The treatment of split thickness skin graft donor sites using n-butyl and n-heptyl 2-cyanoacrylate

Ousterhout, Douglas K.; Tumbusch, Wilfred T.; Margetis, Peter M.; Leonard, Fred

doi:10.1016/s0007-1226(71)80006-1

Cited by 9 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cyanoacrylates (CA) were developed in 1949 1 and first used as medical tissue adhesives by Coover et al in 1959 2 . The butyl‐cyanoacrylates have been used for more than 4 decades in Europe, Canada, and Israel with great success, mostly for closing lacerations and surgical incisions 3–7 . The widespread use of butyl‐cyanoacrylate has been limited by its low tensile strength and nonflexible, brittle nature.…”

mentioning

confidence: 99%

Evaluation of a new liquid occlusive dressing for excisional wounds

Singer¹,

Nable

Cameau³

et al. 2003

Wound Repair Regeneration

View full text Add to dashboard Cite

We evaluated a novel octylcyanoacrylate-based liquid occlusive dressing for partial-thickness wounds. One hundred and fifteen standardized wounds were created with an electric dermatome set at a depth of 600 micro on the flanks of three pigs and randomly treated with liquid occlusive dressing, a hydrocolloid dressing, or gauze. In one pig, wounds were swabbed with Staphylococcus aureus. Biopsies were taken after 4, 5, 6, and 21 days. Hemostasis was obtained in all wounds treated with the liquid occlusive. The percent reepithelialization of wounds treated with the liquid occlusive and hydrocolloid dressings were significantly greater at days 4 and 5 than control wounds (78% and 82% vs. 40%, p < 0.001 and 99% and 100% vs. 72%, p < 0.001, respectively). None of the liquid occlusive-treated wounds challenged with bacteria became infected. Foreign body reactions were least common in wounds treated with the liquid occlusive (p < 0.001). Scar depth was less for liquid occlusive- and hydrocolloid-treated wounds than controls (285 micro and 303 micro vs. 490 micro, p < 0.001). We conclude that excisional wounds treated with the liquid occlusive dressing reepithelialize as quickly as hydrocolloid-treated wounds. The liquid occlusive dressing is an effective microbial barrier and hemostatic agent resulting in fewer foreign body reactions than hydrocolloid-treated wounds or controls.

show abstract

mentioning

confidence: 99%

Evaluation of a new liquid occlusive dressing for excisional wounds

Singer¹,

Nable

Cameau³

et al. 2003

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…Bhaskar et al 3 were successful in applying 2‐BCA to the raw surfaces of postgingivectomy wounds in human beings without substantial FBGRs. Ousterhout et al 4 applied 2‐BCA to the donor site of a split‐thickness skin wound and compared it with fine‐meshed gauze. He noted only minimal FBGR in the 2‐BCA‐treated donor wounds.…”

Section: Discussionmentioning

confidence: 99%

Securing meshed split‐thickness skin grafts with 2‐octylcyanoacrylate

Tamez

McGuff

Prihoda

et al. 1999

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Meshed split-thickness skin grafts (STSGs) secured with 2-octylcyanoacrylate (2-OCA) were compared with meshed STSGs secured by suture and bolster (S&B). The 2 techniques were compared for graft survival, foreign-body giant cell response, inflammatory response, appearance, texture, and application time. Sixteen 2.5 x 2. 5 cm meshed STSGs were harvested from the dorsa of 2 pigs for a total of 32 grafts. On each pig 8 grafts were sprayed with 2-OCA, and the other 8 were secured with S&B. Evaluations were performed on postoperative days 14, 24, 48, and 56. Biopsy specimens were obtained on postoperative days 14 and 56. There were no significant differences in percent survival, foreign-body giant cell response, inflammatory response, and appearance between control and study grafts. The average time to apply the 2-OCA onto a graft was 3 seconds, compared with 8 minutes for S&B application. 2-OCA provides a quick and reliable means of securing meshed STSGs and would be especially useful in areas where it is difficult to use S&B, such as total maxillectomy defects.

show abstract

Tissue Adhesives in Cutaneous Surgery

Wilkinson¹

1972

Arch Dermatol

View full text Add to dashboard Cite

The treatment of split thickness skin graft donor sites using n-butyl and n-heptyl 2-cyanoacrylate

Cited by 9 publications

References 9 publications

Evaluation of a new liquid occlusive dressing for excisional wounds

Evaluation of a new liquid occlusive dressing for excisional wounds

Securing meshed split‐thickness skin grafts with 2‐octylcyanoacrylate

Tissue Adhesives in Cutaneous Surgery

Contact Info

Product

Resources

About