The vascular endothelial growth factor +405 G/C polymorphism in psoriasis

Wu, Jie; Ren, Xia; Zhang, Xuelong; Li, Chunxiang; Li, Yuzhen; Ma, Hongyu; Zhou, Yucheng; Jin, Yan; Chen, Feng; Bai, Jing; Fu, Songbin

doi:10.1016/j.jdermsci.2009.10.009

Cited by 12 publications

(17 citation statements)

References 9 publications

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“…Ten studies were identified by electronic and manual searching and all 10 were selected for full-text review based on title and abstract details (Young et al, 2004(Young et al, , 2006Barile et al, 2006;Butt et al, 2007;Lee et al, 2008;Stefanaki et al, 2008;Wang et al, 2008;Wongpiyabovorn et al, 2008;Wu et al, 2010;Zablotna et al, 2013). However, 3 of the 10 were excluded because they had no control group or did not contain genotype data (Young et al, 2006;Lee et al, 2008;Stefanaki et al, 2008).…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…However, 3 of the 10 were excluded because they had no control group or did not contain genotype data (Young et al, 2006;Lee et al, 2008;Stefanaki et al, 2008). Thus, 7 studies met the study inclusion criteria, and these studies included a total 1956 subjects (psoriasis 665, controls 1291) and consisted of European and Asian populations (Young et al, 2004;Barile et al, 2006;Butt et al, 2007;Wang et al, 2008;Wongpiyabovorn et al, 2008;Wu et al, 2010;Zablotna et al, 2013) (Table 1).…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Particularly, the +405 C/G polymorphism in the 5'-untranslated region and 3 polymorphisms in the promoter region (-460 C/T, -1154 A/G, and -2578 A/C) have been associated with VEGF production (Young et al, 2006). Previous studies showed that these polymorphisms are associated with several autoimmune diseases, including psoriasis, while other reports found no such associations (Young et al, 2004;Barile et al, 2006;Butt et al, 2007;Wang et al, 2008;Wongpiyabovorn et al, 2008;Wu et al, 2010;Zablotna et al, 2013). The reasons for these disparities may be small sample sizes, low statistical power, and/or clinical heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

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Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis

Lee

Song

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibility to psoriasis. Meta-analyses were conducted to examine the associations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and recessive, dominant, and additive models. Seven studies on VEGF polymorphisms and psoriasis involving 1956 subjects (psoriasis patients 665, controls 1291) were included in this meta-analysis. We observed no association between psoriasis and the VEGF +405 C allele in all study subjects (odds ratio = 0.984, 95% confidence interval = 0.754-1.285, P = 0.906), but stratification by ethnicity indicated a significant association between the VEGF +405 C allele and psoriasis in Asians (odds ratio = 0.762, 95% confidence interval = 0.628-0.923, P = 0.005). In addition, we observed a significant association between the VEGF -460 C allele and psoriasis in Europeans (odds ratio = 0.807, 95% confidence interval = 0.672-0.968, P = 0.021). Meta-analyses of the -1154 A/G polymorphism also revealed a significant association with psoriasis in

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Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis

Lee

Song

2015

Genet. Mol. Res.

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“…In accordance with the inclusion criteria, nine case-control studies (Young et al, 2004;Barile et al, 2006;Butt et al, 2007;Wang et al, 2008;Wongpiyabovorn et al, 2008;Lu et al, 2009;Wu et al, 2010;Zablotna et al, 2013;Xu et al, 2013) with 2531 psoriasis cases and 2670 healthy controls were included in this meta-analysis and 87 were excluded. The flow diagram of the selection of studies and specific reasons for exclusion from the meta-analysis are shown in Figure 1.…”

Section: The Characteristics Of Included Studiesmentioning

confidence: 99%

“…Conversely, another study by Barile et al (2006) demonstrated that -460CC homozygous genotype but not + 405C > G were associated with an increased risk in developing psoriasis for Italians. Yet, two more recent studies in China reported that + 405C > G was significantly associated with psoriasis risk Wu et al, 2010). Previous studies in this field have limited sample sizes and their lack of standardization makes their results difficult to generalize.…”

mentioning

confidence: 99%

Four Polymorphisms ofVEGF(+405C>G, −460T>C, −2578C>A, and −1154G>A) in Susceptibility to Psoriasis: A Meta-Analysis

Huang

Zhou

et al. 2014

DNA and Cell Biology

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Polymorphism of VEGF gene in susceptibility to chronic immune-mediated inflammatory diseases: a meta-analysis

Chen

Xue³

et al. 2015

Rheumatol Int

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Background Vascular endothelial growth factor (VEGF) is an important angiogenic factor and may be connected with chronic immune-mediated inflammatory diseases (IMIDs) to some extent. However, previous researches about the relationship between the +405G>C (dbSNP: rs2010963) polymorphism in VEGF gene and the risk of IMIDs are controversial and inconsistent. So we conducted this meta-analysis to assess whether the relationship between the +405G>C polymorphism in the 5'-UTR region of VEGF gene and IMID susceptibility exists. Methods Our literature search was conducted on the PubMed, Embase, Web of science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases to retrieve for eligible studies. Odds ratios as well as their 95 % confidence intervals were utilized to deduce the possible relationship. Results A total number of 5175 patients with IMIDs and 7069 healthy controls from 27 case-control studies were included. For the overall eligible data collected in our meta-analysis, there was no marked relationship between +405G>C polymorphism and the risk of IMIDs. However, subgroup analysis by ethnicity suggested that +405C allele could be a protective factor for IMIDs in Asians, whereas an opposite conclusion was drawn in Caucasians. Conclusion Thus, we may come to the conclusion that the VEGF +405G>C polymorphism could be associated with IMIDs, and the correlation might vary with ethnic groups.

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The vascular endothelial growth factor +405 G/C polymorphism in psoriasis

Cited by 12 publications

References 9 publications

Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis

Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis

Four Polymorphisms ofVEGF(+405C>G, −460T>C, −2578C>A, and −1154G>A) in Susceptibility to Psoriasis: A Meta-Analysis

Polymorphism of VEGF gene in susceptibility to chronic immune-mediated inflammatory diseases: a meta-analysis

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