The Use of Coralline Hydroxyapatite With Bone Marrow, Autogenous Bone Graft, or Osteoinductive Bone Protein Extract for Posterolateral Lumbar Spine Fusion

Boden, Scott D.; Martin, George J.; Morone, Michael A.; Ugbo, John L.; Titus, Louisa; Hutton, William

doi:10.1097/00007632-199902150-00003

Cited by 167 publications

(92 citation statements)

References 34 publications

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“…52 In single-level posterolateral lumbar arthrodesis performed in 48 adult New Zealand White rabbits, the combination of BMPs and coralline hydroxyapatite resulted in 100% fusion rates. 53 This was in contrast to the groups receiving coralline hydroxyapatite with bone marrow (0% union rates) and the coralline hydroxyapatite with autogenous iliac crest bone (50% union rates). The authors concluded that when coralline grafts were combined with autogenous iliac crest bone graft served as a graft extender yielding results comparable to those obtained with autograft alone.…”

Section: Animal Studiesmentioning

confidence: 82%

“…The authors concluded that when coralline grafts were combined with autogenous iliac crest bone graft served as a graft extender yielding results comparable to those obtained with autograft alone. 53 In addition to BMPs other molecules have been investigated. In a comparative study of Insulin growth factor-1 (IGF-1) and BMP-2, IGF-1 was more potent inducer of bone regeneration when loaded on a coralline hydroxyapatite scaffold for the treatment of proximal tibial defects.…”

Section: Animal Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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Xenogeneic bone graft materials are an alternative to autologous bone grafting. Among such implants, coralline-derived bone grafts substitutes have a long track record as safe, biocompatible and osteoconductive graft materials. In this review, we present the available literature surrounding their use with special focus on the commercially available graft materials. Corals thanks to their chemical and structural characteristics similar to those of the human cancellous bone have shown great potential but clinical data presented to date is ambiguous with both positive and negative outcomes reported.Correct formulation and design of the graft to ensure adequate osteo-activity and resorption appears intrinsic to a successful outcome.

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Section: Animal Studiesmentioning

confidence: 82%

Section: Animal Studiesmentioning

confidence: 99%

Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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“…The well-reported model developed by Boden was used in this study [2]. This model provides an excellent preclinical evaluation of materials for spinal fusion and its usefulness is reflected in its wide acceptance.…”

Section: Discussionmentioning

confidence: 99%

“…Single-level posterolateral lumbar fusion was performed at L5-L6 in 69 adult New Zealand white rabbits as reported and developed by Dr. Boden et al [2] following institutional ethical approval. The study design is outlined in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Posterolateral spinal fusion in a rabbit model using a collagen–mineral composite bone graft substitute

et al. 2009

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Choosing the appropriate graft material to participate in the healing process in posterolateral spinal fusion continues to be a challenge. Combining synthetic graft materials with bone marrow aspirate (BMA) and autograft is a reasonable treatment option for surgeons to potentially reduce or replace the need for autograft. FormaGraft, a bone graft material comprising 12% bovine-derived collagen and 88% ceramic in the form of hydroxyapatite (HAp) and beta tricalcium phosphate (b-TCP) was evaluated in three possible treatment modalities for posterior spinal fusion in a standard rabbit model. These three treatment groups were FormaGraft alone, FormaGraft soaked in autogenous BMA, and FormaGraft with BMA and iliac crest autograft. No statistically demonstrable benefits or adverse effects of the addition of BMA were found in the current study based on macroscopic, radiology or mechanical data. This may reflect, in part, the good to excellent results of the collagen HA/TCP composite material alone in a well healing bony bed. Histology did, however, reveal a benefit with the use of BMA. Combining FormaGraft with autograft and BMA achieved results equivalent to autograft alone. The mineral and organic nature of the material provided a material that facilitated fusion between the transverse processes in a standard preclinical posterolateral fusion model.

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“…Data from animal studies would suggest that a bone graft substitute with some level of osteoinductivity is most effective for posterolateral spinal arthrodesis because it can combine the creeping substitution process of bone ingrowth from the decorticated host bone, with recruitment and differentiation of additional progenitor cells from the surrounding soft tissue adding a centripetal pattern of bone-healing 5,6 . Specific BMPs (BMP-2, 4, 6, 7, and 9) have demonstrated the potential for varying degrees of osteoinductivity 7 .…”

Section: Current Status Of Osteoinductive Agents For Spine Fusionmentioning

confidence: 99%