The Squid Giant Axon: Methods and Applications

Rosenberg, Philïp

doi:10.1007/978-1-4684-3806-2_1

Cited by 6 publications

(1 citation statement)

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“…3) and with suitable modifications even for chemically activated channels [35], they provide a good starting point for the study of anaesthetic interactions with ion channels. The actions of hundreds of agents, including anaesthetics, have been evaluated in pharmacological studies [50,55,591. The suppression of sodium channels by gaseous and volatile anaesthetics follows the Meyer-Overton correlation [63].…”

Section: Sodium Channel As a Model System For Ion Channelsmentioning

confidence: 99%

Differential Effects of Gaseous and Volatile Anaesthetics on Sodium and Potassium Channels

Urban

1993

British Journal of Anaesthesia

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After 150 years of clinical anaesthesia, the molecular events that lead to anaesthesia have not been determined. This is not because of a lack of ideas [16-19, 56, 571. However, most striking to the observer is the paucity of long-term and systematic studies. The present review describes results from such a study. The long-term goals were: first, to understand how anaesthetics affect membrane protein function and second, to determine if clinical and molecular actions of anaesthetics rnay be correlated. Definition of anaesthesia und anaesthetic Before the mechanisms of anaesthetics are discussed, the term " anaesthesia" should be defined in practical terms [64] : " Anaesthesia describes the condition of a patient corresponding to the one produced by diethyl-ether which permits surgery to be performed without the patient moving, reacting to pain, or remembering the surgical intervention after recovery from anaesthesia." Strictly speaking, only a substance that has all these qualities rnay be called a general anaesthetic. However, clinical practice is such that almost all general anaesthetics are given in combination with other agents at concentrations where, by themselves, they rnay not produce anaesthesia. Therefore, the term general anaesthetic is used for substances that, at sufficiently large concentrations, could produce anaesthesia, although for a variety of reasons these large concentrations are not used in common clinical practice. While this definition extends across the range of general anaesthetics, basic scientists have broadened the definition further : they include all substances that in animal experiments produce "anaesthesia-like" states, as determined by the absence of certain reflexes (e.g. in response to pain, in response to posture changes, etc), and in addition, anaesthetic-like compounds are included also. These substances rnay not have been tested in whole animal experiments, but rnay act similar to general

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Section: Sodium Channel As a Model System For Ion Channelsmentioning

confidence: 99%