The Use of Snake Venoms as Pharmacological Tools in Studying Nerve Activity

Rosenberg, Philïp

doi:10.1007/978-1-4684-2940-4_5

Cited by 8 publications

(3 citation statements)

References 99 publications

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“…However, at concentrations higher than those needed to inhibit the esterases, eserine appears to also antagonize the action of acetylcholine (Dettbarn & Davis, 1963). At concentrations below 10-3 M eserine has no apparent effect on the axon membrane potential in the squid nerve fibre (Rosenberg, 1971).…”

Section: Effect Of Eserine On the Electrical Potentialsmentioning

confidence: 99%

“…However, a large dose of curare also has slight inhibitory action on cholinesterase (Changeux, 1966). At concentrations below 10-2 M curare has no appreciable effect on the axon membrane potential in the squid intact nerve fibre (Rosenberg, 1971).…”

Section: Effect Of Eserine On the Electrical Potentialsmentioning

confidence: 99%

“…The presence of cholinesterases and the effects of compounds acting on the acetylcholine system have been extensively studied in squid axons (for references, see Nachmansohn, 1959; Ehrenpreis, 1964;Rosenberg, 1971), specially after Nachmansohn proposed the acetylcholine theory of bioelectricity to account for the mechanism responsible for axonal conduction. Although the intervention of acetylcholine in the conducting mechanism has been ruled out (Ritchie & Armett, 1963), the question remains of what role, if any, cholinesterases play in the functioning of the nerve fibre.…”

Section: Introductionmentioning

confidence: 99%

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Effects of tubocurarine and eserine on the axon‐Schwann cell relationship in the squid nerve fibre

Villegas¹

1973

The Journal of Physiology

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SUMMARYThe effects of eserine and D-tubocurarine on the axon and Schwann cell membrane potentials have been studied in the giant nerve fibre of the squid.1. The addition of eserine at concentrations of up to 10-4M to the external sea-water medium has no appreciable effects on either the Schwann cell electrical potential of unstimulated nerve fibres or on the resting and action potentials of the axon.2. However, eserine at a concentration of 10-9 M prolongs the longlasting Schwann cell hyperpolarizations which follow the conduction of impulse trains by the axon.3. Higher concentrations of eserine (10-7, 10-4M) decrease and block the long-lasting effects of nerve impulse train conduction.4. D-tubocurarine at concentrations of up to 10-5 M has no appreciable effect on the resting and action potentials of the axon.5. However, D-tubocurarine at a concentration of 10-9 M blocks completely the hyperpolarizing effects of nerve impulse trains on the Schwann cell electrical potential.6. In addition to its blocking action, D-tubocurarine induces transient hyperpolarizations in the Schwann cells of unstimulated nerve fibres both in intact fibres and in slitted preparations.7. These findings suggest that a cholinergic system, which may be located at the axon-Schwann cell boundary, is involved in the genesis of the long-lasting Schwann cell hyperpolarization caused by the conduction of nerve impulse trains by the axon. 7-2

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Section: Effect Of Eserine On the Electrical Potentialsmentioning

confidence: 99%

Section: Effect Of Eserine On the Electrical Potentialsmentioning

confidence: 99%