The World Distribution of Transferrin Variants and some Unsolved Problems

Kirk, R. L.

doi:10.1017/s1120962300012488

Cited by 21 publications

(8 citation statements)

References 55 publications

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“…In addition to the C subtypes there are several more distinct allelic variants at the TF locus which have been reviewed by Kirk [1968] and Giblett [1969], Kirk's re view provides an excellent account of the worldwide distribution of these variants. Since then only a few more variants have been discovered and their distribution is limited [Rao et al, 1979;Ying et al, 1981;Weidinger et al, 1984], Some of these var iants are known to have gene frequencies of more than 1 % in at least one major pop ulation group, including TFDI, TF DChi, TF B2 and TF BO-I.…”

Section: Tf B and D Allelesmentioning

confidence: 99%

“…Since then extensive data on the distribution of TF alleles has been ac cumulated from different human popula tions around the world. Excellent reviews of this early work can be found in Kirk [1968], Giblett [1969] and Buettner-Janusch [1970], The most common pheno type in all human populations was desig nated as TF C. Variants which migrate fas ter than C at alkaline pH are known as TF B and those which migrate slower are termed TF D. More than 20 variants as well as a null allele have been detected by starch or agarose gel electrophoresis. The variants are controlled by multiple alleles at the single TF locus [Cooper, 1978;Rao et al, 1979;Ying et al, 1981;Weidinger et al, 1984].…”

Section: Introductionmentioning

confidence: 99%

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Human Transferrin Polymorphism

1987

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The application of isoelectric focussing (IEF) has revealed a large amount of heterogeneity in the human transferrin (TF) system and has enhanced its potential value in anthropological and genetic studies. The average heterozygosity has been elevated from 0.05, observed by conventional methods of electrophoresis, to 0.29 detected by IEF. So far approximately 30,000 individuals from 122 population groups have been analyzed for TF subtypes to evaluate the magnitude of genetic variation at the TF locus. Possible environmental and biological factors, which may be operating to maintain the TF polymorphism, are discussed.

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Section: Tf B and D Allelesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human Transferrin Polymorphism

1987

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“…Since Smithies (1957) detected genetic variants of TF by starch gel electrophoresis (SGE), electrophoretic variants of TF have been reported successively, and no less M. FUJITA et a [. than 22 types have been identified to date, but the frequency of every one of them is low (Kirk, 1968;Giblett, 1969;Sutton and Jamieson, 1972). In Japanese populations, Parker and Bearn (1961), Matsumoto (1964), Omoto and Harada (1972), and Kirk et al (1978) have reported rare electrophoretic variants.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic variants of blood proteins in Japanese VI. Transferrin

et al. 1985

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SummaryA multiplicity of transferrin variants have been detected in the course of the biochemical aspect of the study of the genetic effects of atomic bombs. Variants obtained from the studies of 19,770 individuals in Hiroshima and Nagasaki were compared by polyacrylamide slab gel electrophoresis using three kinds of buffer systems with different pH values and thin layer polyacrylamide gel isoelectric focusing. The variants were compared on the basis of their relative mobilities and isoelectric points; seven types of fast-moving variant (B-variant) and nine types of slow-moving variant (D-variant) were detected, involving a total of 154 and 273 individuals, respectively. All the variants were identified as genetic variants by family studies. No variant differed in allele frequency between the two cities. The variants detected in this study were compared with variants detected in residents of Mie district (another Japanese population), Caucasoids, American blacks, and Amerindians. Six additional types of Bvariant and four additional types of D-variant, which had not been detected in Hiroshima and Nagasaki, were identified.

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“…More than 20 different electrophoretic variants of the iron-binding protein, transferrin, have been detected in human serum from many parts of the world (Kirk, 1968;Giblett, 1969;Sutton and Jamieson, 1972). Among these populations the Japanese seem to have an unusual number of transferrin variants.…”

Section: Introductionmentioning

confidence: 99%

Transferrin variants in Korea and Japan

Kirk¹,

Matsumoto

Katayama

1978

Jap J Human Genet

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SummarySeveral transferrin variants detected in surveys of serum samples from Koreans and Japanese have been compared critically with standards and with each other using thin layer agarose gel electrophoresis and polyacrylamide gel electrophoresis.All slow-moving variants were found to have identical mobility with a reference sample of CDc~l. Four different fast-moving variants were detected, Bxoro~ 1, B• .... 2, Bj~p. 1 and Bj~p. 3. Their relative mobilities at pH 8.9 and 6.5 have been listed and compared with variants described by other investigators.

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The World Distribution of Transferrin Variants and some Unsolved Problems

Cited by 21 publications

References 55 publications

Human Transferrin Polymorphism

Human Transferrin Polymorphism

Electrophoretic variants of blood proteins in Japanese VI. Transferrin

Transferrin variants in Korea and Japan

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