The Weight of HLA-DPA1 rs3077 Single Nucleotide Polymorphism in Prostate Cancer, a Multicenter Study

Alenzi, Mohammed Jayed; Ghazy, Amany A.; Taha, Diaa‐Eldin

doi:10.1155/2021/5539851

Cited by 6 publications

(6 citation statements)

References 21 publications

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“…DNA purity and concentration were assessed using a NanoDrop spectrometer. Genotyping of HLA‐DPA1rs3077(A/G) and HLA‐DQ‐rs3920 ( A/G ) was done using real‐time PCR (Applied Biosystems‐Life Technologies, California, USA), as described by Alenzi et al (2021). In each run, three water samples were used as blank controls and five randomly selected samples were repeated (to test the consistency).…”

Section: Methodsmentioning

confidence: 99%

“…Various studies have reported a relation between HLA SNPs and different diseases such as gastric cancer (Huang et al, 2012; Lee et al, 2009; Li et al, 2005), breast cancer (Ghazy et al, 2014), ovarian cancer (Ghazy & El‐Etreby, 2016), prostate cancer (Alenzi et al, 2021) and viral infections (as HBV, HCV) (Ghazy et al, 2016, 2020). Such studies were conducted to evaluate either susceptibility, molecular pathogenesis, prognosis or response to treatment.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, HLA‐DPA1rs3077A and HLA‐DQ rs3920G were associated with an increased risk of ovarian cancer (Ghazy & El‐Etreby, 2016). However, the HLA‐DPA1rs3077G allele has a role in the occurrence of prostate cancer (Alenzi et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Ghazy

Taha

2022

Journal of Applied Microbiology

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Aims:The aim was to evaluate the role of HLA-DP/DQ single-nucleotide polymorphisms (SNPs) in Helicobacter pylori infection in Kafrelsheikh governorate, Egypt. Methods and results:The study enrolled 120 persons; 48 naïve H. pylori-infected patients, 42 relapsers and 30 H. pylori-free controls. Gastroscopy, H. pylori stool antigen, anti-CagA and anti-VacA antibodies were determined. Genotyping of HLA-DPA1rs3077 (A/G) SNP and HLA-DQ-rs3920(A/G) SNP was done using real-time PCR. The antibody profile against H. pylori showed that 85.7% of patients with recurrent infection have IgG against CagA (p = 0.001*). There was a significant association between the occurrence of H. pylori infection and both HLA-DPA1rs3077AA and HLA-DQ-rs3920AG genotypes. Concerning H. pylori relapse, the HLA-DQ-rs3920AG genotype was detected in 78.6% of patients with recurrent infection (p = 0.002*).Patients carrying this genotype tend to be relapsers 9.8 times more than patients carrying other genotypes.Conclusions: HLA-DPA1rs3077AA and/or HLA-DQ-rs3920AG genotypes could be risk factors for the occurrence of H. pylori infection. HLA-DQ-rs3920AG genotype is markedly linked to recurrent H. pylori infection.Significance and impact of the study: Host factors as HLA gene polymorphism could be a predisposing factor for susceptibility, recurrence or chronicity of H. pylori and should be studied in different ethnic groups.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Ghazy

Taha

2022

Journal of Applied Microbiology

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“…For any viral infection, viral antigen presentation and induction of cellular immunity occurs mainly through human leukocyte antigen (HLA). Recently, we have studied the role of HLA-DP/DQ polymorphisms in many diseases as ovarian cancer (7), hepatitis C virus (HCV) infection and response to treatment (8), Prostate cancer (PCa) (9), Helicobacter pylori recurrence (10), and type 1 diabetes mellitus (T1DM) (11). Results of these studies showed variable results; for example, HLA-DPrs3077G allele was more frequent among PCa patients than the control group (9).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we have studied the role of HLA-DP/DQ polymorphisms in many diseases as ovarian cancer (7), hepatitis C virus (HCV) infection and response to treatment (8), Prostate cancer (PCa) (9), Helicobacter pylori recurrence (10), and type 1 diabetes mellitus (T1DM) (11). Results of these studies showed variable results; for example, HLA-DPrs3077G allele was more frequent among PCa patients than the control group (9). However, HLA-DPrs3077A allele was associated with higher risk to ovarian cancer (7), HCV (8), H. pylori infection (10), and T1DM (11).…”

Section: Introductionmentioning

confidence: 99%

Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 Outcomes

Ghazy¹,

Alrasheedi²,

Elashri

et al. 2023

Br J Biomed Sci

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Background: Single nucleotide polymorphisms provide information on individuals’ potential reactions to environmental factors, infections, diseases, as well as various therapies. A study on SNPs that influence SARS-CoV-2 susceptibility and severity may provide a predictive tool for COVID-19 outcomes and improve the customized coronavirus treatment.Aim: To evaluate the role of human leukocyte antigens DP/DQ and IFNλ4 polymorphisms on COVID-19 outcomes among Egyptian patients.Participants and Methods: The study involved 80 patients with severe COVID-19, 80 patients with mild COVID-19, and 80 non-infected healthy volunteers. Genotyping and allelic discrimination of HLA-DPrs3077 (G/A), HLA-DQrs7453920 (A/G), and IFNλ4 rs73555604 (C/T) SNPs were performed using real-time PCR.Results: Ages were 47.9 ± 8, 44.1 ± 12.1, and 45.8 ± 10 years in severe, mild and non-infected persons. There was a statistically significant association between severe COVID-19 and male gender (p = 0.002). A statistically significant increase in the frequency of HLA-DPrs3077G, HLA-DQrs7453920A, and IFNλ4rs73555604C alleles among severe COVID-19 patients when compared with other groups (p < 0.001). Coexistence of these alleles in the same individual increases the susceptibility to severe COVID-19 by many folds (p < 0.001). Univariate and multivariate logistic regression analysis for the studied parameters showed that old age, male gender, non-vaccination, HLA-DQ rs7453920AG+AA, HLA-DPrs3077GA+GG, and IFNλ4rs73555604CT+CC genotypes are independent risk factors for severe COVID-19 among Egyptian patients.Conclusion: HLA-DQ rs7453920A, HLA-DPrs3077G, and IFNλ4rs73555604C alleles could be used as markers of COVID-19 severity.

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Diosgenin a steroidal compound: An emerging way to cancer management

Arya

Kumar

2021

J Food Biochem

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To endure respective research for cancer via common food ingredients has become more prominent with preferably minuscule toxicity. Spices are emerging as a new source of bioactive compounds which have the potential to cure cancer. Fenugreek is rich in diosgenin that has curative and preventive potency toward various cancers. Cancer is invading various cellular mechanisms by altering cellular receptors. Cancer falsifies healthy cells by altered cell receptors like p38, p53, mTOR, Akt, and PARP. Distinct stages of cancer development are triggered by various cellular mechanisms. Diosgenin helps in suppressing cancer mechanisms and induces programmed cell death. Diosgenin brought changes in treatment line of lung, breast, prostate, liver, and colon cancer. Apoptosis changes cytoplasmic different caspase pathways and triggers selected sequence for cancer cell line death. Cell death comprised of series of events carried out by metalloprotease caspase. The complex relationship among cancer, caspase, cell death, and cellular receptors is reviewed in this article in respect of diosgenin. The utilization of diosgenin in creating a bar for cancer, its triggering sites, and various ways to cause apoptosis of abnormal cells. This article focused on diosgenin, its role in the prevention of different cancer and cellular apoptosis throughout different pathways involved in complex interaction of bioactive compound‐cellular mechanism cancer. Practical applications The concept of curing diseases from daily routine food is quite old. Fenugreek is an excellent source of various bioactive compounds especially diosgenin. Diosgenin is steroidal sapogenin that cures various health issues including cancers. Cancer is one of the most life‐threating disease which can affect any cell, tissue, and organ in living system. Diosgenin is proved to be beneficial in terms curing cancer of various types but majorly include lung, liver, colon breast, and prostate. Cancer cure with diosgenin is providing a new base to the pharmaceutical and medical researchers to commence new and more specific journey of diosgenin. Diosgenin could alter cellular pathways that modify cell mechanism in way toward treating cancer. Cell mechanism mainly affected by the interaction of cell signals and cell different receptors that cause triggered cell death. This review article focused over various cancer and diosgenin effect in controlling different cellular pathways which include cellular signaling and cell death mechanism.

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The Weight of HLA-DPA1 rs3077 Single Nucleotide Polymorphism in Prostate Cancer, a Multicenter Study

Cited by 6 publications

References 21 publications

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 Outcomes

Diosgenin a steroidal compound: An emerging way to cancer management

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