The use of tranexamic acid to reduce blood loss during total knee arthroplasty

Hynes, M.; Calder, Peter; Scott, G.

doi:10.1016/s0968-0160(03)00044-9

Cited by 70 publications

(39 citation statements)

References 16 publications

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“…Many clinical studies report tranexamic acid reduces blood loss or transfusion requirements when given on deflation of the tourniquet with a repeated dose postoperatively [6-8, 19, 23, 24, 27, 28, 35, 39, 47, 53, 55]. Some authors recommend two doses of tranexamic acid, once on induction and another dose shortly before release of the tourniquet [27]. Others recommend a dose of 15 mg/kg tranexamic acid at the time of cementing of the prosthesis [39], and yet others recommend a 10-mg/kg bolus dose followed by a dose of 1 mg/kg per hour [3].…”

Section: Discussionmentioning

confidence: 99%

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Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA: A Prospective Randomized Controlled Trial

Charoencholvanich

Siriwattanasakul

2011

Clinical Orthopaedics &Amp; Related Research

138

105

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Background TKA may be associated with considerable blood loss, and transfusion carries substantial risk of immunologic reaction and disease transmission. Blood transfusion also involves additional cost, therefore a reduction in its use is important. Several methods reportedly reduce postoperative blood loss and avoid homologous blood transfusion with traditional TKA approaches, but it is unclear these reductions apply to a minimally invasive technique. Questions/purposes We asked whether tranexamic acid administration could reduce blood loss and blood transfusion requirements after TKA.

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Section: Discussionmentioning

confidence: 99%

“…Several found tranexamic acid decreases blood loss but not transfusion requirements [39,55]. The administration of tranexamic acid also reportedly reduces the decrease in hemoglobin levels after TKA [27]. However, one study found tranexamic acid did not modulate fibrinolytic variables or reduce postoperative bleeding or transfusion requirements after TKA [12].…”

mentioning

confidence: 99%

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA: A Prospective Randomized Controlled Trial

Charoencholvanich

Siriwattanasakul

2011

Clinical Orthopaedics &Amp; Related Research

138

105

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“…In recent years the use of antifibrinolytic medications such as tranexamic acid (TXA) to decrease blood loss and transfusion has slowly gained popularity in orthopaedics [9,19]. Multiple prospective trials involving patients undergoing TJA have demonstrated a reduction in blood loss and transfusion rates with both TXA and e-aminocaproic acid (EACA) [1,2,4,8,17,20,21,25,26,28]. These results have been One of the authors (MWP) certifies that he has or may receive payments or benefits, in any one year, an amount in excess of USD 100,000 from DePuy (Warsaw, IN, USA), MAKO Surgical Corp (Ft Lauderdale, FL, USA), and Stryker Orthopaedics (Mahwah, NJ, USA).…”

Section: Introductionmentioning

confidence: 99%

Preliminary Results Suggest Tranexamic Acid is Safe and Effective in Arthroplasty Patients with Severe Comorbidities

Whiting

Gillette

Duncan

et al. 2014

Clinical Orthopaedics &Amp; Related Research

103

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“…These complications have been estimated as too low. (10,11,12) Despite evidence showing this drug is much useful and has low risk of side effects, it is clear that its use is not part of routine practice in many of the same neurosurgical centers.…”

Section: Discussionmentioning

confidence: 99%

An international based survey on perioperative use of tranexamic acid in neurotrauma

Moscote-Salazar¹,

Agrawal²,

Rubiano³

et al. 2016

Romanian Neurosurgery

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Abstract:Background: Tranexamic acid is used to reduce bleeding, easy to use, affordable and relatively safe. There are few studies on the use of tranexamic acid in trauma and especially in neurosurgery. There is no published study on the trend the use of tranexamic acid in neurotrauma surgery among international doctors. The aim of this study was to evaluate the current practice for use of tranexamic acid during neurotrauma surgery. Materials and Methods: A 11-question electronic survey was sent to 25 practicing physicians worldwide. Basic demographic information and estimated rates of use of tranexamic acid during neurotrauma surgery. Results: Twenty five physicians responded to our survey. Very Few trusts (12%) use tranexamic acid during neurotraumasurgery. Conclusion: Further studies are required to establish guidelines in neurosurgery and neurotrauma, especially. The use of this medicine potentially helps improve patient care with head injury and save lives.

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The use of tranexamic acid to reduce blood loss during total knee arthroplasty

Cited by 70 publications

References 16 publications

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA: A Prospective Randomized Controlled Trial

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA: A Prospective Randomized Controlled Trial

Preliminary Results Suggest Tranexamic Acid is Safe and Effective in Arthroplasty Patients with Severe Comorbidities

An international based survey on perioperative use of tranexamic acid in neurotrauma

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