and synergized photothermal therapy for efficacious tumor treatment in the second biological window

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Construction of a matchstick-shaped Au@ZnO@SiO₂–ICG Janus nanomotor for light-triggered synergistic antibacterial therapy