The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia

Rahmat, Leena T.; Damon, Lloyd E.

doi:10.1155/2018/7267920

Cited by 9 publications

(5 citation statements)

References 6 publications

(19 reference statements)

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“…This foundational step is integral to determining optimal dosages and duration of administration, thereby establishing a solid groundwork for subsequent human trials [ 27 ]. In the current study, the dosages chosen were guided by existing human usage patterns for C. papaya leaf extract, which has previously been employed as a dietary supplement [ 37 ]. In humans, the daily dosage for this extract ranges from 1 to 50 g, which translates into a daily intake of 17 to 833 mg for an average 60 kg male [ 5 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Safety of Oral Carica papaya L. Leaf 10% Ethanolic Extract for Acute and Chronic Toxicity Tests in Sprague Dawley Rats

Taychaworaditsakul,

Saenjum,

Lumjuan

et al. 2024

Toxics

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Carica papaya L. leaves, traditionally utilized in dietary supplements and pharmaceuticals, exhibit a broad spectrum of potentially therapeutic properties, including anti-inflammatory, antimalarial, and wound healing properties. This study examined the acute and chronic toxicity of 10% ethanolic-extracted C. papaya leaf in Sprague Dawley rats. The acute toxicity assessment was a single oral dose of 5000 mg/kg body weight, while the chronic toxicity assessment included daily oral doses of 100, 400, 1000, and 5000 mg/kg over 180 days. Systematic monitoring covered a range of physiological and behavioral parameters, including body and organ weights. End-point evaluations encompassed hematological and biochemical analyses, along with gross and histopathological examinations of internal organs. Findings revealed no acute toxicity in the C. papaya leaf extract group, although a significant decrease in uterine weight was observed without accompanying histopathology abnormalities. In the chronic toxicity assessment, no statistically significant differences between the control and the C. papaya leaf extract groups were detected across multiple measures, including behavioral, physiological, and hematological indices. Importantly, histopathological examination corroborated the absence of any tissue abnormalities. The study results indicate that C. papaya leaf extract exhibited no adverse effects on the rats during the 180-day oral administration period, affirming its potential safety for prolonged usage.

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Section: Discussionmentioning

confidence: 99%

Safety of Oral Carica papaya L. Leaf 10% Ethanolic Extract for Acute and Chronic Toxicity Tests in Sprague Dawley Rats

Taychaworaditsakul,

Saenjum,

Lumjuan

et al. 2024

Toxics

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“…Pharmacological studies have shown that dandelions have antimicrobial, antiviral, anticancer, antioxidant, anti-inflammatory, and anti-allergic effects ( He et al, 2011 ; Ovadje et al, 2011 ; Ovadje et al, 2012 ; Qian et al, 2014 ; Wang, 2014 ; Ma et al, 2015 ; Ovadje et al, 2016 ; Jedrejek et al, 2017 ; Rehman et al, 2017 ; Ding and Wen, 2018 ; Liu et al, 2018 ; Rahmat and Damon, 2018 ). Extract from Dandelion: ethyl acetate extract (EAED).…”

Section: The Effect Of Traditional Chinese Therapy On Cholinergic Ant...mentioning

confidence: 99%

The potential for traditional Chinese therapy in treating sleep disorders caused by COVID-19 through the cholinergic anti-inflammatory pathway

Xie

Zhang

et al. 2022

Front. Pharmacol.

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Since the outbreak of Coronavirus disease (COVID-19) in 2019, it has spread rapidly across the globe. Sleep disorders caused by COVID-19 have become a major concern for COVID-19 patients and recovered patients. So far, there’s no effective therapy on this. Traditional Chinese therapy (TCT) has a great effect on sleep disorders, with rare side effects and no obvious withdrawal symptoms. The cholinergic anti-inflammatory pathway, a neuroregulatory pathway in the central nervous system that uses cholinergic neurons and neurotransmitters to suppress inflammatory responses, has been reported to be associated with sleep disorders and psychiatric symptoms. Many studies have shown that TCT activates the cholinergic anti-inflammatory pathway (CAP), inhibits inflammation, and relieves associated symptoms. Therefore, we believe that TCT may be a potential therapeutic strategy to alleviate sleep disorders induced by COVID-19 through CAP. In this review, we analyzed the relationship between cytokine storm induced by Coronavirus and sleep disorders, explained the influence of CAP on sleep disorders, discussed the TCT’s effect on CAP, and summarized the treatment effect of TCT on sleep disorders. Based on these practical researches and theoretical basis, we propose potential strategies to effectively improve the sleep disorders caused by COVID-19.

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“…In addition, it has many pharmacological effects. Modern pharmacological studies show that the properties of dandelion include antibacterial [ 9 , 10 ], antiviral [ 11 ], anticancer [ 12 – 16 ], antioxidant [ 17 ], anti-inflammatory [ 18 – 20 ], and antiallergic functions. In terms of the alleviation of airway inflammation, a distinctive feature of asthma, it has been reported that the organic acid components of TMHM can improve lipopolysaccharide-induced histopathological damage to tracheal tissues [ 21 ] and reduce lipopolysaccharide-induced inflammation in normal human bronchial epithelial cells [ 22 ], which could be beneficial for the treatment of acute tracheobronchitis.…”

Section: Introductionmentioning

confidence: 99%

Dandelion extract relaxes mouse airway smooth muscle by blocking VDLCC and NSCC channels

et al. 2020

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Background Asthma is one of the main intractable diseases recognized by the international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating the development of novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated the relaxant effects and underlying mechanism of an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Methods The effects of EAED on agonist-induced precontraction in mouse airway smooth muscle were evaluated with force measurement. Mouse lung slices were used to study the effects of EAED on bronchial smooth muscle. The intracellular Ca2+ concentration was measured using a calcium imaging system. L-type voltage-dependent calcium channel (VDLCC) and non-selective cationic channel (NSCC) currents were measured by patch-clamp. The lung functions of healthy and asthmatic mouse groups were assessed via the forced oscillation technique. Results EAED inhibits acetylcholine-induced sustained contractions of whole airway smooth muscle by inhibiting VDLCCs, NSCCs, and some unknown channels, reduces the agonist-induced increase in the cytosolic free Ca2+ concentration in airway smooth muscle cells, blocks VDLCC and NSCC currents, and relieves the respiratory resistance of healthy and asthmatic mice. Conclusions EAED may have potential beneficial effects on mitigating asthma attacks.

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The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia

Cited by 9 publications

References 6 publications

Safety of Oral Carica papaya L. Leaf 10% Ethanolic Extract for Acute and Chronic Toxicity Tests in Sprague Dawley Rats

Safety of Oral Carica papaya L. Leaf 10% Ethanolic Extract for Acute and Chronic Toxicity Tests in Sprague Dawley Rats

The potential for traditional Chinese therapy in treating sleep disorders caused by COVID-19 through the cholinergic anti-inflammatory pathway

Dandelion extract relaxes mouse airway smooth muscle by blocking VDLCC and NSCC channels

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