Comparison of low dose Dhaka regimen of magnesium sulphate with standard pritchard regimen in eclampsia

Sharma, Anshu; Gupta, Kamali; Nigam, Aruna; Pathania, Kushla

doi:10.18203/2320-1770.ijrcog20163870

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…In our study, we observed the impending signs of magnesium sulfate toxicity as loss of deep tendon reflex in16.13% and 15.38% cases of eclampsia and severe preeclampsia respectively which were very significant (P-values 0.04 and 0.01 respectively) majority of cases were in group I (Pritchard), oliguria (<30ml/hour) in 9.68% and 12.82% cases of both eclampsia and severe preeclampsia respectively (P-values were significant 0.031 and 0.05 respectively) most of cases were found in group I (Pritchard). The local site complication i.e gluteal abcess was only found in patients who received Pritchard regimen which was in concordance with the study conducted by Vaibhav Kanti [13] and Anshu Sharma [17] , this complication becomes important as it requires daily dressing and some time debridment and therefore prolongs the hospital stay thereby increasing the maternal morbidity. In a study conducted by ChissellS [18] , who found that magnesium sulfate toxicity was in 12.5% cases of intravenous group and none in intramuscular group, contrast to our findings.…”

Section: Resultssupporting

confidence: 84%

Is low dose magnesium sulfate regimen a better option for treatment of hypertensive disorders of pregnancy: Our experience at tertiary care centre

Agarwal¹,

Gupta²,

Pandey³

et al. 2020

Int. J. Clin. Obstet. Gynaecol.

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Introduction: Hypertensive disorders of pregnancy is one of the leading causes of fetomaternal mortality and affecting 10% of all pregnancies. Materials and Methods: A prospective interventional study was conducted on 140 patients from January 2017 to January 2019 and comparision was made among the three different magnesium sulfate regimens.78 patients with severe preeclampsia and 62 patients with eclampsia were randomly allocated in 3 groups and were followed up to delivery to evaluate the fetomaternal outcome. Then the results were compared and analysed. Results: Statistically higher incidence of signs of impending toxicity such as loss of patellar reflex, oliguria, respiratory rate depression were more in group 1(Pritchard) as compared to other groups. There were no significant differences in other measures of feto-maternal complications. Conclusion:As compared to Pritchard, Zuspan and Dhaka (Low dose regimens) have similar efficacy in controlling and prevention of convulsions & potentially have less side effects.

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Section: Resultssupporting

confidence: 84%

Is low dose magnesium sulfate regimen a better option for treatment of hypertensive disorders of pregnancy: Our experience at tertiary care centre

Agarwal¹,

Gupta²,

Pandey³

et al. 2020

Int. J. Clin. Obstet. Gynaecol.

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“…7 Another study by Anshu, et al had most of the subjects belonging to 18-25 years of age(64.5%). 8 The study by Surinder Kumar et al had 51.21% cases from 21-25 years of age. 9 Maternal age of less than 20 years is the strongest risk factor (Sahu Lathika et al).…”

Section: Resultsmentioning

confidence: 99%

A comparative study of maternal outcome between low dose and standard dose magnesium sulphate as regimen for the treatment of eclampsia in a tertiary centre

Mohanty

Behuria

Nayak³

2016

Int J Reprod Contracept Obstet Gynecol

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“…Sokoto (ultra-short) regimen by Ekele et al . [ 16 ] and low-dose Dhaka[ 17 ] regimen of magnesium sulfate protocols are quick examples and alternatives to standard-dose therapy in eclamptic. Whether these noble short courses can be reduced while maintaining the efficacy profile of MgSO 4 is a major drive for this study.…”

Section: Introductionmentioning

confidence: 99%

“…These attempts are furthermore empowered by randomized controlled trials which showed that seizures can be effectively controlled in cases of eclampsia by giving only the loading dose in different continents. [ 17 18 ] Only a few randomized studies have elucidated the efficacy of lower doses of MgSO 4 as seizure prophylaxis in severe preeclampsia. [ 17 19 20 21 ] It appears, therefore, that the search for the lowest effective dose to prevent convulsion remains an area of continuing research.…”

Section: Introductionmentioning

confidence: 99%

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A randomized controlled trial of loading dose alone versus pritchard regimen of magnesium sulphate, for seizure prophylaxis in severe preeclampsia

Obanimoh¹,

Isah²,

Abdullahi³

et al. 2023

Ann Afr Med

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Background: Preeclampsia poses a significant risk of maternal and neonatal morbidity and mortality. Magnesium sulfate superiority for seizure prophylaxis in severe preeclampsia has been proven globally. However, the search for the lowest effective dose is an area of continuing research. Aim: The aim of this study was to compare the effectiveness of loading dose with the Pritchard regimen of magnesium sulfate for seizure prophylaxis in severe preeclampsia. Materials and Methods: A total of 138 eligible women after 28-week gestation with severe preeclampsia were randomized to either receiving a single loading dose of MgSO 4 (study arm: n = 69) or Pritchard regimen of MgSO 4 (control: n = 69). The effectiveness was assessed by the development of seizure. The results obtained were analyzed using SPSS version 21. Categorical variables were analyzed using the Chi-square test and normally distributed continuous variables were analyzed with t -test and Fisher's exact test. P < 0.05 was considered statistical significance. Results: There were no significant differences between those who received only the loading dose when compared with those who had Pritchard regimen other than a single recorded convulsion among the control group ( P = 0.316). Similarly, except for the duration of hospital stay which was significantly longer in the Pritchard group ( P = 0.019), both the arms of the study shared similar maternal and fetal outcomes. Conclusion: This study suggests the effectiveness of just the loading dose of magnesium sulfate when compared with the standardized Pritchard regimen in the prevention of seizure among women with severe preeclampsia. The study also demonstrated safety and similarity in fetal-maternal outcome. The loading dose only had an added advantage of shorter duration of hospital stay.

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Comparison of low dose Dhaka regimen of magnesium sulphate with standard pritchard regimen in eclampsia

Cited by 5 publications

References 7 publications

Is low dose magnesium sulfate regimen a better option for treatment of hypertensive disorders of pregnancy: Our experience at tertiary care centre

Is low dose magnesium sulfate regimen a better option for treatment of hypertensive disorders of pregnancy: Our experience at tertiary care centre

A comparative study of maternal outcome between low dose and standard dose magnesium sulphate as regimen for the treatment of eclampsia in a tertiary centre

A randomized controlled trial of loading dose alone versus pritchard regimen of magnesium sulphate, for seizure prophylaxis in severe preeclampsia

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