The value of coronary artery calcium score assessed by dual-source computed tomography coronary angiography for predicting presence and severity of coronary artery disease

Almasi, Alireza; Pouraliakbar, Hamidreza; Sedghian, Ahmad; Karimi, Meghdad; Firouzi, Ata; Tehrai, Mahmood

doi:10.12659/pjr.890809

Cited by 12 publications

(11 citation statements)

References 25 publications

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“…Overall, there were great controversies in this regard. The results of two different studies from our region were not similar either [13,14]. Thus, we aimed to evaluate the usefulness of this score for predicting CAD, its severity and CAD-related risk factors in our population.…”

Section: Discussionmentioning

confidence: 97%

“…Some authors suggested that it could be a good predicting factor for mild to moderate stenosis [13]. Others have reported that it has insufficient predictive value [14].…”

Section: Discussionmentioning

confidence: 99%

“…The results of two recent regional studies were not similar either [13,14]. Almasi et al evaluated the value of CACS for predicting the presence and severity of CAD among 202 patients.…”

Section: Discussionmentioning

confidence: 99%

“…They reported a cutoff value of 350 for CACS for predicating coronary artery involvement. They concluded that this score could be used as an additional filter prior to CCTA among suspected patients, especially those with mild to moderate CAD risk factors [13]. …”

Section: Discussionmentioning

confidence: 99%

“…There are also some studies evaluating the prognostic value of CACS for determining the presence and severity of CAD [13,14]. There are controversies regarding the usefulness of CACS for predicting coronary artery stenosis.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of Coronary Artery Calcium Score for Determination of Presence and Severity of Coronary Artery Disease

et al. 2018

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SummaryBackgroundThere are controversies regarding the usefulness of coronary artery calcium score (CACS) for predicting coronary artery stenosis. The aim of this study was to determine the prognostic value of CACS for determining the presence and severity of coronary artery disease (CAD) in patients with sign and symptoms of the disease.Material/MethodsIn this cross-sectional study, 748 consecutive patients with suspected CAD, referred for coronary computed tomography angiography (CCTA), were enrolled. The mean CACS was compared between patients with different severities of coronary artery stenosis. The association between CACS and different CAD risk factors was determined as well. Different cutoff points of CACS for discriminating between different levels of coronary artery stenosis was determined using receiver operating characteristic (ROC) curves.ResultsThe mean CACS was significantly different between different levels of coronary artery stenosis (P<0.001) and there was a significant positive association between the severity of CAD and CACS (P<0.001,r=0.781). ROC curve analysis indicated that the optimal cutoff point for discriminating between CAD (presence of stenosis) and the non-stenosis condition was 5.35 with 88.6% sensitivity and 86.2% specificity. Area under the curve for different levels of coronary artery stenosis did not have sufficient sensitivity and specificity for discriminating between different levels of CAD severity (<70%).ConclusionsThe study demonstrated that there is a significant association between CACS and the presence as well as the severity of CAD. CACS could have an appropriate prognostic value for the determination of coronary artery stenosis but not for discriminating between different severities of stenoses.

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Section: Discussionmentioning

confidence: 97%

“…Some authors suggested that it could be a good predicting factor for mild to moderate stenosis [13]. Others have reported that it has insufficient predictive value [14].…”

Section: Discussionmentioning

confidence: 99%

“…The results of two recent regional studies were not similar either [13,14]. Almasi et al evaluated the value of CACS for predicting the presence and severity of CAD among 202 patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of Coronary Artery Calcium Score for Determination of Presence and Severity of Coronary Artery Disease

et al. 2018

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QCT Volumetric Bone Mineral Density and Vascular and Valvular Calcification: The Framingham Study

Chan

Cupples

Kiel

et al. 2015

Journal of Bone and Mineral Research

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There is increasing evidence that bone and vascular calcification share common pathogenesis. Little is known about potential links between bone and valvular calcification. The purpose of this study was to determine the association between spine bone mineral density (BMD) and vascular and valvular calcification. Participants included 1317 participants (689 women, 628 men) in the Framingham Offspring Study (mean age 60 years). Integral, trabecular, and cortical volumetric bone density (vBMD) and arterial and valvular calcification were measured from computed tomography (CT) scans and categorized by sex-specific quartiles (Q4 = high vBMD). Calcification of the coronary arteries (CAC), abdominal aorta (AAC), aortic valve (AVC), and mitral valve (MVC) were quantified using the Agatston Score (AS). Prevalence of any calcium (AS >0) was 69% for CAC, 81% for AAC, 39% for AVC, and 20% for MVC. In women, CAC increased with decreasing quartile of trabecular vBMD: adjusted mean CAC = 2.1 (Q4), 2.2 (Q3), 2.5 (Q2), 2.6 (Q1); trend p = 0.04. However, there was no inverse trend between CAC and trabecular vBMD in men: CAC = 4.3 (Q4), 4.3 (Q3), 4.2 (Q2), 4.3 (Q1); trend p = 0.92. AAC increased with decreasing quartile of trabecular vBMD in both women (AAC = 4.5 [Q4], 4.8 [Q3], 5.4 [Q2], 5.1 [Q1]; trend p = 0.01) and men (AAC = 5.5 [Q4], 5.8 [Q3], 5.9 [Q2], 6.2 [Q1]; trend p = 0.01). We observed no association between trabecular vBMD and AVC or MVC in women or men. Finally, cortical vBMD was unrelated to vascular calcification and valvular calcification in women and men. Women and men with low spine vBMD have greater severity of vascular calcification, particularly at the abdominal aorta. The inverse relation between AAC and spine vBMD in women and men may be attributable to shared etiology and may be an important link on which to focus treatment efforts that can target individuals at high risk of both fracture and cardiovascular events.

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Machine Learning-based Algorithm Enables the Exclusion of Obstructive Coronary Artery Disease in the Patients Who Underwent Coronary Artery Calcium Scoring

et al. 2020

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The value of coronary artery calcium score assessed by dual-source computed tomography coronary angiography for predicting presence and severity of coronary artery disease

Cited by 12 publications

References 25 publications

Prognostic Value of Coronary Artery Calcium Score for Determination of Presence and Severity of Coronary Artery Disease

Prognostic Value of Coronary Artery Calcium Score for Determination of Presence and Severity of Coronary Artery Disease

QCT Volumetric Bone Mineral Density and Vascular and Valvular Calcification: The Framingham Study

Machine Learning-based Algorithm Enables the Exclusion of Obstructive Coronary Artery Disease in the Patients Who Underwent Coronary Artery Calcium Scoring

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