The value of the injection method in the study of lymphatic development

Kampmeier, Otto F.

doi:10.1002/ar.1090060602

Cited by 51 publications

(26 citation statements)

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“…Incorporation of scattered cells (''lymphangioblasts'') to a growing lymphatic vessel wall would be consistent with an alternative, centripetal, theory on the origin of lymphatic vessels. This theory posits that lymphatics derive from mesoderm-derived endothelial precursors and secondarily establishes their vessel connection (Huntington and McClure, 1910;Kampmeier, 1912). The possibility of this process has been confirmed by our own and others' (Buttler et al, 2006) recent observations.…”

Section: Developmental Dynamicsmentioning

confidence: 66%

Cellular phenotypes and spatio‐temporal patterns of lymphatic vessel development in embryonic mouse hearts

Flaht

Jankowska‐Steifer

Radomska

et al. 2012

Developmental Dynamics

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Di‐stereoblock polylactides (di‐sb‐PLA: PLLA‐b‐PDLA) having high molecular weight (Mn > 100 kDa) were successfully synthesized by two‐step ring‐opening polymerization (ROP) of L‐ and D‐lactides using tin(2‐ethylhexanoate) as a catalyst. By optimizing the polymerization conditions, the block sequences were well regulated at non‐equivalent feed ratios of PLLA and PDLA. This synthetic method consisted of three stages: (1) polymerization of either L‐ or D‐lactide to obtain a PLLA or PDLA prepolymer with a molecular weight less than 50 kDa, (2) purification of the obtained prepolymer to remove residual lactide, and (3) polymerization of the enantiomeric lactide in the presence of the purified prepolymer. Their 13C and 31P NMR spectra of the resultant di‐sb‐PLAs strongly supported their di‐stereo block structure. These di‐sb‐PLAs, having weight‐average molecular weights higher than 150 kDa, were fabricated into polymer films by solution casting and showed exclusive stereocomplexation. The thermomechanical analysis of the films revealed that their heat deformation temperature was limited probably because of their low crystallinity owing to the non‐equivalent PLLA/PDLA ratio. The blend systems of the di‐sb‐PLAs having complementary stereo‐sequences (the one with a long PLLA block and the other with long PDLA block) were also prepared and characterized to enhance the sc crystallinity. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 794–801, 2010

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Section: Developmental Dynamicsmentioning

confidence: 66%

Cellular phenotypes and spatio‐temporal patterns of lymphatic vessel development in embryonic mouse hearts

Flaht

Jankowska‐Steifer

Radomska

et al. 2012

Developmental Dynamics

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“…This theory is based on the assumption that the peripheral lymphatic vessels develop from putative mesenchymal lymphangioblasts [18,40]. The confluence of mesenchymal clefts leads to the formation of lymphatic vessels that fuse with the veins due to centripetal growth (Fig.…”

Section: Theory Of Centripetal Developmentmentioning

confidence: 99%

Pathogenesis of lymphangiomas

et al. 2008

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Based on various hypotheses concerning lymphangiogenesis published in the literature, different putative mechanisms of lymphangioma development are discussed including failure of the lymphatic system to connect with or separate from the venous system, abnormal budding of the lymphatic system from the cardinal vein, or acquired processes such as traumata, infections, chronic inflammations, and obstructions. Increasingly, the possible influence of lymphangiogenic growth factors on the development of lymphangiomas is discussed. The proved expression of different growth factors in the endothelium of lymphangiomas leads to new hypotheses regarding the pathogenesis of lymphangiomas. Thus, further studies on the lymphangiogenesis and the development of lymphangiomas will have to clarify as to whether lymphangiomas are true malformations or neoplastic in nature.

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“…Other studies suggested that the connection of the lymphatic and venous systems was secondary. They proposed that lymphatic stem cells, called lymphangioblasts, invaded the mesenchyme in order to form primitive lymphatic sacs (Huntington and McClure, 1908;Kampmeier, 1912). Recent work using chick embryo limb buds has shown that lymphatic vessels can be derived both by sprouting of vessels from the cardinal vein and by mesodermal lymphangioblasts (Schneider et al, 1999;Wilting et al, 2001;Wilting et al, 2000).…”

Section: Formation Of the Lymphatic Vascular Systemmentioning

confidence: 99%

Vascular development: from precursor cells to branched arterial and venous networks

Eichmann¹,

Li²,

Moyon³

et al. 2005

Int. J. Dev. Biol.

141

113

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The adult vascular system is composed of an arterial, a venous and a lymphatic compartment. These different compartments respectively provide oxygen and nutrients to peripheral organs, remove carbon dioxide and waste products and maintain an immune barrier to defend the host against foreign organisms. Malfunctions of the vascular system represent a major cause of mortality and disease in developed countries. Understanding of the molecular mechanisms regulating vascular system development and maintenance is thus crucial for the design of therapies to cure vascular diseases. The molecules implicated in the control of physiological and pathological angiogenesis in the adult already function during embryonic development. Indeed, the survival of the embryo also critically depends on the establishment of a functional circulatory loop. Here we review our current knowledge about the emergence of endothelial precursor cells in the embryo, of their assembly into the primary vascular plexus and of the remodeling of this plexus into arteries and veins. We also focus on the molecular mechanisms controlling the development of arteries, veins and lymphatic vessels.

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The value of the injection method in the study of lymphatic development

Cited by 51 publications

References 0 publications

Cellular phenotypes and spatio‐temporal patterns of lymphatic vessel development in embryonic mouse hearts

Cellular phenotypes and spatio‐temporal patterns of lymphatic vessel development in embryonic mouse hearts

Pathogenesis of lymphangiomas

Vascular development: from precursor cells to branched arterial and venous networks

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