Bullous pemphigoid in a child

Marsden, R.A.

doi:10.1111/j.1365-2230.1983.tb01788.x

Cited by 19 publications

(5 citation statements)

References 16 publications

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“…Even though bullous pemphigoid is seen mostly in elderly patients, it does occur in children (1)(2)(3)(4)(5)(6)(7). It is manifested clinically as builae, which can be surrounded by normal or erythematous skin.…”

Section: Discussionmentioning

confidence: 99%

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Localized Vulvar Pemphigoid in a Child

DeCastro

Jorizzo²,

Rajaraman

et al. 1985

Pediatric Dermatology

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Bullous pemphigoid often affects the elderly but is not common in children. At least two localized variants, cicatricial pemphigoid and localized, chronic pemphigoid of Brunsting-Perry, have been described. A case of bullous pemphigoid in a 9-year-old girl was unusual because erosions were limited to the vulvar area. Other bullous dermatoses were considered in the differential diagnosis. Histopathologic examination and immunofluorescence microscopic studies, as well as immunoelectron microscopic studies, which yielded unique results, were performed to confirm the diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Bullous pemphigoid affects the elderly, although it may be seen in children (1)(2)(3)(4)(5)(6)(7). At least two localized variants have been described (5)(6)(7)(8): cicatriciai pemphigoid, which affects mucosal surfaces, and the localized chronic pemphigoid of Brttnsting-Perry, which is generally limited to the head and neck.…”

mentioning

confidence: 99%

Localized Vulvar Pemphigoid in a Child

DeCastro

Jorizzo²,

Rajaraman

et al. 1985

Pediatric Dermatology

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“…Corticosteroid therapy was effective in 8 cases, 2-4,11,13-16 6 cases were successfully treated with a combination of corticosteroid and dapsone, 17-21 and 4 cases with a combination of corticosteroid and sulfapyridine. 1,12,22,23 Two cases were cured with sulfapyridine alone. 24,25 Other drugs used in combination with systemic corticosteroids include erythromycin, nicotinamide, or mycophenolate mofetil.…”

Section: Discussionmentioning

confidence: 98%

Infantile bullous pemphigoid treated with intravenous immunoglobulin therapy

Sugawara

Nagai

Matsushima

et al. 2007

Journal of the American Academy of Dermatology

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“…To our knowledge, 10 previous cases of bullous pemphigoid in children aged 1 year or younger have been reported (see Table 1). All infants had bullae either confined to palms and soles or accentuated on palms and soles, and mucous membrane involvement has been seen in only one infant (1)(2)(3)(4)(5)(6)(7)(8)(9). A 4-month-old male infant was reported who developed bullous pemphigoid 5 hours after receiving his DPT and polio vaccinations (6).…”

Section: Discussionmentioning

confidence: 99%

Bullous Pemphigoid in Infancy: Case Report and Literature Review

Amos

Deng

Flynn

et al. 1998

Pediatric Dermatology

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We report a 2-month-old girl who developed bullous pemphigoid on her hands and feet shortly after receiving her routine immunizations. Infantile bullous pemphigoid has a clinical presentation distinct from bullous pemphigoid seen in older children and should be included in the differential diagnosis of blisters involving the hands and feet. Our patient responded well to topical corticosteroid therapy. CASE REPORTA 3-month-old healthy white female infant presented to the dermatology clinic with a 1 month history of blisters which began on her feet. The blisters developed 3 days after she received her routine 2 month immunizations (oral polio, diphtheria-tetanus-pertussis (DPT), hemophilus type B, and hepatitis B). The blisters had been increasing in both number and size and had spread to the patient's hands. She had no prior history of skin disorders and no family history of atopy. Physical examination revealed a well-appearing infant girl who was noted to have multiple 0.25 to 1 cm tense bullae on erythematous bases (Fig. 1). The lesions were clustered most intensely on the ventral surfaces of the palms and soles, but also were present on the lateral digits and the dorsal hands and feet. Solitary lesions were also noted on her arms and legs. No lesions were noted on the patient's trunk, face, or perineum.Punch biopsies were performed of the lesional and perilesional skin from the dorsal right foot for both standard histologic analysis and for immunofluorescence studies. Laboratory evaluation including a complete blood count with differential was within normal limits, with the exception of a mild peripheral eosinophilia (8%). Hematoxylin and eosin staining clearly demonstrated a subepidermal bullous dermatosis with an intense mixed inflammatory infiltrate containing numerous eosinophils within the dermis.Periodic acid-Schiff stain for fungi was negative. Gram's stain was negative. Direct immunofluorescence of perilesional skin revealed linear staining of IgG along the basement membrane zone (Fig. 2). Staining of complement component C3 was also seen in the same distribution. Staining for IgA, IgM, and fibrinogen was negative, and no circulating antibasement membrane zone antibodies were detected in the patient's serum. The mother's serum was tested and found to be devoid of circulating antibasement membrane zone antibodies. Neither salt-split skin testing or immunoblot assay was performed. After a potent topical steroid (Cyclocort ointment) was applied, her blisters resolved completely at 6 weeks with only mild postinflammatory hyperpigmentation and no textural changes. One year after resolution of her lesions the patient has had no further outbreaks and has continued the recommended schedule for routine childhood immunizations.

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Bullous pemphigoid in a child

Cited by 19 publications

References 16 publications

Localized Vulvar Pemphigoid in a Child

Localized Vulvar Pemphigoid in a Child

Infantile bullous pemphigoid treated with intravenous immunoglobulin therapy

Bullous Pemphigoid in Infancy: Case Report and Literature Review

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