The triglycerides and glucose index is associated with cardiovascular risk factors in normal-weight children and adolescents

Simental‐Mendía, Luis E.; Hernández-Ronquillo, Gabriela; Gómez-Díaz, Rita A.; Rodrı́guez-Morán, Martha; Guerrero‐Romero, Fernando

doi:10.1038/pr.2017.187

Cited by 30 publications

(14 citation statements)

References 38 publications

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“…In our study, we found similar cut-off values for boys and girls (8.38 vs 8.27). Moreover, similar cut-off values have been reached in a limited number of studies conducted in different countries (7.8-8.65) [15][16][17][18][19][20][21][22][23][24] . Moon et al 20 showed that 12-19 years old 8037 adolescents the cut-off values for the Ty-G index ranged from 8.15-8.65 in Mexican American, Non-Hispanic White, Korean, and Non-Hispanic Black adolescents.…”

Section: Discussionsupporting

confidence: 53%

“…Recently, emerged studies have shown that the Ty-G index can accept as a marker of IR, that is correlated with both the euglycemic clamp test and the HOMA-IR levels [7][8][9] There is a lot of study in adults investigating the Ty-G index [15][16][17][18] . However, a limited study in pediatric age group [19][20][21][22][23][24] . Moreover, to the best of our knowledge, there is no study on Turkish children.…”

Section: Discussionmentioning

confidence: 99%

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Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

TAŞTANOĞLU¹,

Çelik²

2021

Cumhuriyet Medical Journal

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There is a lot of study in adults investigating the Triglyceride-Glucose (Ty-G) index. However, a limited study has been searched in the pediatric age group. Moreover, to the best of our knowledge, there is no study on Turkish children. The aim of this study, to investigate the usability of the triglyceride-glucose index as an indicator of insulin resistance in obese adolescents and to calculate the cut-off values.Method: Six hundred twenty-three pubertal obese adolescents (266 boys, and 357 girls) were retrospectively evaluated. Ty-G index and HOMA-IR levels were calculated. ROC analysis was used for the estimations of the Ty-G index cutoff value.Results: There was positive correlation between HOMA-IR and Ty-G index in boys (r=0.255, p<0.001), in girls (r=0.402, p<0.001), and all study groups (r=0.323, p<0.001). Ty-G index cutoff value for insülin resistance in pubertal obese adolescents was calculated as 8.42 with 70.1 % sensitivity and 59.3 % specificity for all study groups; 8,38 with 71.1 % sensitivity, and 48.3 % specificity for boys; 8,27 with 80% sensitivity, and 52.9% specificity for girls.Conclusions: Ty-G index may be a reliable indicator for insülin resistance in pubertal obese adolescents. More attention should be given fort his marker with prospective studies.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

TAŞTANOĞLU¹,

Çelik²

2021

Cumhuriyet Medical Journal

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“…In addition, in the current study, the accumulation of cardiometabolic risk factors in children with high TyG index was higher in relation to the others. Simental-Mendía et al (39) , in a study with children and adolescents aged 6-15 years, observed that those distributed in the highest quintile of the TyG index had higher prevalence of cardiometabolic risk in relation to the others, suggesting a direct association between cardiovascular risk and the increased TyG index. Some positive points of the current study should be considered.…”

Section: Discussionmentioning

confidence: 97%

TAG–glucose (TyG) index in childhood: an estimate of cut-off points and the relation to cardiometabolic risk in 4- to 9-year-old children

Brito

Hermsdorff

Filgueiras

et al. 2020

Public Health Nutr.

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Objective: To propose cut-off points for the TAG–glucose (TyG) index in Brazilian children and evaluate the link to cardiometabolic risk. Design: A cross-sectional study with children from a municipality in Minas Gerais, Brazil. Anthropometric (weight, height, waist circumference and waist:height ratio), biochemical (lipid and glucose profile) and blood pressure (BP) tests were performed. Using the receiver operating characteristic curve, cut-off points for the TyG index were proposed according to sex using homoeostasis model of assessment – insulin resistance (IR) as the reference method. Setting: Viçosa, MG, Brazil. Participants: Children aged 4–9 years (n 515). Results: The TyG index cut-off points to identify the risk of IR were 7·9 and 8·1 for boys and girls, respectively. We observed that 48·7 % of the children had an increased TyG index. The increased TyG index was associated with overweight, total body and central fat, increased BP and altered lipid profile. Children with an increased TyG index had a higher accumulation of cardiometabolic risk factors. Conclusions: According to the cut-off points proposed by the current study, children at risk of IR estimated by the TyG index presented a higher cardiometabolic risk, including isolated risk factors, as to the higher accumulation of these.

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“…The TyG index has been shown to be clinically useful in the identification of the metabolic syndrome [ 97 , 98 ]. Increased TyG index has been associated with the presence of risk factors for cardiovascular disease in healthy children and adolescents with a normal body weight [ 99 ]. Lee et al, who tested the role of the TyG index in identifying MONW subjects, proposed a TyG cut-off value for MONW ≥ 8.82 for men and ≥8.73 for women [ 90 ].…”

Section: Biochemical Markers In Monwmentioning

confidence: 99%

Metabolic Obesity in People with Normal Body Weight (MONW)—Review of Diagnostic Criteria

Pluta

Dudzińska

Lubkowska

2022

IJERPH

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Disorders of metabolic obesity with normal body weight (MONW) are widely recognized risk factors for the development of cardiovascular diseases and type 2 diabetes. Despite this, MONW is not diagnosed in clinical practice. There is no consensus on the definition of MONW, and measuring the degree of insulin resistance or obesity among apparently healthy, non-obese patients is not widely applicable. The awareness of the relationship between metabolic disorders such as MONW and a higher risk of mortality from cardiovascular causes and other related diseases prompts the need for action to be taken aimed at creating appropriate diagnostic models that will allow for the effective detection of those with metabolic abnormalities among people with normal body weight. Such actions are decisive in the prevention and treatment of diseases. Therefore, the purpose of this article is to review the MONW diagnostic criteria used over the years.

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The triglycerides and glucose index is associated with cardiovascular risk factors in normal-weight children and adolescents

Cited by 30 publications

References 38 publications

Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

Triglyceride-Glucose Index As a Surrogate Marker for Insulin Resistance ın Obese Adolescents

TAG–glucose (TyG) index in childhood: an estimate of cut-off points and the relation to cardiometabolic risk in 4- to 9-year-old children

Metabolic Obesity in People with Normal Body Weight (MONW)—Review of Diagnostic Criteria

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