Evaluation of a new liquid occlusive dressing for excisional wounds

Singer, Adam J.; Nable, Maria; Cameau, Paul; Singer, Daniel; McClain, Steve A.

doi:10.1046/j.1524-475x.2003.11306.x

Cited by 29 publications

(17 citation statements)

References 38 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, frequent dressing changes would no longer be an advantage when reapplication of the OCA was required. The results of our study are in contrast with those involving superficial abrasions in humans 16 and animals, 14,15 and noncontaminated 10,12 and contaminated 11 burns in a porcine model. The failure of the OCA adhesive to perform consistently in human burns is probably explained by the presence of a large amount of weeping and exudates typical of superficial, partialthickness (second-degree) burns.…”

Section: Discussioncontrasting

confidence: 94%

“…13 Singer et al reported similar results after treating deep, partial-thickness excisional wounds with OCA in a porcine model. 14 Davis et al found that small, superficial, partialthickness porcine wounds treated with a slightly different and weaker version of a liquid OCA healed faster than those treated with a hydrocolloid dressing. 15 An OCA-based liquid bandage has also been shown to reduce pain and bleeding while resulting in healing similar to that with standard bandages in patients with minor cuts and scrapes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

Singer

Soroff

Brebbia

2005

Academic Emergency Medicine

View full text Add to dashboard Cite

Background: Octylcyanoacrylate (OCA) is a tissue adhesive used to close wounds and to treat minor abrasions. Objective: To explore the use of OCA in patients with superficial, partial-thickness burns. Methods: A prospective, noncomparative, pilot study was conducted in an emergency department (ED) and burn center. Consecutive patients with early (,6 hours), small (,5% total body surface area [TBSA]), superficial, partial-thickness burns were enrolled. Burns were cleaned and any nonadherent necrotic epidermis was removed. Tense blisters were aseptically aspirated. Burns were then covered with a liquid OCA that was applied with a sponge brush. Pain of cleansing and OCA application was recorded, and physicians assessed ease of application. Burns were evaluated every one to two days until complete epithelialization for the presence of infection and exudation, and the OCA was reapplied as necessary. Main outcomes measured were the need for additional topical therapy, pain and ease of application, patient comfort, and satisfaction. Results: Ten patients were enrolled. Mean patient age (6 standard deviation [SD]) was 23 (616) years, four were female, and nine were white. Burns were located on the hands (5),

show abstract

Section: Discussioncontrasting

confidence: 94%

mentioning

confidence: 99%

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

Singer

Soroff

Brebbia

2005

Academic Emergency Medicine

View full text Add to dashboard Cite

show abstract

“…They also found that only 2-octyl cyanoacrylate provided complete hemostasis, reduced scab formation, and did not induce an irritant response or infection. Singer et al [25] evaluated a stronger 2-octyl cyanoacrylate formulation for the treatment of larger and deeper (0.6 mm) excisional wounds in swine. They found that the rates of re-epithelialization of 2-octyl cyanoacrylate treated wounds were similar to wounds treated with hydrocolloid and better than those treated with dry gauze.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of 2-Octyl Cyanoacrylate Adhesives versus Conventional Suture Materials for Eyelid Wound Closure in Rabbits

Ahn

Shin

Roh

et al. 2011

Korean J Ophthalmol

View full text Add to dashboard Cite

PurposeTo evaluate the clinical efficacy and histopathological tolerance of 2-octyl cyanoacrylate versus conventional suture materials for eyelid wound closure in rabbits.MethodsWe performed an experimental study on 16 eyes of eight New Zealand albino rabbits. Eyelid incisions of 15 mm were done 4mm from the upper eyelid margin in both eyes. The eyes of the rabbits were divided into two groups: eyelid incisions of the right eye were closed by a 2-octyl cyanoacrylate adhesive (group A) and eyelid incisions of the left eye were closed by 7-0 nylon sutures (group B). At 1, 2, 4, and 8 weeks after surgery, the rabbits were macroscopically examined and then sacrificed. The specimens of their eyelid tissues were stained by a hematoxylin and eosin stain and Masson-trichrome stain, and were observed under microscope.ResultsBoth eyelid surgical closure methods were found to be equally efficacious in fixing the eyelids of groups A and B, and their clinical efficacy was similar. Histopathological findings of the hematoxylin and eosin stain of group A showed less inflammatory infiltration than group B at 2 weeks. There were no significant histopathological differences between the two groups at 1, 4, and 8 weeks. The degree of fibrosis of the Masson-trichrome stain was similar between the two groups at 8 weeks.ConclusionsThe 2-octyl cyanoacrylate adhesive proved to be an effective eyelid closure method and was very well tolerated by the skin surface. 2-Octyl cyanoacrylate could be used as an alternative tissue adhesive for eyelid wound closure along with conventional suture materials.

show abstract

“…Middelkoop et al developed an excisional model for testing dermal and epidermal substitutes and for scald and contact burns [2] which favored a burn size of approximately 50 cm 2 . Several porcine burn models, detailed descriptions of burn depth and scar assessments, and dressing application methods have been published by Singer et al [3-5,20,21]. Mittermayr et al [22] developed a pig model of excision and grafting with non-meshed skin autograft and performed wound healing measurements for 2 weeks.…”

Section: Discussionmentioning

confidence: 99%

A porcine model of full-thickness burn, excision and skin autografting

Branski¹,

Mittermayr²,

Herndon³

et al. 2008

Burns

111

View full text Add to dashboard Cite

Acute burn wounds often require early excision and adequate coverage to prevent further hypothermia, protein and fluid losses, and the risk of infection. Meshed autologous skin grafts are generally regarded as the standard treatment for extensive full-thickness burns. Graft take and rate of wound healing, however, depend on several endogenous factors. This paper describes a standardized reproducible porcine model of burn and skin grafting which can be used to study the effects of topical treatments on graft take and re-epithelialization.Procedures provide a protocol for successful porcine burn wound experiments with special focus on pre-operative care, anesthesia, burn allocation, excision and grafting, postoperative treatment, dressing application, and specimen collection. Selected outcome measurements include percent area of wound closure by planimetry, wound assessment using a clinical assessment scale, and histological scoring.The use of this standardized model provides burn researchers with a valuable tool for the comparison of different topical drug treatments and dressing materials in a setting that closely mimics clinical reality. KeywordsBurn; Burn excision; Wound healing; Reconstruction; Autograft BackgroundStandard treatment for severe burns currently includes early excision and adequate coverage to prevent hypothermia, protein and fluid loss, and risk of exogenous infection [1]. Autologous meshed split-thickness skin grafts are generally regarded as the standard treatment for extensive full-thickness burns. Early wound healing with concomitant wound closure is a major factor in patient outcome and infection control.To determine new treatment options which enhance and accelerate wound healing, many investigators rely on animal models to closely observe the healing process. Many animal models have been described in the literature, mostly involving rodents and pigs, with different *Corresponding author. Tel.: +1 409 770 6742; fax: +1409 770 6919. E-mail address: majeschk@utmb.edu (M.G. Jeschke). 1 Authors contributed equally to this manuscript. [2][3][4][5][6]. However, there has been no large animal model described which would encompass a burn excision and autografting, for an extended observation of over 2 weeks, to closely monitor the wound healing progress and its mechanisms. This paper presents a porcine model for the assessment of multiple treatments and quantification of differences in burn wound healing. Conflict of interest statement Procedures Basic and study guidelinesPigs have been used as models for wound healing studies due to their structural and functional resemblance to human skin. The thickness of porcine skin differs greatly depending on the location (pig epidermis: 30-140 μm; Human epidermis: 50-120 μm) [7]. Further, the vascularization of human and porcine skin is similar [8], with both human and pig having about 95% collagen and 2% elastic fibers in their extracellular matrix. This composition presents similar elastic components which is paramount in wound contraction [9]....

show abstract

Evaluation of a new liquid occlusive dressing for excisional wounds

Cited by 29 publications

References 38 publications

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

Octylcyanoacrylate for the Treatment of Small, Superficial, Partial-thickness Burns: A Pilot Study

A Comparison of 2-Octyl Cyanoacrylate Adhesives versus Conventional Suture Materials for Eyelid Wound Closure in Rabbits

A porcine model of full-thickness burn, excision and skin autografting

Contact Info

Product

Resources

About