The Solubility of Various Sulfonamides Emploved in Urinary Tract Infections**Research Laboratories, Flint, Eaton and Co., Decatur, Ill.

Anthraquinone-2,6-disulfamidic acid: an anolyte with low decomposition rates at elevated temperatures

“…The concept of using sulfamidic acids or sulfonamides as solubility enhancer in water represents a common strategy in the design process of new drugs. [21][22][23] We used this approach to enhance the solubility of anthraquinones with amino side groups. On the one hand, the oen applied 2,6-dihydroxy anthraquinone 24,25 can be substituted by the one order of magnitude cheaper 2,6-diamino anthraquinone and, on the other hand, sulfonamides are highly stable and cleavage or rearrangement reactions need drastic conditions and long reaction times.…”

Tailored‐design Synthesis of Sulfapyrimidine Derivatives

“…Both sulfamerazine ( B ) and sulfadimidine ( C ) (Figure ) are used in some acute bacterial infections such as Escherichia coli enteritis in veterinary medicine , cerebrospinal meningitis, and allergic reaction to penicillins . Sulfapyrimidine drugs with dimethyl groups such as sulfisomidine ( D ) (Figure ) are used for treatment of urinary infections because of their remarkable solubility in urine and absence of kidney damage . It is commonly used as a sulfa therapy in human serum hemolytic complement system .…”