The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients

Onaran, İlhan; Tezcan, Gülçin; Özgönenel, Levent; Cetin, Esra; Özdemir, Alper Tunga; Kanıgür-Sultuybek, Gönül

doi:10.1007/s00296-008-0772-8

Cited by 8 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All of these lines of evidence [12,15,27,28] imply a linkage between PARP-1 and RA, but in our study, we found no significant linkage between PARP-1 polymorphisms and RA in a Korean population. The SNPs, which were used to investigate associations with RA in Koreans, were compared with those used in previous studies (Table 5) [15,17]. The C1362T SNP used in the Spanish study [15] was identical to rs1341336 used in our study.…”

Section: Discussionmentioning

confidence: 99%

“…However, in a case-control study in Turkish patients with RA, the Val762Ala polymorphism in the PARP-1 gene, which causes a decrease in enzymatic activity, was not associated with RA susceptibility [16,17]. Also, previous study [18] investigating Korean patients with systemic lupus erythematosus (SLE) reported a significant relationship between PARP-1 polymorphisms and inflammatory arthritis.…”

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population

et al. 2010

View full text Add to dashboard Cite

Several studies have investigated the roles of genetic polymorphisms in rheumatoid arthritis (RA). Some of these studies reported that polymorphisms of poly(ADPribose) polymerase 1 gene (PARP-1) are linked to rheumatoid arthritis. Poly(ADP-ribose) polymerase is an enzyme involved in DNA repair, genomic stability, apoptosis, gene transcription, proliferation, and autoimmunity. To determine whether genetic polymorphisms of PARP-1 are related to rheumatoid arthritis in a Korean population, six single nucleotide polymorphisms (SNPs), which were selected based on LDs and minor allele frequency (MAF [ 0.05) in our previous study, were genotyped in 1,202 patients with rheumatoid arthritis and 979 unrelated healthy controls. As a result, no significant association between the susceptibility to rheumatoid arthritis and PAPR-1 polymorphisms was found. However, in further analysis depending on the radiological severity of rheumatoid arthritis, one PARP-1 polymorphism, rs1805413 (OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P corr = 0.04), and one haplotype (ht6, OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P corr = 0.04) were significantly associated with the radiological severity risk of RA in a recessive model. In addition, a recessive model revealed a correlation between one RA haplotype (ht4) and anti-CCP antibody negativity (OR 0.24, 95% CI 0.10-0.63, P = 0.003; P corr = 0.02). Despite a possible association between PARP-1 and the radiological severity of RA, this study found no statistical association between PARP-1 polymorphisms and the susceptibility to rheumatoid arthritis in a Korean population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Our previously published data suggest, rs1136410, the polymorphic marker localized to the coding region of the PARP-1 gene, is not related to development of RA in Turkish population [10] (Tables 1 and 2). In other clinical study, AA (mutant) genotype in rs1136410 has shown to be related with arthritis in 350 Korean SLE patients and 330 healthy controls [71].…”

Section: Nfkb1 and Parp-1 Polymorphisms In Relation To Inflammatory Dmentioning

confidence: 99%

“…Rheumatoid arthritis and systemic lupus erythematosus RA and SLE are complex diseases characterized by chronic inflammation with contributions of systemic autoimmunity [10,70]. The PARP-1 and NFKB1 genes may be the suitable candidate genes for investigating autoimmune and inflammatory disorders such as RA and SLE as genetic aspect.…”

Section: Nfkb1 and Parp-1 Polymorphisms In Relation To Inflammatory Dmentioning

confidence: 99%

“…rs1136410 results in the substitution of alanine (Ala) for valine (Val) at codon 762 in the catalytic domain has been searching in susceptibility to many inflammatory situations for years [10][11][12]. The polymorphisms of the promoter region (-410 C/T (rs2793378) and -1672 G/A (rs7527192)) in PARP-1 gene have been also investigating in the inflammatory situations [13,14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A General Sight about Linking PARP-1 and NFKB1 Variations to the Inflammatory Events

Gk¹,

Yenmiş²,

Koc³

2014

Interdiscip J Microinflammation

View full text Add to dashboard Cite

Poly (ADP-ribose) polymerase-1 (PARP-1) has various roles in cellular processes such as DNA repair, genomic stability, transcription, stress response, and cell death via regulating death and inflammation signalling pathways. On the other hand, PARP-1 inhibition has been shown to provide benefits in experimental models of animals with inflammatory diseases such as asthma, atherosclerosis and diabetes. PARP-1 also acts a transcriptional coactivator of nuclear factor kappa B (NFKB). The NFKB is a ubiquitous transcription factor that controls the expression of genes encoding cell adhesion molecules, growth factors, cytokines, and some acute phase proteins. Inappropriate activation of NFKB has been mostly searched with inflammatory events. In complete and persistent inhibition studies of NFKB, apoptosis, inappropriate immune cell development and delayed cell growth were investigated. These findings might provide new perceptions in the pathogenesis of inflammatory disorders regarding the roles of PARP-1 and NFKB1 proteins. In this review, we focus on some variations (rs28362491, rs696, rs1136410, rs2793378, rs7527192) of PARP-1 and NFKB1 genes in relation to susceptibility to common inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus, allergic rhinitis, Graves' disease, Hashimoto's thyroiditis, asthma and Behcet's disease.

show abstract

The role of base excision repair in pathogenesis of breast cancer in the Polish population

Cuchra

Mucha

Markiewicz

et al. 2015

Molecular Carcinogenesis

View full text Add to dashboard Cite

Breast cancer (BC) is leading type of cancer among group of women, which determines almost 23% of invasive cancers. It has been reported repeatedly that the level of oxidative stress is higher for BC in comparison to cancer-free woman. The goal of the present study was to evaluate the role of base excision repair (BER) pathway in the development of BC. One-hundred seventy-one women with confirmed BC and 222 healthy controls were enrolled in presented study. The level of oxidative DNA damage and the kinetic of their repair were analyzed by the modified alkaline comet assay. The efficiency of BER pathway was evaluated by BER assay. The presence of the 326Cys/Cys genotype and 326Cys allele of OGG1 gene and the 324His/His of MUTYH gene are associated with increased risk of BC development. Moreover, correlation between clinical parameter with selected genes has shown increased risk of BC progression. The survival analysis has shown a significant lower DFS for individuals with the 762Ala/Ala genotype compared to 762Val/Vla carriers and the 762Val/Ala genotype in relation to concomitant chemotherapy and radiotherapy. In subgroup of patients with alone chemotherapy and alone radiotherapy, the 762Val/Val genotype was significantly associated with lower overall survival. Furthermore, we also elevated the level of basal and oxidative DNA damage in a group of patients with BC in relation to healthy controls. We also observed the difference in effectiveness of DNA damage repair. The results of present studies suggested the important role of BER pathway in BC development. © 2015 Wiley Periodicals, Inc.

show abstract

The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients

Cited by 8 publications

References 19 publications

Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population

Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population

A General Sight about Linking PARP-1 and NFKB1 Variations to the Inflammatory Events

The role of base excision repair in pathogenesis of breast cancer in the Polish population

Contact Info

Product

Resources

About