The use of zein in the controlled release of poorly water-soluble drugs

Tran, Phuong Ha-Lien; Duan, Wei; Lee, Beom‐Jin; Tran, Thao T.D.

doi:10.1016/j.ijpharm.2019.06.018

Cited by 63 publications

(40 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As observed from Table 2, there were significant differences between the encapsulation efficiency (EE) values of nanofibers loaded with different EOs concentrations (p < 0.05). Zein has demonstrated to be an appropriate matrix for EO encapsulation due to its amphiphilic nature, as the presence of apolar aminoacids enables hydrophobic interactions with oil constituents, thus exhibiting high encapsulation efficiencies (Tran et al, 2019).…”

Section: Development and Characterization Of Active Fibers Containingmentioning

confidence: 99%

“…The aim of this study was to develop all-natural edible structures through electrospinning containing Laurus nobilis essential oil (LEO) and Rosmarinus officinalis essential oil (REO) for active food packaging applications. The matrix chosen for EOs encapsulation was zein, as it is a biodegradable hydrophobic plant protein that has demonstrated to be an excellent excipient in numerous studies for controlled drug delivery (Tran, Duan, Lee, & Tran, 2019). Moreover, it also has excellent film forming and gas barrier properties, which make it an ideal matrix for edible active food packaging applications (Gaona-Sánchez et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemical-loaded electrospun nanofibers as novel active edible films: Characterization and antibacterial efficiency in cheese slices

et al. 2020

View full text Add to dashboard Cite

The aim of this work was to develop novel active edible electrospun coatings with antimicrobial properties through the encapsulation of essential oils (EOs) from two widely used spices (Laurus nobilis and Rosmarinus officinalis) for inactivating or reducing spoilage and pathogenic microorganisms. Firstly, EOs from dried leaves of both plants were obtained by hydrodistillation and their composition was analysed by Gas Chromatography-Mass Spectrometry (GC-MS). Interestingly, the main component in both extracts, probably as a consequence of the extraction conditions, was 1,8 cineole. Both EOs showed highest antimicrobial activity against Gram-positive than Gram-negative bacteria. Three different concentrations of the 1,8 cineole-rich EOs were incorporated within a zein matrix through electrospinning and solution properties, encapsulation yield, morphological and thermal stability of the edible coatings developed were evaluated. Then, the antibacterial efficiency of EOszein nanofibers (ZNF) films against Listeria monocytogenes, S. aureus and mesophilic bacteria counts (MBC) was compared with their counterparts prepared by casting (ZF) when applied directly on an inoculated side of cheese slices. EO obtained from Laurus nobilis showed higher antibacterial activity than Rosmarinus officinalis. The antibacterial effectiveness of the active films increased through storage time, showing a significant reduction of  2 logarithm units of L. monocytogenes and S. aureus as compared with the control samples, after 28 days at 4 ºC, using the highest content of 1,8 cineole-rich EOs and in films prepared by means of the electrospinning process. Interestingly, the growth of aerobic mesophilic bacteria was also inhibited in cheese slices coated with EOs-loaded ZNF based films.

show abstract

Section: Development and Characterization Of Active Fibers Containingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical-loaded electrospun nanofibers as novel active edible films: Characterization and antibacterial efficiency in cheese slices

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The composition and solubility of zein are prohibitive for its application in food products for human consumption, due to the poor nutritional quality of the protein [ 2 ]. However, the unique properties of this protein have great potential as a starting biomaterial for the development of various structures, including micro/nanoparticles, films, gels, and other formulations able to achieve a sustained release of several drugs as well as improving their therapeutic efficiency and patient compliance [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels

et al. 2020

View full text Add to dashboard Cite

The controlled release of a compound entrapped in a biocompatible formulation is a sought-after goal in modern pharmaceutical technology. Zein is a hydrophobic protein which has several advantageous properties that make it suitable for use as a biocompatible and degradable material under physiological conditions. It is, therefore, proposed for different biomedical and pharmaceutical applications. In particular, due to its gelling properties, it can be used to form a polymeric network able to preserve biomolecules from harsh environments. The current study was designed to investigate the influence of different probes on the rheological properties of gels made up of zein, in order to characterize the systems as a function of the polymer concentration. Four model compounds characterized by different physico-chemical properties were entrapped in zein gels, and different behaviors (viscoelastic or pronounced solid-like characteristics) of the systems were observed. Zein-based gels showed various release profiles of the encapsulated compounds, suggesting that there are different interaction rates between the probes and the polymeric matrix.

show abstract

“…This model explained the amphiphilic and self-assembling nature of zein. Due to its particular physicochemical properties, zein can be converted into film, fiber, and micro-/nanostructures for its utilization in the food and the pharmaceutical industry (Berardi et al, 2018;Corradini et al, 2014;Luecha, Hsiao, Brodsky, Liu, & Kokini, 2011;Paliwal & Palakurthi, 2014;Patel & Velikov, 2014;Tran et al, 2019aTran et al, , 2019b.…”

Section: Propertiesmentioning

confidence: 99%

Development of a nanoparticle delivery system based on zein/polysaccharide complexes

2020

Journal of Food Science

View full text Add to dashboard Cite

Zein, an alcohol-soluble protein in corn, can self-assemble into spherical nanoparticles, which makes it an ideal carrier material for the encapsulation of hydrophobic bioactive molecules. However, zein nanoparticles easily aggregate in water and are sensitive to enzymatic degradation in the digestive system. A strategy to overcome their limitations is the incorporation of polysaccharides as a second polymer layer that provides stability to zein nanoparticles. This review introduces the characteristics of zein as they relate to understanding the formation of zein/polysaccharide nanoparticles. Particular attention is paid to the preparation methods for the zein/polysaccharide nanoparticles, as well as to the morphological observation methods and detection mechanism. Moreover, the properties and applications of zein/polysaccharide nanoparticles are highlighted.

show abstract

The use of zein in the controlled release of poorly water-soluble drugs

Cited by 63 publications

References 129 publications

Phytochemical-loaded electrospun nanofibers as novel active edible films: Characterization and antibacterial efficiency in cheese slices

Phytochemical-loaded electrospun nanofibers as novel active edible films: Characterization and antibacterial efficiency in cheese slices

Influence of Various Model Compounds on the Rheological Properties of Zein-Based Gels

Development of a nanoparticle delivery system based on zein/polysaccharide complexes

Contact Info

Product

Resources

About