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Background: Extra-hepatic portal vein obstruction (EHPVO) due to portal vein thrombosis is an important cause of portal hypertension in several region including India. The cause of thrombosis in these patients remains unclear. Objective of the study was to study the demographic features, etiology, clinical, laboratory findings with special reference to thrombophilic factors like protein C, protein S and antithrombin III deficiency in children with EHPVO.Methods: The prospective analysis of 62 patients of EHPVO (<14 years of age) was done in the Department of Hepatology, SCB medical College, Cuttack. After detailed history, clinical examination, Ultrasound abdomen /color Doppler and Upper GI endoscopy, the subjects were analyzed for any deficiency of thrombophilic factors like protein C, protein S and antithrombin III.Results: A total of 62 patients (37 Male, 25 Female) with mean age of 8.3+3.1 years were studied. Growth retardation was present in the form of wasting (alone) 20.9%, stunting (alone) 25.8% and both wasting and stunting was found in 9.8% cases. History of neonatal, umbilical sepsis and umbilical vein catheterization was found in 15.9% and 10.2% of cases respectively. Haemorrhage from oesophageal varices was prevalent symptoms in 85.9% patients. Splenomegaly was found in 91.9% patients and ascites in 9.4% patients. 47 patients studied for protein C, S and antithromibin III. 14 patients were found to have thrombophilia: protein C deficiency in 9, protein S deficiency in 8, Antithrombin III deficiency in 6.Conclusions: The etiology of EHPVO in the majority of patients remain still unclear. It is commonly associated impaired somatic growth. The risk of EHPVO increases in the presence of thrombophilia, resulting from deficiency of naturally occurring anticoagulant proteins like Protein C, Protein S and Antithrombin III.

Hepatitis is a highly infectious disease caused by a number of viruses. A study was undertaken in a ward of Cuttack City, where suddenly a number of cases of Jaundice reported. A team from the departments of Community Medicine visited the ward and collected the data by door to door survey. A total of 281 houses were surveyed and data was obtained. There were a total number of 55 jaundice cases. The cases reported with symptoms of fever, anorexia, yellow sclera and yellow urine. 64.3% of cases used Municipality source of water. 7.3% used the water for drinking purpose after boiling and filtration. 28% of houses did not have sanitary latrine, 85.5% from all the jaundice cases used the water for drinking purposes. The young adults were mostly affected. The cause of jaundice could be due to contamination of water supply by Municipality because of leakage and the causative agent was Hepatitis E Virus.

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Introduction: Pregnancy-related liver diseases are significant medical conditions with a poor prognosis that present a challenge to both obstetricians and hepatologists. Around 3% of pregnancies worldwide and 3-5% of pregnancies in India are impacted by it. Numerous symptoms, including a yellowish discoloration of the sclera, black urine, anorexia, nausea, vomiting, and stomach pain, can be present. Hyperemesis gravidarum, preeclampsia, eclampsia with liver dysfunction, hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome, intrahepatic cholestasis of pregnancy (IHCP), and acute fatty liver of pregnancy are among the specific liver illnesses associated with pregnancy. Methods: This prospective observational study was carried out at the SCB Medical College and Hospital in Cuttack, Department of Obstetrics and Gynecology. On the basis of the inclusion criteria, 85 prenatal cases were prospectively investigated. Those who underwent a thorough history and examination, clinical symptoms suggestive of liver disorders, all available LFTs, including LDH, as well as some more conclusive tests to help identify the underlying cause, were then monitored up until delivery in terms of the outcome for the maternal and the foetus. Results: There were 0.86% cases of hepatic problems during pregnancy. In the study group, 76.5% of cases appeared in the third trimester of pregnancy, 72.9% of cases were primigravida, and 90.59% of cases were between 20 and 30 years old. 76.4% of the participants in this study had a liver condition unique to pregnancy, of which 32.9% had pre-eclampsia, 11.7% had eclampsia, and 11.7% had HELLP syndrome. 16.4% had ICP, 2.3% had AFLP, and 1.1% had hyperemesis gravidarum. Morbidity was 34.12% and maternal mortality was 10.58%. Preterm 21.1%, stillbirth 38.82%, live birth 61%, and IUGR 24.7%. In 28.57% of cases, NICU admission is necessary. Conclusion: Poor outcomes for the maternal and the foetus are linked to abnormal liver function during pregnancy. Many pregnant women and their unborn children can be saved by routine prenatal screenings, liver problem diagnosis, and treatment.