2013
DOI: 10.1186/1741-7015-11-14
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The young osteoarthritic knee: dilemmas in management

Abstract: As a result of increasing life expectancies, continuing physical careers, lifestyles into later life and rising obesity levels, the number of younger patients presenting with osteoarthritis (OA) of the knee is increasing. When conservative management options have been exhausted, the challenge for the orthopedic surgeon is to offer a procedure that will relieve symptoms and allow a return to a high level of function but not compromise future surgery that may be required as disease progresses or prostheses fail … Show more

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Cited by 44 publications
(44 citation statements)
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“…UBM is used clinically for several different applications including management of trauma wounds (29), chronic non-healing wounds (2), and esophageal reinforcement in gastrectomy (7). Because OA does not yet have a viable treatment, and UBM has shown promise in other musculoskeletal defects and degenerative diseases, the possibility of UBM to treat OA was tested here in a mouse model and in human primary cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…UBM is used clinically for several different applications including management of trauma wounds (29), chronic non-healing wounds (2), and esophageal reinforcement in gastrectomy (7). Because OA does not yet have a viable treatment, and UBM has shown promise in other musculoskeletal defects and degenerative diseases, the possibility of UBM to treat OA was tested here in a mouse model and in human primary cells.…”
Section: Discussionmentioning
confidence: 99%
“…The primary therapeutic treatment for OA is end-stage joint replacement, such as total-knee replacement surgery. These surgeries are invasive, and as severity of OA is increasing in younger patients, the comparably short lifetime of knee joint replacements present a challenge (2). The ultimate goal for OA treatment is to find a disease-modifying osteoarthritis drug (DMOAD) that can promote tissue regeneration, reduce or stop the progression of OA, and ultimately promote regeneration of the lost tissue.…”
Section: Introductionmentioning
confidence: 99%
“…Traditional systematic reviews, which are often focused on randomized controlled trials, usually do not allow one to uncover causal pathways or to identify contextual mechanisms that may explain whether, why, and how interventions might work [ 11 ]. Realist reviews have emerged as an alternative method for systematic reviews, aiming to provide answers for policy makers about the causal mechanisms that link context, intervention, and outcomes [ 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…Lastly, in younger patients a so-called ‘treatment gap’ for OA has been recognised 1. Due to high expectations, non-surgical treatment options for OA are unlikely to offer sufficient and lasting improvements to young patients with knee OA 2. Furthermore, surgical treatments such as arthroscopic debridement or knee replacement have limitations in long-term efficacy or appropriateness for the stage of the disease 1 3…”
Section: Introductionmentioning
confidence: 99%