The treatment of benign chronic bullous dermatosis of childhood, and dermatitis herpetiformis and bullous pemphigoid beginning in childhood*

Epidermolysis Bullosa Acquisita in an 8‐year‐old Girl

“…On immunoelectron microscopy, IgG is deposited at the lamina lucida within the basement membrane zone (16). Childhood bullous pemphigoid responds in a variable manner to sulfones and oral steroids (17). Our patient with epidermolysis bullosa acquisita had none of the above features with the exception of positive direct immunofiuorescence for IgG.…”

Mixed immunobullous disease of childhood: a good response to antimicrobials

“…6,7 In BP, linear IgG is found at the BMZ and treatment with systemic steroids is nearly always required to achieve control. Firstline treatment is dapsone or sulphapyridine, with the addition of systemic steroids if required.…”

“…Firstline treatment is dapsone or sulphapyridine, with the addition of systemic steroids if required. 6,7 In BP, linear IgG is found at the BMZ and treatment with systemic steroids is nearly always required to achieve control. 8 Results from the 62 patients with a single antibody response have confirmed these findings in CBDC and BP ( Table 2).…”

Bullous pemphigoid in a child

“…Large doses of prednisolone (30-120 mg daily) are often required to control the disease (Bean et al, 1970;Fincher et al, 1971;Esterly et al, 1973;Robison & Odom, 1978;Chorzelski & Jablonska, 1979) and one of our patients needed as much as 500 mg prednisolone daily (Skeete & Greaves, 1976). However, spontaneous remissions may occur (Robison & Odom, 1978;Piamphongsant, Chaikittisilpa & KuUivanijaya, 1977) and in some cases the eruption can be controlled by either dapsone or sulphapyridine alone (Piamphongsant et al, 1979;Marsden, 1982). The patient described here has been kept virtually free of lesions for almost 10 months by moderate doses of prednisolone and sulphapyridine and up to now has shown no adverse effects from treatment.…”