Vascular replacement is one of the most effective tools to solve cardiovascular diseases, but due to the limitations of autologous transplantation, size mismatch, etc., the blood vessels for replacement are often in short supply. The emergence of artificial blood vessels with 3D bioprinting has been expected to solve this problem. Blood vessel prosthesis plays an important role in the field of cardiovascular medical materials. However, a small-diameter blood vessel prosthesis (diameter < 6 mm) is still unable to achieve wide clinical application. In this paper, a response surface analysis was firstly utilized to obtain the relationship between the contact angle and the gelatin/sodium alginate mixed hydrogel solution at different temperatures and mass percentages. Then, the self-developed 3D bioprinter was used to obtain the optimal printing spacing under different conditions through row spacing, printing, and verifying the relationship between the contact angle and the printing thickness. Finally, the relationship between the blood vessel wall thickness and the contact angle was obtained by biofabrication with 3D bioprinting, which can also confirm the controllability of the vascular membrane thickness molding. It lays a foundation for the following study of the small caliber blood vessel printing molding experiment.
Three-dimensional printing concrete is a digital and automating construction technology, which is expected to solve a series of problems existing in the traditional construction industry, such as low automation, high labor intensity, low efficiency and high risk. However, there are still many technical and operational challenges. The purpose of this paper is to provide insights into the effects of process parameters on the geometry and stability of the printed layer. Firstly, a theoretical model is established to analyze the structure of the printed layer under different nozzle speeds, material flow rates and nozzle offset. Secondly, a slump test is carried out to select the optimal ratio suitable for 3D cement printers, and the specimen is printed under various conditions. Finally, based on the obtained parameters, multiple nozzles are used for printing, and a pressure value suitable for each nozzle in the nonlinear path is calculated. The experimental results show that theoretical model can sufficiently verify printing structure in different parameter intervals, and the process parameters (nozzle speed, material flow rate and nozzle offset) can be changed to achieve the best effect of cement-based material forming structure.
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