The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia

Tukur, Jamilu

doi:10.4103/1596-3519.56232

Cited by 47 publications

(54 citation statements)

References 17 publications

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“…Stress-induced respiratory pattern changes have been reported in asthma [136], pulmonary microembolism [137], pulmonary inflammation [137], septicemia [138,139], myocardial infarction [140], brainstem infarction [141], preeclampsia [142,143], eclampsia [135], and anaphylactic shock [144]. Emotions and stress are known to change the respiratory pattern [136,145,146].…”

Section: Stress Induced Breathing Patterns Following Vaccinationmentioning

confidence: 99%

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Davidson¹,

Seneff²

2012

Entropy

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Abstract:In reviewing the literature pertaining to interfacial water, colloidal stability, and cell membrane function, we are led to propose that a cascade of events that begins with acute exogenous surfactant-induced interfacial water stress can explain the etiology of sudden death syndrome (SDS), as well as many other diseases associated with modern times. A systemic lowering of serum zeta potential mediated by exogenous cationic surfactant administration is the common underlying pathophysiology. The cascade leads to subsequent inflammation, serum sickness, thrombohemorrhagic phenomena, colloidal instability, and ultimately even death. We propose that a sufficient precondition for sudden death is lowered bioavailability of certain endogenous sterol sulfates, sulfated glycolipids, and sulfated glycosaminoglycans, which are essential in maintaining biological equipose, energy metabolism, membrane function, and thermodynamic stability in living organisms. Our literature review provides the basis for the presentation of a novel hypothesis as to the origin of endogenous bio-sulfates which involves energy transduction from sunlight. Our hypothesis is amply supported by a growing body of data showing that parenteral administration of substances that lower serum zeta potential results in kosmotropic cationic and/or chaotropic anionic interfacial water stress, and the resulting cascade.Keywords: inflammation; serum sickness; colloidal instability; interfacial water stress; bio-sulfates; Shwartzman phenomena; sudden death syndrome Glossary of TermsAnaphylaxis a severe, rapidly progressing, life-threatening, generalized allergic reaction. Biological equipoise a stable, non-equilibrium, dissipative system synonymous with life. Cholesterol sulfate (Ch-S)quantitatively the most important known sterol sulfate in human plasma where it regulates the activity of the serine proteases, in cell membranes where it has a stabilizing role, and in platelet membranes where it supports platelet adhesion. Coherence domain (CD)a water CD is a collection of liquid water molecules which oscillate in unison in tune with a self-trapped electromagnetic field at a well-defined frequency. The coherent oscillations produce an ensemble of quasi-free electrons, able to collect noise energy from the environment and transform it into high-grade coherent energy in the form of electron vortices. This high-grade energy may then activate biomolecules resonating with the water CD. Colloidal instabilitya property attributed to a colloidal suspension that develops when stabilizing repulsive steric and electrostatic forces between colliding particles are insufficient to prevent their natural tendency to aggregate into masses large enough to precipitate.Colloidal suspension a colloid that has a continuous liquid phase in which a solid is suspended in a liquid, e.g., our flowing blood. Exclusion zone (EZ)a glass-like, gel phase consisting of water CDs resonating in-phase, adjacent to hydrophilic surfaces, several hundred micrometers wide which excludes colloi...

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Section: Stress Induced Breathing Patterns Following Vaccinationmentioning

confidence: 99%

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Davidson¹,

Seneff²

2012

Entropy

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“…It is estimated that every year eclampsia is associated with 50,000 deaths worldwide. 1 Management of pre-eclampsia and eclampsia continues to pose a challenge. The only definitive cure is termination of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Comparison of low dose Dhaka regimen of magnesium sulphate with standard pritchard regimen in eclampsia

Sharma¹,

Gupta²,

Nigam

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…It was recommended by the WHO as the most effective, safe and cheapest drug to treat Severe preeclampsia and eclampsia [1,4]. Several studies show that it is the best cure to prevent patients from re-suffering from eclampsia crisis, as it is more effective than Phenytoin [(5.7%) vs.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies show that it is the best cure to prevent patients from re-suffering from eclampsia crisis, as it is more effective than Phenytoin [(5.7%) vs. The exact mode of action of magnesium sulphate in pre-eclampsia remains to be elucidated, but it has been proved that it prevent calcium from entering into the cell [4,5].…”

Section: Introductionmentioning

confidence: 99%

Use of Magnesium Sulphate in the Management of Severe Preeclampsia at the Centre University Hospital of Mother and Child (CHU-MEL) Cotonou Benin

Ja¹,

Mshs²,

Aboubakar³

et al. 2017

Gynecol Obstet

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Objectives: To evaluate professionals practices and the contribution of magnesium sulphate in a better medical care for persons with severe preeclampsia at CHU-MEL. Materials and Method:We conducted a retrospective and cross-sectional study with the aim come up with a descriptive and analytical paper. Our study was conducted from January 15th, 2015 to July 15th, 2016, i.e. during eighteen (18) months. The sampling was exhaustive. The population was made of all patients admitted for severe preeclampsia with or without complications. Confidentiality requirements were met and informed consent obtained from all subjects. For the analytical study, the chi-square test was used and the difference was statistically significant with a p-value inferior than 0.05. Results:The prevalence of preeclampsia during the study period was 7.70% (447/5805 deliveries). Out of the 312 files that we were able to find and exploit, 272 revealed that patients were administrated a dose of magnesium sulphate, at a frequency estimated at 87.18%. Irregularities were noted in the protocol implementation: the maintenance dose was administered in 30% of cases, as a slow infusion (66.33%), for less than 24 hours in 37.24% of cases, and under supervision only in 22.62% of cases. Primary and secondary prevention of eclampsia was achieved in 98.5% and 80% of cases, respectively. Respecting the duration of treatment significantly reduces the onset and recurrence of seizures (p=0.003 and p=0.004). Decreased reflexes and respiratory distress were noted in 34.78% and in 8.7% of cases respectively. The maternal lethality rate was 1.34% and the stillbirth rate was 11.40%. Conclusion:Magnesium sulphate intake is undeniable in dealing with severe preeclampsia, but this solution/ drug is misused at the CHU-MEL. Appropriate solutions must therefore be taken in the execution and monitoring of the protocol.

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The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia

Cited by 47 publications

References 17 publications

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Comparison of low dose Dhaka regimen of magnesium sulphate with standard pritchard regimen in eclampsia

Use of Magnesium Sulphate in the Management of Severe Preeclampsia at the Centre University Hospital of Mother and Child (CHU-MEL) Cotonou Benin

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