TAG–glucose (TyG) index in childhood: an estimate of cut-off points and the relation to cardiometabolic risk in 4- to 9-year-old children

Abstract

Objective: To propose cut-off points for the TAG–glucose (TyG) index in Brazilian children and evaluate the link to cardiometabolic risk. Design: A cross-sectional study with children from a municipality in Minas Gerais, Brazil. Anthropometric (weight, height, waist circumference and waist:height ratio), biochemical (lipid and glucose profile) and blood pressure (BP) tests were performed. Using the receiver operating characteristic curve, cut-off points for the TyG index were proposed according to sex using homoeostasis model of assessment – insulin resistance (IR) as the reference method. Setting: Viçosa, MG, Brazil. Participants: Children aged 4–9 years (n 515). Results: The TyG index cut-off points to identify the risk of IR were 7·9 and 8·1 for boys and girls, respectively. We observed that 48·7 % of the children had an increased TyG index. The increased TyG index was associated with overweight, total body and central fat, increased BP and altered lipid profile. Children with an increased TyG index had a higher accumulation of cardiometabolic risk factors. Conclusions: According to the cut-off points proposed by the current study, children at risk of IR estimated by the TyG index presented a higher cardiometabolic risk, including isolated risk factors, as to the higher accumulation of these.

Association of long-term triglyceride-glucose index level and change with the risk of cardiometabolic diseases

“…IR is widely known as a primary risk factor for T2DM and CVD, and associated with metabolic abnormalities ( 7 , 8 , 26 ). On account of the complex detection process and the clinical complexity, the hyperinsulinemic euglycemic glucose clamp (HEGC), which was considered as the gold standard for IR assessment ( 27 ).…”

“…The existing robust epidemiological evidence implies that insulin resistance (IR), which has been recognized as an independent risk factor, contributes to the initiation and perpetuation of CMDs ( 7 , 8 ). Nevertheless, the TyG-index, known as an alternative method for measuring IR ( 9 – 11 ), could be applied for clinical purposes and has shown a significant relation with IR ( 12 , 13 ).…”

A population-based study of TyG index distribution and its relationship to cardiometabolic risk factors in children and adolescents

“…The TyG index is significantly associated with the presence of T2DM, nonalcoholic fatty liver disease (NAFLD), and MetS in adults and is a better predictor of IR than HOMA-IR 14 – 18 . Recent studies have reported that the TyG index can predict the presence and progression of coronary artery calcification (CAC) in adults and is associated with cardiovascular risk factors in children and adolescents 19 – 22 . Cutoff points for the TyG index for MetS and cardiometabolic risk have been suggested in many studies of children and adolescents, and the usefulness of screening has been sufficiently emphasized 22 – 25 .…”

“…Recent studies have reported that the TyG index can predict the presence and progression of coronary artery calcification (CAC) in adults and is associated with cardiovascular risk factors in children and adolescents 19 – 22 . Cutoff points for the TyG index for MetS and cardiometabolic risk have been suggested in many studies of children and adolescents, and the usefulness of screening has been sufficiently emphasized 22 – 25 . For the TyG index to be useful in clinical practice, it is necessary to determine its association with various confounding factors and whether it is consistently distributed in children and adolescents; however, studies on these characteristics are still lacking.…”

TyG Index Distributions and Relationship to Cardiometabolic Risk Factors in Children and Adolescents: A Population-Based Study

“…The TyG index is signi cantly associated with the presence of T2DM, nonalcoholic fatty liver disease (NAFLD), and MetS in adults and is a better predictor of IR than HOMA-IR [14][15][16][17][18] . Recent studies have reported that the TyG index can predict the presence and progression of coronary artery calci cation (CAC) in adults and is associated with cardiovascular risk factors in children and adolescents [19][20][21][22] . In many studies in children and adolescents, cutoff points for the TyG index for MetS and cardiometabolic risk have been suggested, and its usefulness has been su ciently emphasized.…”