Localized Vulvar Pemphigoid in a Child

Abstract

Bullous pemphigoid often affects the elderly but is not common in children. At least two localized variants, cicatricial pemphigoid and localized, chronic pemphigoid of Brunsting-Perry, have been described. A case of bullous pemphigoid in a 9-year-old girl was unusual because erosions were limited to the vulvar area. Other bullous dermatoses were considered in the differential diagnosis. Histopathologic examination and immunofluorescence microscopic studies, as well as immunoelectron microscopic studies, which yielded unique results, were performed to confirm the diagnosis.

Localized Bullous Pemphigoid of the Vulva

“…An isolated infestation of genital lesions by non-scarring bullous pemphigoid is also a rare condition; only a few cases have been reported (4)(5)(6)(7)(8)(9). Here I report an additional case of localized vulvar pemphigoid.…”

Atypical presentations of bullous pemphigoid: Clinical and immunopathological aspects

“…Vulvar BP, instead, is exclusively localized and confined to the vulva, with self-limited, non-scarring lesions. It is a rare variant of BP; to our knowledge there are 15 cases in the literature to date [53,[56][57][58][59][60][61][62][63][64][65][66]. Most cases are described in children [56,67] but a few cases regard older women as well [59].…”

Pemphigoid in Children

“…The published cases of CP and JLP are listed in Table 2, Ten cases of CP have been described in children (7 giris and 3 boys) and two of vulvar JLP, both possibly cicatricial, have been reported in girls aged 8 and 10 years (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32),…”

“…This percentage is higher than that given in various studies of adults, which ranges from 8% to 39% (1), This self-limited disease lasts for years, with exacerbations and remissions. Almost all juvenile cases are disseminated, although there is doubt about the final diagnosis in the two patients with localized disease, who clinically had some similarities to the cicatriciai form (22,30), No patient had a history or clinical indication of malignant disease, a controversial association in adults.…”

“…Juvenile localized pemphigoid has been described in only two chiidren and was localized to the vulva in both (20,30). Clinically, there were erosions and buliae in the vulval area.…”