The Virus Watch Program: A Continuing Surveillance of Viral Infection in Metropolitan New York Families: V. Observations in Employed Adults on Etiology of Acute Upper Respiratory Disease and Heterologous Antibody Response to Rhinoviruses12

Fawzy, Khairia Y.; Fox, John P.; Ketler, Albert; Brandt, Carl D.; Hall, Carrie E.; Haraway, Andrew W.

doi:10.1093/oxfordjournals.aje.a120774

Cited by 10 publications

(8 citation statements)

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“…Strains of RV 51 isolated in different years were shown to have antigenic variation (16). Several reports in the literature suggest that human beings show heterotypic antibody response after natural infection with rhinovirus (7,9,10).…”

Section: Resultsmentioning

confidence: 99%

Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera

et al. 1973

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Antisera produced in rabbits to 37 rhinovirus (RV) types have been examined for antibody to the 36 corresponding heterologous types. Reciprocal neutralization was noted between RV types 2 and 49 and RV types 13 and 41. Five additional monotypic rhinoviral rabbit antisera neutralized one heterologous rhinovirus. Neutralizing antibody titers against heterologous RV serotypes were similar to those shown in the RV 1A, 1B and RV 9, 32 reciprocal cross-reactions, and would not be expected to result in false identification of serotypes. Comparison of neutralizing antibody titers and neutralization rate constants in serial serum specimens of immunized rabbits showed that antibody response to the immunizing RV type and the cross-reacting type followed a similar time pattern.

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Section: Resultsmentioning

confidence: 99%

Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera

et al. 1973

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“…However, insufficient antigenic stimulus may be the reason for this, particularly since recent reports (FAwzY et al, 1967;FLEET et al, 1968) have confirmed an earlier isolated observation (HA~PARIA~ et al, 1964) that heterologous antibody responses do occur in humans after natural and induced rhinovirus infections. Titres of our rhinovirus vaccines before inactivation were 105--106 TCDs0/ml which are 10-to 100-fold lower than minimum pre-inactivation titres of poliovirus (Salk type) vaccines.…”

mentioning

confidence: 80%

Absence of heterologous antibody responses in human volunteers after rhinovirus vaccination

Stott

Draper

Stones

et al. 1969

Archiv f Virusforschung

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Early reports of low level cross-neutralization reactions among the rhinoviruses (HAlving, CON~LLu and P~OCXNOW, 1964; HA~XPAl~IA~ et al., 1964) have been confirmed and expanded by F~NTERS and colleagues (1966) who found low level hcterologous responses in cattle immunised with rhinoviruses. They also showed that injection of previously immunised cattle and guinea pigs with heterologous related rhinoviruses induced anamnestie responses. In view of the possible applications to rhinovirus vaccines in man we investigated the heterologous responses induced in man by vaccines made from three different rhinoviruses which induce heterologous responses in animals: rhinovirus 2 which induced antibody in cattle against rhinoviruses 4, 33 and 34; rhinovirus 34 which induced heterologous antibody against rhinovirus 4 and some cross-reaction with rhinovirus 14; rhinovirus 35 which induced heterologous antibody against rhinoviruses 3, 4 and 14 (Fs, NT~aS et al,, 1966; ttAMaE, personal communication).Rhinovirus 2 vaccines were prepared either as live vaccine from PK strain grown in human embryo kidney cells or as formalin-inactivated vaccine from ttGP strain grown in monkey kidney cells. These vaccines were administered and sera collected as previously described (Scientific Committee on Common Cold Vaccines, 1965).Rhinovirus types 34 and 35 vaccines were grown in WI-38 cells and inactivated with formalin. Volunteers received two intramuscular injections of 1 ml of these vaccines at about monthly intervals. Sera were collected at each injection and one month after the final injection. Sera were titrated

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“…Gwaltney & Jordan, 1966;Hamre, Connelly & Procknow, 1966;Phillips, Melnick & Grim, 1968) and families (e.g. Hendley, Gwaltney & Jordan, 1969;Fawzy et al 1967). These findings would indicate that a unit of 350 men with intakes of 30 fresh individuals at regular intervals is too small for the introduction of many new viruses or possesses too few susceptibles to support an outbreak.…”

Section: Association Of Virus With Clinical Illnessmentioning

confidence: 99%

Viruses associated with acute respiratory infections in Royal Air Force personnel

Higgins¹,

Ellis²,

Woolley³

et al. 1970

Epidemiol. Infect.

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SUMMARYAll respiratory illnesses which were reported to the medical officers between September 1966 and December 1967 on a Royal Air Force station of 350 men were studied virologically.Three periods of increased respiratory infections were observed: two occurred in the autumn, one in each year, and the third in the winter during January and February. The autumnal outbreaks were associated mainly with rhinovirus infections, and high isolation rates (82.1, 65-9 00) were achieved at these times. Few of the illnesses during the winter outbreak could be diagnosed in the laboratory, and no evidence was found of infection with 'coronaviruses'.Despite the entrance of 30 fresh recruits direct from civilian life every 5 weeks, the respiratory infections encountered on the station were very similar to those in the local population and were not predominantly infections with adenoviruses, Coevirus, and Mycoplasma pneumoniae, as previously reported from larger military recruit centres.

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The Virus Watch Program: A Continuing Surveillance of Viral Infection in Metropolitan New York Families: V. Observations in Employed Adults on Etiology of Acute Upper Respiratory Disease and Heterologous Antibody Response to Rhinoviruses12

Cited by 10 publications

References 0 publications

Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera

Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera

Absence of heterologous antibody responses in human volunteers after rhinovirus vaccination

Viruses associated with acute respiratory infections in Royal Air Force personnel

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