The use of a sulfadiazine-sulfathiazole mixture in the treatment of children

Lehr, David; Slobody, Lawrence B.; Greenberg, William M.

doi:10.1016/s0022-3476(46)80141-0

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…STZ–THE cocrystals exhibited a slightly higher solubility than the one of STZ crystals at the pH range from 3 to 6. The sulfonamide-induced crystalluria frequently occurred during the therapy of sulfonamide, which would cause the kidney lesions . The low solubility of sulfonamide in water is one of the reasons why it deposits in urine, so that the enhancement in its solubility should help to prevent crystalluria formation of sulfonamide .…”

Section: Results and Discussionmentioning

confidence: 99%

“…The sulfonamide-induced crystalluria frequently occurred during the therapy of sulfonamide, which would cause the kidney lesions. 30 The low solubility of sulfonamide in water is one of the reasons why it deposits in urine, so that the enhancement in its solubility should help to prevent crystalluria formation of sulfonamide. 31 At the pH range from 5.5 to 7, the solubility of STZ−THE cocrystals was higher than the one of STZ crystals.…”

Section: Crystal Growth and Designmentioning

confidence: 99%

“…It was reported that sulfonamide-induced crystalluria (i.e., sulfa drugs) in the urinary tract is highly dependent on the solubility and concentration of the sulfa drugs in the urine in the pH range of 5.5−7.0. 30,31 Therefore, the effect of pH on solubility for the cocrystals has been studied. In addition, the values of solubility, log P, and moisture stability for cocrystals have also been determined.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The percent yield and purity for the cocrystals of STZ–THE, and STZ–SNM, obtained by conventional methods and intensified processes have been compared for evaluating the feasibility of process intensification. It was reported that sulfonamide-induced crystalluria (i.e., sulfa drugs) in the urinary tract is highly dependent on the solubility and concentration of the sulfa drugs in the urine in the pH range of 5.5–7.0. , Therefore, the effect of pH on solubility for the cocrystals has been studied. In addition, the values of solubility, log P, and moisture stability for cocrystals have also been determined.…”

Section: Introductionmentioning

confidence: 99%

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Intensified Crystallization Processes for 1:1 Drug–Drug Cocrystals of Sulfathiazole–Theophylline, and Sulfathiazole–Sulfanilamide

Yeh

Lee

2018

Crystal Growth & Design

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The chemical synthesis and crystallization steps were integrated successfully for directly producing a 1:1 cocrystal of sulfathiazole−theophylline and a 1:1 cocrystal of sulfathiazole−sulfanilamide. The benefits of this process intensification were the reduction of number of steps, and the amount of energy consumption and solvent used. In addition, the overall cocrystal yields by Intensified Method I were much higher than the ones by the conventional method. Intensified Method I also gave highpurity cocrystals of ≥99%. Sulfathiazole not forming cocrystals with sulfanilamide by Intensified Method I was dissolved in the mother liquor by taking advantage of the pH-dependent solubility of sulfathiazole. Cocrystals of both sulfathiazole−theophylline and sulfathiazole−sulfanilamide systems remained stable under conditions of 40 °C and 75% relative humidity for a month.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Crystal Growth and Designmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations