Pathogenesis of lymphangiomas

Wiegand, Susanne; Eivazi, Behfar; Barth, Peter; Rautenfeld, D. Berens von; Folz, Benedikt J.; Mandic, Robert; Werner, Jochen A.

doi:10.1007/s00428-008-0611-z

Cited by 145 publications

(113 citation statements)

References 46 publications

(60 reference statements)

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“…However, in the present clinical case, the location of the lesion was in the neck area. This is in concordance with lymphatic malformations in humans that occur most commonly in children, and two-thirds of all reported cases are found in the head and neck (Grasso et al 2008;Wiegand et al 2008;Colbert et al 2013).…”

Section: Discussionsupporting

confidence: 76%

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confidence: 99%

“…Some authors classified lymphangiomas as being: capillary (or simplex), cavernous, and cystic lymphangiomas (Yildirim et al 2004;Wiegand et al 2008). There are other classifications based on morphological aspects and they are divided into: macrocystic, microcystic and combined lymphagiomas (Wiegand et al 2008). Currently, LMs are classified into two categories: "vascular tumours" and "vascular malformations" based upon clinical, histological and biochemical differences (Wiegand et al 2008;Perkins et al 2010).…”

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confidence: 99%

“…There are other classifications based on morphological aspects and they are divided into: macrocystic, microcystic and combined lymphagiomas (Wiegand et al 2008). Currently, LMs are classified into two categories: "vascular tumours" and "vascular malformations" based upon clinical, histological and biochemical differences (Wiegand et al 2008;Perkins et al 2010). It has not been formally demonstrated that LMs are malignant disorders, and despite their unclear aetiology, some observations suggest a genetic aetiology because up to 40% of LMs detected during foetal development occur in children who present chromosomal anomalies (Perkins et al 2010).…”

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Lamb congenital lymphatic malformation - a case report

et al. 2014

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Lymphatic malformations have been rarely reported in literature either in humans or in animals. However, in recent years, concern about these malformations in humans has increased. A five-month-old Rasa Aragonesa male lamb was received at the Ovine Clinical Service of the Veterinary Faculty of Zaragoza, Spain, with a history of cervical protuberances coming from birth. The lamb showed three round swollen lumps (5-12 cm in diameter) parallel to the trachea on the left side of the neck. Clinical examination, haematology, ultrasonography, fluid examination and histopathology were performed. No abnormalities were found in blood samples and ultrasound confirmed a multicystic lesion with internal separations. Histological evaluation of the tissue revealed dilated lymphatic vessels and channels in the dermis and hypodermis; some lymphatic vessels were filled with amorphous proteinaceous material and occasional lymphocytes and macrophages. These protuberances were diagnosed as congenital lymphatic malformations. Most of the gross and microscopical lesions were very similar to those described in humans. To the authors' knowledge, this is the first time that a congenital lymphatic malformation is described in sheep.

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confidence: 76%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Lamb congenital lymphatic malformation - a case report

et al. 2014

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“…Lorsque leur étendue est importante ou qu'il existe un aspect angiomateux, la prise en charge de ces malformations doit être discutée lors de consultations pluridisciplinaires (dermatologue, chirurgien, radiologue interventionnel, pédiatre…) et le patient doit bénéficier d'un bilan d'extension même pour une lésion semblant superficielle [17]. En effet, les ML peuvent évoluer sur un mode dissimulé, avec une infiltration en profondeur des tissus [10]. L'imagerie par résonance magnétique est le meilleur examen pour visualiser l'extension dans les parties molles [18].…”

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Les malformations lymphatiques de la cavité orale, cas cliniques et revue de littérature

Rochefort

Lescaille

Hervé

et al. 2017

Med Buccale Chir Buccale

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Résumé -Introduction : Les malformations lymphatiques (ML) sont congénitales et non régressives. Elles résul-tent d'une anomalie de la morphogenèse embryologique vasculaire et sont détectées dans 80 % des cas avant l'âge de 2 ans, exceptionnellement à l'âge adulte. Asymptomatiques, elles sont le plus souvent diagnostiquées suite à une gêne fonctionnelle. Bien que d'aspects cliniques très hétérogènes, elles se regroupent en deux formes cliniques à distinguer, macrokystiques et microkystiques, dont les traitements et les pronostics diffèrent. L'aspect clinique de la lésion et la symptomatologie sont essentiels pour l'établissement du diagnostic mais aussi pour la décision thérapeutique. Bien qu'une surveillance clinique régulière soit souvent suffisante, une intervention thérapeutique est parfois nécessaire. Observations cliniques : Quatre cas de ML orales avec des aspects cliniques très hétéro-gènes sont présentés. L'un est situé au niveau de l'espace masticateur et de la fosse infratemporale avec une expression muqueuse à la commissure intermaxillaire, deux au niveau des muqueuses jugales et labiales, le quatrième au niveau de la langue. Discussion : Pour trois d'entre eux, le diagnostic a été réalisé à l'âge adulte et ceuxci ne présentaient aucun antécédent de ML. Deux ont été traités par laser, un par chirurgie, le dernier a bénéficié d'une surveillance clinique régulière. Conclusion : Ces quatre cas cliniques sont particulièrement représentatifs de l'hétérogénéité clinique buccale et thérapeutique de ces malformations.Abstract -Oral lymphatic malformations, case reports and review of the literature. Introduction: Lymphatic malformations (LMs) are congenital and non-regressive lesions. These lesions are due to embryological vascular morphogenesis abnormality. Most of them (80 %) are detected before 2 years old, and thus they are rarely found in adults. They are asymptomatic, so their diagnosis is often linked to functional discomfort. There are two clinical aspects with different prognoses: macrocystic and microcystic. Clinical aspects and symptomatology are essential for positive diagnosis and therapeutic decisions. For most cases, simple clinical observation is advised. However, in other cases associated with aesthetic or functional discomfort, therapeutic intervention is recommended, most of the time with sclerotherapy or surgery. Clinical observation: We present four patients with different types of lymphatic malformation: one is on the intermaxillary commissure, the second is on the cheek mucosa, the third is on the lip and the fourth is on the tongue. Discussion: For three of them, the diagnosis was established in adulthood with no past history of LMs. Two patients were treated by laser, one with surgery and for the last one, clinical follow-up was established. Conclusion: These four case reports are representative oral illustrations of the clinical aspects and therapeutic heterogeneity of this pathology.

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Microcystic Lymphatic Malformations of the Tongue

Wiegand¹,

Eivazi²,

Zimmermann³

et al. 2009

Arch Otolaryngol Head Neck Surg

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The initial stage seems to predict outcome. Carbon dioxide laser therapy provides good results primarily in stages I and IIA lymphatic malformations. In advanced lymphatic malformations (stages IIB, III, and IV), an interdisciplinary approach is necessary, because complete surgical excision is often impossible owing to the diffuse growth behavior, and therefore recurrence and persistence are common.

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Pathogenesis of lymphangiomas

Cited by 145 publications

References 46 publications

Lamb congenital lymphatic malformation - a case report

Lamb congenital lymphatic malformation - a case report

Les malformations lymphatiques de la cavité orale, cas cliniques et revue de littérature

Microcystic Lymphatic Malformations of the Tongue

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