Cardiovascular disease is the leading cause of death worldwide. Traditional autologous transplantation has become a severe issue due to insufficient donors. Artificial blood vessel is an effective method for the treatment of major vascular diseases, such as heart and peripheral blood vessel diseases. However, the traditional single-material printing technology has been unable to meet the users’ demand for product functional complexity, which is not only reflected in the field of industrial manufacturing, but also in the field of functional vessel-like structure regeneration. In order to achieve the printing and forming of multi-layer vessel-like structures, this paper carries out theoretical and experimental research on the printing and forming of a multi-layer vessel-like structure based on multi-material 3D bioprinting technology. Firstly, theoretical analysis has been explored to research the relationship among the different parameters in the process of vessel forming, and further confirm the synchronous relationship among the extrusion rate of material, the tangential speed of the rotating rod, and the movement speed of the platform. Secondly, sodium alginate and gelatin have been used as the experimental materials to manufacture the vessel-like structure, and the corrected parameter of the theoretical analysis is further verified. Finally, the cell-loaded materials have been printed and analyzed, and cell viability is more than 90%, which provides support for the research of multi-layer vessel-like structure printing.
Polyetheretherketone (PEEK) material has attracted attentions and studies in the medical field due to its excellent properties suitable for orthopedic, dental, and implant applications. In order to acquire the needed geometrical accuracy and surface finish for individual customizations of components made of PEEK material, milling process basics for PEEK material have been studied in this paper. The influences of milling parameters on milling forces and surface roughness are discussed based on single-factor and orthogonal milling experiments. It shows that the effects of cutting parameters on cutting forces are basically in accordance with that in the classical metal cutting theory. But the effects of cutting parameters on the surface roughness are different. Also the significance sequences of the key milling parameters on milling forces and surface roughness are identified. Furthermore, a finite element simulation model to estimate the milling force is established and successfully evaluated for customized applications.
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