Theoretical and Experimental Research on Multi-Layer Vessel-like Structure Printing Based on 3D Bio-Printing Technology

Liu, Huanbao; Yang, Xianhai; Cheng, Xiang; Guo, Zhao; Zheng, Guangming; Li, Xuewei; Dong, Ruichun

doi:10.3390/mi12121517

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…Layer-by-layer printing [ 30 ], without support, can print different shapes of blood vessels, but the resulting surface has poor quality and poor mechanical properties. Supported printing [ 24 ] can ensure the inner diameter of blood vessels. The printed blood vessels have a smooth surface and high molding quality, but the total size of the blood vessels cannot be guaranteed due to the influence of vessel wall thickness.…”

Section: Discussionmentioning

confidence: 99%

“…It provided a suitable hydrogel scaffold for cell proliferation, migration, and differentiation in tissue engineering. Liu H. et al [ 24 ] used sodium alginate and gelatin as experimental materials to fabricate multilayer vascular structures and analyzed cell loading materials, and the cell survival rate was more than 90%, which provided support for the research of printing multilayer vascular structures. Iranmanesh P. et al [ 25 ] prepared a novel alginate/gelatin scaffold with a drug-coated surface, which can improve mechanical and biological properties.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel

Jin

Liu

Nie

et al. 2022

IJMS

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Vascular replacement is one of the most effective tools to solve cardiovascular diseases, but due to the limitations of autologous transplantation, size mismatch, etc., the blood vessels for replacement are often in short supply. The emergence of artificial blood vessels with 3D bioprinting has been expected to solve this problem. Blood vessel prosthesis plays an important role in the field of cardiovascular medical materials. However, a small-diameter blood vessel prosthesis (diameter < 6 mm) is still unable to achieve wide clinical application. In this paper, a response surface analysis was firstly utilized to obtain the relationship between the contact angle and the gelatin/sodium alginate mixed hydrogel solution at different temperatures and mass percentages. Then, the self-developed 3D bioprinter was used to obtain the optimal printing spacing under different conditions through row spacing, printing, and verifying the relationship between the contact angle and the printing thickness. Finally, the relationship between the blood vessel wall thickness and the contact angle was obtained by biofabrication with 3D bioprinting, which can also confirm the controllability of the vascular membrane thickness molding. It lays a foundation for the following study of the small caliber blood vessel printing molding experiment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel

Jin

Liu

Nie

et al. 2022

IJMS

Self Cite

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“…As the complexity of the design increases, introducing multiple material printing nozzles into the performance amplifies the intricacy of the choreography . The synchronization of multiple nozzles to realize multimaterial or multicellular designs though demands rigorous calibration and harmonization .…”

Section: Practical Challenges In Bioprinting Complex Designsmentioning

confidence: 99%

“…As the complexity of the design increases, introducing multiple material printing nozzles into the performance amplifies the intricacy of the choreography. 39 The synchronization of multiple nozzles to realize multimaterial or multicellular designs though demands rigorous calibration and harmonization. 40 This multifaceted challenge arises due to the interplay of various factors, including nozzle dynamics, deposition rates, and material rheology.…”

Section: Practical Challenges In Bioprinting Complex Designsmentioning

confidence: 99%

Prioritizing Biomaterial Driven Clinical Bioactivity Over Designing Intricacy during Bioprinting of Trabecular Microarchitecture: A Clinician’s Perspective

Kumar Shetty,

Sundar Santhanakrishnan,

Padurao

et al. 2024

ACS Omega

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Bone tissue engineering has witnessed a historical shift from three perspectives. From a biomaterial perspective, materials have now become smarter and dynamic; from a bioengineering perspective the bioprinting techniques have now advanced to 4D bioprinting; and from a clinical perspective scaffold bioactivity has progressed toward enhanced osteoinductive scaffolds driven by intricate biomechanical, biophysical, biochemical, and biological cues. Though all of these advancements are indicative of improvised scaffold engineering, a pivotal question regarding the critical role and need of designing and replicating the intricacies of trabecular microarchitecture for enhanced, clinically appreciable osteoangiogenicity needs to be answered. This review hence critically evaluates the rationale and the need of investing substantial effort into designing complex microarchitectures amidst the era of "smart biomaterials" and dynamic 4D bioprinting aimed toward enhancing clinically appreciable bioactivity. The article explores the concept of integrating intricate designs into a scaffold microarchitecture to bolster bioactivity and the practical challenges encountered in 3D bioprinting of complex designs and meticulously examines the pivotal role of biomaterials in scaffold bioactivity, proposing a comprehensive approach to bioprinting geared toward achieving clinical bioactivity and striking a judicious balance between design intricacy and functional outcomes in bone bioprinting.

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“…As microfluidic chips become significant equipment in our daily lives, such as in office printing, 3D printing, cell bioprinting, and food printing, the sizes and structures of inkjet chips are constantly being upgraded [ 1 , 2 ]. In sensor manufacturing, screen printing [ 3 ] and inkjet printing [ 4 , 5 ] have a high penetration rate.…”

Section: Introductionmentioning

confidence: 99%

Design of Chopsticks-Shaped Heating Resistors for a Thermal Inkjet: Based on TaN Film

Peng

Sun³

et al. 2022

Micromachines

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Efficient printing frequency is critical for thermal bubble inkjet printing, while the difficulty lies in the structural design and material selection of the heating resistors. In this paper, a TaN film was used as the main material of the heating resistors, and two TaN films were placed in parallel to form the chopsticks-shaped structure. The heating time was divided into two sections, in which 0–0.1 μs was the preheating and 1.2–1.8 μs was the primary heating. At 1.8 μs, the maximum temperature of the Si3N4 film could reach about 1100 °C. At the same time, the SiO2 film was added between the TaN film and Si3N4 film as a buffer layer, which effectively avoided the rupture of the Si3N4 film due to excessive thermal stress. Inside the inkjet print head, the maximum temperature of the chamber reached about 680 °C at 2.5 μs. Due to the high power of the heating resistors, the working time was greatly reduced and the frequency of the inkjet printing was effectively increased. At the interface between the back of the chip and the cartridge, the SiO2 film was used to connect to ensure a timely ink supply. Under the condition of 12 V at 40 kHz, the inkjet chip could print efficiently with 10 nozzles at the same time. The inkjet chip proposed in this paper is not limited to only office printing, but also provides a new reference for 3D printing, cell printing, and vegetable and fruit printing.

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Theoretical and Experimental Research on Multi-Layer Vessel-like Structure Printing Based on 3D Bio-Printing Technology

Cited by 9 publications

References 20 publications

Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel

Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel

Prioritizing Biomaterial Driven Clinical Bioactivity Over Designing Intricacy during Bioprinting of Trabecular Microarchitecture: A Clinician’s Perspective

Design of Chopsticks-Shaped Heating Resistors for a Thermal Inkjet: Based on TaN Film

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