Theory of polymer-entrapped enzyme ultramicroelectrodes: Application to glucose and adenosine triphosphate detection

Kottke, Peter A.; Kranz, Christine; Kwon, Yong Koo; Masson, Jean-François; Mizaikoff, Boris; Fedorov, Andrei G.

doi:10.1016/j.jelechem.2008.02.025

Cited by 3 publications

(1 citation statement)

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“…A pair of groups sought shorter measurement periods for biosensors,[273, 274] including real-time monitoring. [274] Mizaikoff and colleagues[270, 271] developed and tested a generalized theory for the preparation and optimization of dual enzyme biosensors so that future biosensors could be developed more rapidly. The dual enzyme design was also used to perform scanning electrochemical microscopy and image the transport of ATP through a porous membrane.…”

Section: Nucleosidesmentioning

confidence: 99%

Review of recent advances in analytical techniques for the determination of neurotransmitters

Perry

Kennedy

2009

Analytica Chimica Acta

331

221

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Methods and advances for monitoring neurotransmitters in vivo or for tissue analysis of neurotransmitters over the last five years are reviewed. The review is organized primarily by neurotransmitter type. Transmitter and related compounds may be monitored by either in vivo sampling coupled to analytical methods or implanted sensors. Sampling is primarily performed using microdialysis, but low-flow push-pull perfusion may offer advantages of spatial resolution while minimizing the tissue disruption associated with higher flow rates. Analytical techniques coupled to these sampling methods include liquid chromatography, capillary electrophoresis, enzyme assays, sensors, and mass spectrometry. Methods for the detection of amino acid, monoamine, neuropeptide, acetylcholine, nucleoside, and soluable gas neurotransmitters have been developed and improved upon. Advances in the speed and sensitivity of these methods have enabled improvements in temporal resolution and increased the number of compounds detectable. Similar advances have enabled improved detection at tissue samples, with a substantial emphasis on single cell and other small samples. Sensors provide excellent temporal and spatial resolution for in vivo monitoring. Advances in application to catecholamines, indoleamines, and amino acids have been prominent. Improvements in stability, sensitivity, and selectivity of the sensors have been of paramount interest.

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