1986
DOI: 10.1111/j.1525-1470.1986.tb00532.x
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Epidermolysis Bullosa Acquisita in an 8‐year‐old Girl

Abstract: Epidermolysis bullosa acquisita is an autoimmune blistering disease with the distinct feature of having an autoantibody directed against an antigen located below the basement membrane of human skin and mucous membrane. We identified this disease in an 8-year-old girl, the youngest patient documented by immunoelectron microscopy.

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Cited by 28 publications
(20 citation statements)
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References 25 publications
(36 reference statements)
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“…Indirect immunofluorescence on salt‐split skin showed IgG deposits at the dermal side of the cleavage favoring the diagnosis of EBA and a common finding in all 30 EBA cases already reported (420).…”
Section: Discussionsupporting
confidence: 57%
See 1 more Smart Citation
“…Indirect immunofluorescence on salt‐split skin showed IgG deposits at the dermal side of the cleavage favoring the diagnosis of EBA and a common finding in all 30 EBA cases already reported (420).…”
Section: Discussionsupporting
confidence: 57%
“…Mucosal involvement, especially of the oral cavity, is observed in childhood EBA (46, 8, 10, 1216). Sixteen out of the 30 cases reported in children have presented with oral lesions; the genital area was affected in seven, and ocular involvement leading to blindness was present in one case (13).…”
Section: Discussionmentioning
confidence: 99%
“…The classical type presents with marked skin fragility, blisters and erosions at sites of trauma, and heals with scarring and milia. The inflammatory type can mimic almost all other chronic bullous diseases, and its clinical differentiation from BP, cicatricial pemphigoid and linear IgA bullous dermatosis may be difficult 4–6,9–26 . In some patients, characteristics of both classical and inflammatory phenotypes of EBA have been observed, 9 but most patients with EBA in adulthood appear to have the classical type of EBA.…”
Section: Discussionmentioning
confidence: 99%
“…[3][4][5][6][7][8] Epidermolysis bullosa acquisita in childhood 39 The age of onset ranges from 3 months to 12 years. Of 13 cases, there were nine girls and four boys.…”
Section: Discussionmentioning
confidence: 99%
“…Of 13 cases, there were nine girls and four boys. [3][4][5][6][7][8][9] Delay in diagnosis and treatment has been a problem because of incorrect assessment. Clinical subdivisions of epidermolysis bullosa acquisita have been based on adult patterns, although children seem to have more inflammatory disease.…”
Section: Discussionmentioning
confidence: 99%