The use of platelet rich plasma in the treatment of immature tooth with periapical lesion: a case report

Polat, Günseli Güven; Yıldırım, Ceren; Akgün, Özlem Martı; Altun, Ceyhan; Dinçer, Didem; Özkan, Cansel Köse

doi:10.5395/rde.2014.39.3.230

Cited by 18 publications

(5 citation statements)

References 29 publications

(49 reference statements)

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“…In several reports in REPs, evoked bleeding technique has been used to produce a blood clot scaffold [8], which promotes proliferation and differentiation of progenitor/stem cells [1]. Recent studies have used alternative scaffolds such as platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) in regenerative endodontic treatment [151617]. It has been stated that PRF is an ideal purely autologous scaffold for regeneration, which constitutes key growth factors for promoting the proliferation and differentiation of progenitor/stem cells [318].…”

Section: Introductionmentioning

confidence: 99%

Coronal tooth discoloration induced by regenerative endodontic treatment using different scaffolds and intracanal coronal barriers: a 6-month ex vivo study

et al. 2019

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Objective The aim of this study was to evaluate discoloration of teeth undergoing regenerative endodontic procedures (REPs) using blood clot or platelet-rich fibrin (PRF) as the scaffolds and different calcium silicate-based materials as the intracanal coronal barriers in an ex vivo model. Materials and Methods Forty-eight bovine incisors were prepared and disinfected using 1 mg/mL double antibiotic paste (DAP). The specimens were then randomly divided into 2 groups ( n = 24) according to the scaffolds (blood or PRF). After placement of scaffolds each group was divided into 2 subgroups ( n = 12) according to the intracanal coronal barriers (ProRoot MTA or Biodentine). The pulp chamber walls were sealed with dentin bonding agent before placement of DAP and before placement of scaffolds. The color changes (∆E) were measured at different steps. The data were analyzed using 2-way analysis of variance. Results Coronal discoloration induced by DAP was not clinically perceptible (ΔE ≤ 3.3). Regarding the type of the scaffold, coronal discoloration was significantly higher in blood groups compared with PRF groups at the end of REP and after 1 month ( p < 0.05). However, no significant difference was found between PRF and blood clot after 6 months ( p > 0.05). Considering the type of intracanal coronal barrier, no significant difference existed between ProRoot MTA and Biodentine ( p > 0.05). Conclusions With sealing the dentinal tubules of pulp chamber with a dentin bonding agent and application of DAP as an intracanal medicament, coronal color change of the teeth following the use of PRF and blood sealed with either ProRoot MTA or Biodentine was not different at 6-month follow-up.

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Section: Introductionmentioning

confidence: 99%

Coronal tooth discoloration induced by regenerative endodontic treatment using different scaffolds and intracanal coronal barriers: a 6-month ex vivo study

et al. 2019

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“…Mineral trioxide aggregate was placed onto the root canal orifices after PRP application to obtain a tight coronal seal as it is hydrophilic and needs moisture to set. Also, MTA by itself provides signalling molecules for the growth of the stem cells (Güven Polat et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of postoperative pain and healing following regenerative endodontics using platelet‐rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic periapical periodontitis. A randomized clinical trial

Ahmed

Ghoneim

2023

Int Endodontic J

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Aim:To evaluate the post-operative pain and the healing of necrotic mature permanent mandibular molar teeth with peri-apical periodontitis after conventional endodontic treatment versus after platelet-rich plasma (PRP) revascularization. Methodology:The protocol of this randomized clinical trial was registered at www. clini caltr ials.gov with identification number NCT 03350841. Twenty-eight patients were included in the study after confirming the diagnosis clinically and radiographically. In the first visit, mandibular molar teeth of both groups were mechanically prepared. Double antibiotic paste was prepared and injected then the cavity that was sealed with glass ionomer. At the second visit, the patients were randomized either to control group where standard endodontic treatment was completed by lateral condensation technique or assigned to intervention group where PRP revascularization technique. The degree of spontaneous pain was assessed using numerical rating scale (NRS) pre-operatively, then post-operatively after 6, 12 h and daily for 5 days.Patients were given a placebo to be administrated in case of pain. An analgesic (ibuprofen 400mg) was prescribed in case of persistent pain. Clinical and radiographic healing was assessed after 6 and 12 months. All demographic, baseline and outcome data were collected and statistically analysed.Results: Regarding the post revascularization/obturation pain, there was no statistically significant difference between severity of pain in the two groups at all time intervals except after 12 h, revascularization group showed statistically significantly higher prevalence of no pain than endodontic treatment group. Regarding the healing; the periapical lesions decrease in size significantly from the pre-operative lesion size in both groups without significant difference between the both groups. Conclusion:Within the limitation of this study, PRP revascularization could be an alternative treatment to root canal treatment but further randomized clinical trials with standardized techniques and long follow up periods are recommended for more reliable results.

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“…), tetracycline (Guven Polat et al . ) or cefaclor (Thibodeau & Trope , Thibodeau , Kim et al . , Amit et al .…”

Section: Discussionmentioning

confidence: 99%

A scoping review of root canal revascularization: relevant aspects for clinical success and tissue formation

et al. 2016

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The aim of this scoping study was to evaluate the survival rate and nature of tissue formed inside root canals of human immature permanent teeth with necrotic pulps (NIPT) under root canal revascularization (RCR). The search was performed in SciVerse Scopus®, PubMed/MEDLINE, Web of Science®, BIREME and in the grey literature up to November 2015. The keywords were selected using MeSH terms and DECs. Two independent reviewers scrutinized the records obtained considering specific inclusion criteria. The included studies were evaluated in accordance with a modified Arksey and O' Malley's framework. From 375 studies that were evaluated, 75 were included. A total of 367 NIPT were submitted to RCR, from which only 21 needed further endodontic treatment. The weighted mean follow-up time was 17.6 months. The data were derived mainly from case reports (69%) or small case series (15%). NaOCl [0.5-6%] was applied as the disinfecting solution in almost all studies. Triple antibiotic paste was as effective as Ca(OH) as on intracanal medicament. De novo tissue was cementum and poorly mineralized bone positive to bone sialoprotein (BSP) but negative to dentine sialoprotein (DSP). Failures were associated mainly with reinfection of the root canal. The majority of included studies reported a significant increase in both root length and width. However, as most of these data came from case reports, they must be interpreted with care, as most were focused on treatment successes (not failures). Therefore, well-designed randomized controlled trials comparing RCR with available apexification treatments are needed to address this gap in the literature.

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The use of platelet rich plasma in the treatment of immature tooth with periapical lesion: a case report

Cited by 18 publications

References 29 publications

Coronal tooth discoloration induced by regenerative endodontic treatment using different scaffolds and intracanal coronal barriers: a 6-month ex vivo study

Coronal tooth discoloration induced by regenerative endodontic treatment using different scaffolds and intracanal coronal barriers: a 6-month ex vivo study

Evaluation of postoperative pain and healing following regenerative endodontics using platelet‐rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic periapical periodontitis. A randomized clinical trial

A scoping review of root canal revascularization: relevant aspects for clinical success and tissue formation

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