The Use of Sulfasalazine in Atrophie Blanche

Gupta, Aditya K.; Goldfarb, Michael; Voorhees, John J.

doi:10.1111/j.1365-4362.1990.tb02594.x

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…Recently, a good clinical effect with sulfasalazine has been reported, which is confirmed in eight other patients. 127 , 128 The mechanism of sulfasalazine is unclear. It might have an anti‐inflammatory and a thromboxane inhibiting effect.…”

Section: Therapymentioning

confidence: 99%

Atrophie blanche

et al. 1999

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Section: Therapymentioning

confidence: 99%

Atrophie blanche

et al. 1999

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“…Sulfasalazine. A good clinical outcome with sulfasalazine has been reported (57,58). Gupta et al reported two patients who had not responded to various therapeutic modalities and were given a trial of sulfasalazine 1 g three times daily.…”

Section: Othersmentioning

confidence: 95%

“…A good clinical outcome with sulfasalazine has been reported (57,58). A good clinical outcome with sulfasalazine has been reported (57,58).…”

Section: Othersmentioning

confidence: 98%

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Update of management of connective tissue diseases: livedoid vasculopathy

Gonzalez-Santiago

Davis

2012

Dermatol Ther

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: Livedoid vasculopathy (LV) is characterized by painful purple macules and papules that subsequently ulcerate. The lesions heal over weeks to months resulting in smooth, porcelain‐white, atrophic plaque‐like areas with surrounding telangiectases and hyperpigmentation. The specific cause of LV is still to be determined and it is believed to be multifactorial in nature. Despite numerous available therapeutic agents, there is not a single best efficacious treatment for LV. Most of the available treatment options are based on isolated case reports or case series. In this article, studies on the pathogenesis and therapeutic approaches to LV are reviewed.

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“…3,4 In the literature, several therapeutic approaches have been recommended by different authors to treat these patients. These methods have included fibrinolytic agents (phenformin, ethylestrenol), 4,5 anticoagulants [aspirin, dipyridamole, pentoxifylline, danazol, low-dose heparin, tissue plasminogen activator (t-PA)], [6][7][8][9][10] vasodilators (nicotinic acid, nifedipine, sulfasalazine), 11,12 psoralen plus ultraviolet A and intravenous immunoglobulin (IVIg). 13,14 A combination of aspirin and dipyridamole plus resting and local wound care is currently the most practised treatment.…”

mentioning

confidence: 99%

Intractable livedoid vasculopathy successfully treated with hyperbaric oxygen

Yang¹,

Ho²,

Chan³

et al. 2003

Br J Dermatol

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We describe a new method for treating livedoid vasculopathy. The typical presentation of livedoid vasculopathy includes chronic, recurrent painful ulcers, satellite scar-like atrophy and telangiectasia involving the lower extremities. Histologically, these lesions show areas of ulceration and dermal vessel occlusion without frank inflammatory cell infiltration. There is currently no satisfactory therapy available for this disease. Hyperbaric oxygen (HBO) has recently established itself as one of the most effective methods of treating ischaemic wounds, including diabetic ulcers. We used this therapy in two patients whose lesions were resistant to multiple therapeutic modalities. Not only did their ulcers respond rapidly to the HBO therapy, but the disturbing wound pain also resolved at the same time. To our knowledge, this is the first successful trial of HBO therapy in livedoid vasculopathy. We believe this to be a very promising new therapy for livedoid vasculopathy and to be worth further investigation.

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The Use of Sulfasalazine in Atrophie Blanche

Cited by 12 publications

References 29 publications

Atrophie blanche

Atrophie blanche

Update of management of connective tissue diseases: livedoid vasculopathy

Intractable livedoid vasculopathy successfully treated with hyperbaric oxygen

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