Polymorphism of VEGF gene in susceptibility to chronic immune-mediated inflammatory diseases: a meta-analysis

Abstract

Background Vascular endothelial growth factor (VEGF) is an important angiogenic factor and may be connected with chronic immune-mediated inflammatory diseases (IMIDs) to some extent. However, previous researches about the relationship between the +405G>C (dbSNP: rs2010963) polymorphism in VEGF gene and the risk of IMIDs are controversial and inconsistent. So we conducted this meta-analysis to assess whether the relationship between the +405G>C polymorphism in the 5'-UTR region of VEGF gene and IMID susceptibility exists. Methods Our literature search was conducted on the PubMed, Embase, Web of science, Chinese National Knowledge Infrastructure, and Chinese Biomedical databases to retrieve for eligible studies. Odds ratios as well as their 95 % confidence intervals were utilized to deduce the possible relationship. Results A total number of 5175 patients with IMIDs and 7069 healthy controls from 27 case-control studies were included. For the overall eligible data collected in our meta-analysis, there was no marked relationship between +405G>C polymorphism and the risk of IMIDs. However, subgroup analysis by ethnicity suggested that +405C allele could be a protective factor for IMIDs in Asians, whereas an opposite conclusion was drawn in Caucasians. Conclusion Thus, we may come to the conclusion that the VEGF +405G>C polymorphism could be associated with IMIDs, and the correlation might vary with ethnic groups.

Role of tumor microenvironment in tumorigenesis

“…As depicted in Figure 2, CAFs 96, NE cells 97, adipose cells 98-100, and inflammatory cells 101-103 in the TME can affect the role of immune cells through the secretion of different cytokines, cell factors, or interacting proteins, which adds several difficulties to the search for markers and targets for cancer therapy 104, 105. In different cell and tumor types, the complexity and heterogeneity of immune factors also provides a further complication to finding more specific markers of the immune cells.…”

The VEGFA ‐1154G/A polymorphism is associated with reduced risk of rheumatoid arthritis but not with systemic lupus erythematosus in Mexican women

“…By contrast, other studies have shown reduced risk with the VEGFA ‐634G/C SNP. Indeed, a meta‐analysis showed that this polymorphism was associated with decreased risk with respect to immune‐mediated inflammatory diseases in Asians . On the other hand, we identified an association between the VEGFA ‐1154G/A polymorphism and reduced risk of developing RA in the Mexican population.…”

Is the +405 G/C single nucleotide polymorphism of the vascular endothelial growth factor (VEGF) gene associated with late‐onset vitiligo?

“…Three meta‐analyses investigating the association between autoimmune diseases and VEGF polymorphism have concluded that there is a relationship between + 405G/C polymorphism in VEGF and susceptibility to immune‐mediated inflammatory diseases (Che et al, ; Chen et al, ; Wei et al, ). In this study, we speculated that vitiligo may imitate other autoimmune disorders by sharing some of the susceptibility genes and polymorphisms.…”