The Undescended Testis in Adult Life

Ford, T. F.; Parkinson, M. C.; Pryor, John P.

doi:10.1111/j.1464-410x.1985.tb06417.x

Cited by 49 publications

(24 citation statements)

References 13 publications

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“…There is a suggestion from some studies that patients who undergo orchipexy before the age of 10 years have a relatively low risk of developing tumours compared with those who undergo correction later (Martin et al, 1979;Strader et al, 1988). It is for these reasons that some authors have recommended orchidectomy for unilateral undescended testis when diagnosed after puberty (Ford et al, 1985).…”

Section: Methods and Resultsmentioning

confidence: 99%

Germ cell tumours in uncorrected cryptorchid testis at Institute Rotary Cancer Hospital, New Delhi

Raina

Shukla²,

Gupta³

et al. 1995

Br J Cancer

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Suiamry Twenty-four out of 164 (14%) adult patients with pnrmary germ cell tumours of testis seen over the last 6 years at the Institute Rotary Cancer Hospital (IRCH) of the All India Institute of Medical Sciences (AIIMS), New Delhi, were found to have cryptorchidism. Only one patient had undergone correction. As a result the testes were intra-abdominal in the vast majority, and patients presented late. Twenty-two patients presented with stage Ilb or more advanced disease. Twelve patients had seminoma and the others had mixed or non-seminomatous germ cell tumour (NSGCT), i.e. 50% each. The earlier patients were managed by initial resection followed by radiation and or chemotherapy. As experience grew the seven patients who presented late were given initial chemotherapy followed by resection in those with residual tumours. The probability of overall survival was 0.65 at 36 months and, was not significantly different from survival in 114 patients with tumours of normally descended testis. Early orchipexy facilitates the detection, but whether it reduces the incidence of tumours is controversial. Uncorrected cryptorchidism is now rarely seen in the West, but in India and many other developing countries tumours of uncorrected cryptorchid testes continue to be seen.

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Section: Methods and Resultsmentioning

confidence: 99%

Germ cell tumours in uncorrected cryptorchid testis at Institute Rotary Cancer Hospital, New Delhi

Raina

Shukla²,

Gupta³

et al. 1995

Br J Cancer

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“…Data of 222 cases with known testicular volume, location and pathology results were evaluated separately from 97 cases with known semen analysis. Mean age of patients was 21.26±0.85 and median age was 21 (19)(20)(21)(22)(23)(24). Mean testicular volume of pathological specimens was 6.90±5.81 cc [median 6 cc (0.1-30)].…”

Section: Resultsmentioning

confidence: 99%

“…For this reason, orchiectomy is indicated in adult patients with cryptorchidism. [15][16][17][18][19] Although recently remarkable developments in the treatment of germ-cell neoplasia have been achieved, together with a decrease in disease-specific and perioperative mortality rates, orchiectomy can be performed in men up to 50 years of age with unilateral cryptorchidism. [20] In the literature, there are several studies about incidence of incidental tumor in adult patients with cryptorchidism who had undergone prophylactic orchiopexy for tumors.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathological results of the adult patients with unilateral cryptorchidism patients

Ateş

Soydan

Okçelik

et al. 2016

Turkish Journal of Urology

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Objective: To evaluate the clinical and histopathological results of adult unilateral cryptorchidism patients. Material and methods:Data from adult unilateral cryptorchidism patients that underwent orchiectomy in our clinic between between January 2004 and March 2013 were retrospectively evaluated. Patients were divided into three groups as intra-abdominal, inguinal canal and superficial inguinal region according to the location of the undescended testes. Patients were also grouped according to their testicular volume (<4 cc, 4.1-12 cc, and >12 cc). Histopathology results of orchiectomy specimens were classified as follows: 1. Sertoli cells only, testicular atrophy and vanished testis (anorchia) 2. Hypospermatogenesis, and 3. Maturation arrest. Patients were grouped as normospermia, azoospermia and oligo/astheno/teratospermia groups according to semen analysis results. Correlations between testicular localization, testicular size, semen analysis and pathology results were evaluated. Incidental tumor detection rates were also calculated.Results: Two hundred and forty-four adult unilateral cryptorchidism patients underwent orchiectomy in our clinic. There was no a significant relationship between location of the testis and testicular pathology results (p= 0.707). Most common semen analysis results was normospermia in patients with high testicular volume group however azoospermia and oligoasthenospermia observed commonly in patients with low testicular volume group. There was a significant relationship between testicular volume and semen analysis results (p= 0.023). No significant relationship was observed between semen analysis and pathological results (p= 0.929). After an evaluation of all factors with possible effects on the semen analysis results, only testicular volume (p= 0.036) was found to have a significant impact. Only one case (0.4%) was incidentally diagnosed seminoma after a review of 233 patients with available histopathological results on record. Conclusion:Adult unilateral cryptorchidism has a minimal effect on male fertility or even this effect can be overlooked. Low detection rates of incidental germ cell tumors also make an orchiectomy decision questionable in such cases.

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“…CIS was found in 4 of 16 intra-abdominal testes compared with 3 of 44 inguinal testes (7%). Ten of the 16 abdominal testes contained Sertoli cells only (Ford et al, 1985).…”

Section: Bilateralmentioning

confidence: 99%

Late Malignancy Risk in Urology

Woodhouse

1992

British Journal of Urology

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The long-term survival of children with congenital urological abnormalities is now taken for granted. In general, they have been found to grow up well after many operations and often in the face of considerable handicaps. Their survival carries with it numerous complications, the most frightening of which is the development of cancer. Successful treatment of congenital abnormalities does not excuse the patient from developing cancers to which the general population is prone, but some conditions and some treatments raise specific risks.

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The Undescended Testis in Adult Life

Cited by 49 publications

References 13 publications

Germ cell tumours in uncorrected cryptorchid testis at Institute Rotary Cancer Hospital, New Delhi

Germ cell tumours in uncorrected cryptorchid testis at Institute Rotary Cancer Hospital, New Delhi

Clinical and histopathological results of the adult patients with unilateral cryptorchidism patients

Late Malignancy Risk in Urology

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