2011 AOA Symposium: Tissue Engineering and Tissue Regeneration

Rodeo, Scott A.; Boden, Scott D.; Murray, Martha M.; Einhorn, Thomas A.

doi:10.2106/jbjs.k.01505

Cited by 7 publications

(3 citation statements)

References 62 publications

(65 reference statements)

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“…The use of PRP to enhance bone regeneration was first proposed by Marx in 1998, when it was used to enhance healing of mandibular defects. 41 It has since been widely studied in other craniofacial applications, as well as orthopedic applications 2,22 including long bone fractures, 52 ligamentous repair, 48 intervertebral disk regeneration, 16,44,60 and spinal fusion. Additionally, it has been used to enhance fat grafting in reconstructive surgery with variable success.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion

et al. 2015

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Spinal fusion is one of the most commonly performed procedures for the treatment of spinal instability caused by a multitude of pathologies. However, despite significant advances in spinal instrumentation, failed fusion, or pseudoarthrosis, remains a significant challenge. Therefore, other additives such as bone graft extenders and growth factors have been explored as a method to augment fusion rates. Platelet-rich plasma (PRP) represents an additional approach, as it has shown some promise in bone regeneration. While the general use of PRP in orthopedic applications has been reviewed previously, its use in spinal fusion has not been systematically analyzed. The objective of this review is to systematically discuss the role of PRP in augmentation of bone regeneration for the purpose of spinal fusion. Background information on PRP, including a discussion of its preparation, activation, and growth factors, is included. Additionally, data from in vitro studies utilizing PRP in bone tissue engineering strategies is analyzed, and the available animal and clinical studies are systematically reviewed in order to provide guidance on future research pathways as well as the potential role of PRP in spinal fusion surgery.

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Section: Introductionmentioning

confidence: 99%

A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion

et al. 2015

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“…The increasing occurrence of bone disorders such as high-energy fractures, congenital deformities, osteomyelitis, osteometabolic diseases and neoplasms that require reconstructive surgical interventions, stimulated the search for new therapies considering the limitations of natural bone regeneration in situations with marked loss of bone mass [ 1 , 2 ]. The autologous graft remains the gold standard in reconstructive surgical treatments, as it presents characteristics of osteoinduction, osteogenesis and osteoconduction in the regenerative process.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Biological Behavior of Polymer Scaffolds of Natural Origin in the Bone Repair Process

et al. 2021

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Autologous bone grafts, used mainly in extensive bone loss, are considered the gold standard treatment in regenerative medicine, but still have limitations mainly in relation to the amount of bone available, donor area, morbidity and creation of additional surgical area. This fact encourages tissue engineering in relation to the need to develop new biomaterials, from sources other than the individual himself. Therefore, the present study aimed to investigate the effects of an elastin and collagen matrix on the bone repair process in critical size defects in rat calvaria. The animals (Wistar rats, n = 30) were submitted to a surgical procedure to create the bone defect and were divided into three groups: Control Group (CG, n = 10), defects filled with blood clot; E24/37 Group (E24/37, n = 10), defects filled with bovine elastin matrix hydrolyzed for 24 h at 37 °C and C24/25 Group (C24/25, n = 10), defects filled with porcine collagen matrix hydrolyzed for 24 h at 25 °C. Macroscopic and radiographic analyses demonstrated the absence of inflammatory signs and infection. Microtomographical 2D and 3D images showed centripetal bone growth and restricted margins of the bone defect. Histologically, the images confirmed the pattern of bone deposition at the margins of the remaining bone and without complete closure by bone tissue. In the morphometric analysis, the groups E24/37 and C24/25 (13.68 ± 1.44; 53.20 ± 4.47, respectively) showed statistically significant differences in relation to the CG (5.86 ± 2.87). It was concluded that the matrices used as scaffolds are biocompatible and increase the formation of new bone in a critical size defect, with greater formation in the polymer derived from the intestinal serous layer of porcine origin (C24/25).

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“…As médias e desvios-padrão do volume percentual relativo de osso neoformado no defeito craniano do grupo controle (G1), dos grupos enxertados com membrana de elastina 24h/37°C (G2 a G4) e dos grupos enxertados com membrana de serosa de intestino porcino 24h/25°C (G5 a G7), foram: 5, 86±2,87; 13,68±1,44; 17,65±1,85; 29,46±3,21; 53,20±4,46; 30,45±4,12; 38,47±5,32, respectivamente. Os biomateriais mostraramse biocompatíveis e o grupo 5 (G5-SIP24/25) apresentou a maior neoformação óssea. (RODEO et al, 2013;QUINNAN, 2017).…”

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Estudo comparativo de membrana serosa porcina e de elastina no reparo de defeitos na calvária de ratos

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2011 AOA Symposium: Tissue Engineering and Tissue Regeneration

Cited by 7 publications

References 62 publications

A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion

A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion

In Vivo Biological Behavior of Polymer Scaffolds of Natural Origin in the Bone Repair Process

Estudo comparativo de membrana serosa porcina e de elastina no reparo de defeitos na calvária de ratos

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