Theophylline-associated status epilepticus in an infant: pharmacokinetics and the risk of suppository use

Kato, Zenichiro; Yamagishi, Atsushi; Nakamura, Mitsuhiro; Kondo, Naomi

doi:10.1007/s12519-009-0061-y

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…In one series of 114 children presenting to a single center with SE over 2 years [49], 16 were taking theophylline, with 8 having clear toxicity associated with a worse outcome. Misuse of suppositories in particular seems to be associated with a higher risk of toxicity with sometimes catastrophic outcomes [50].…”

Section: Othersmentioning

confidence: 99%

Drug-induced status epilepticus

Cock

2015

Epilepsy & Behavior

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Section: Othersmentioning

confidence: 99%

Drug-induced status epilepticus

Cock

2015

Epilepsy & Behavior

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“…While theophylline is used as an adjunctive therapeutic agent to treat bovine respiratory disease, there may be risks associated with typhoid [25,26]. Some authors [16,[27][28][29] reported that symptoms such as tachycardia, tachycardia, vomiting, diarrhea, reflux and muscle spasms could be formed. In our study, significant increases in respiratory and cardiac frequencies in DG animals following the application of theophylline (Table 1) were consistent with those reported by these investigators.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the probable cause of high baseline TB and DB levels was due to maternal erythrocyte destruction, the decreasing levels were not related to theophylline, but the difference between TB and DB concentrations in BSE and BSE animals. Kato et al [28] report that low and short-term use of theophylline may lead to an increase in blood enzyme levels of theophylline, which does not lead to a significant increase but reaches high plasma concentrations and / or is used for a long time.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

JOJCS

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The aim of this study was to demonstrate the therapeutic efficacy of theophylline, a respiratory stimulant and bronchodilator, which was commonly used in the human medicine and less frequently used in the veterinary field, in respiratory system diseases. Materials and Methods Animal materialsThe study was carried out in a total of 50 calves, 25 control groups (KG) and 25 experimental groups (DG), 0 to 6 months old, who were found to have developed a respiratory system problem clinically in Uşak city and according to the method

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“…Thus, therapies with a favorable benefit to harm ratio in efficacy studies may offer no net benefit in some groups of patients in real-world clinical practice settings; in other words, therapies with demonstrated efficacy may not be effective in some patient subgroups. In some cases, efficacious treatments may even result in net harm in some patients when applied more broadly in routine practice, as was shown in the large post-marketing clinical trial of salmeterol in patients with asthma and in case reports related to other asthma therapies 13,14. Moreover, use of inactive controls in randomized clinical trials (e.g., placebo or sham), may not provide the information needed by patients and clinicians when considering existing (including non-medication) treatment alternatives.…”

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confidence: 99%

A call for action: Comparative effectiveness research in asthma

Krishnan¹,

Schatz²,

Apter³

2011

Journal of Allergy and Clinical Immunology

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Comparative effectiveness research (CER) has received considerable research attention in recent months, and efforts to promote CER are part of the newly enacted Patient Protection and Affordable Care Act. In this paper, we define CER, how it complements traditional efficacy research in asthma, and discuss how CER can help provide the basis for rational decision-making about the care of individual patients with asthma and how best to deliver this care in real-world settings. We present information about the challenges and opportunities to conduct CER, including enhanced patient registries for observational CER and effectiveness trials (also called pragmatic trials). We discuss the urgent need to define the appropriate methodologies for CER and to develop and prioritize a research agenda for CER studies in asthma with the help of a diverse group of stakeholders. KeywordsComparative effectiveness research; comparative clinical effectiveness research; observational studies; effectiveness trials; efficacy trials; pragmatic trials; explanatory trials; asthma Randomized controlled trials are the gold standard by which the benefits and harms of treatments have been established, because this approach greatly minimizes the risk of confounding and avoids selection bias. Such studies have traditionally employed an efficacy paradigm in which various approaches are used to amplify the signal-to-noise ratio in order to address the question "Can this intervention work?" Such studies are critical to the development of innovative approaches to patient care. A hallmark of the efficacy trials is the application of narrowly defined inclusion and exclusion criteria to select study subjects. A recent study found, for example, that a median of 6% (range 0 to 43%) of patients treated for asthma met eligibility criteria for major trials cited in evidence-based treatment guidelines. 1 A high level of selectiveness is employed in efficacy trials to ensure that study subjects are enriched with patients most likely to benefit and least likely to be harmed by the study interventions. MC 6076, Room M644, Chicago, IL 60637, jkrishna@medicine.bsd.uchicago.edu,. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Another feature of efficacy trials is the conduct of such studies in a research environment that promotes uniform application of the intervention to study subjects, often by expert clinicians and in resource intensive settings. The National Heart, Lung, and Blood Institutesponsored AsthmaNet, for example, is a multi-center network led by Principal Investigators with established research prog...

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Theophylline-associated status epilepticus in an infant: pharmacokinetics and the risk of suppository use

Abstract: The parents of children and also physicians should be educated to ensure the proper use of the suppository formula.

Cited by 6 publications

References 6 publications

Drug-induced status epilepticus

Drug-induced status epilepticus

Untitled

A call for action: Comparative effectiveness research in asthma

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