The Transplantation of Human Carcinomatous Material Into Lower Animals

Abstract

Although many attempts have been made to inoculate successfully ,the lower animals with portions of tumors from human beings they 'have in the great majority of cases been without results. In some instances the observers have claimed that they have been successful }rot their statements are, as a rule, not convincing.Carl Lewin 1 discusses this question of transplantation at length and reviews the reports of those who have conducted such experiments. The following is a synopsis of the instances that he considers, separating them into two groups, according as the results of the transplantation were negative or apparently successful.The first to be given are the negative instances.Doutrelepont ~ experimented with the transplantation of human tissue into the lower animals with negative results.BiIlroth 3 attempted to transfer human carcinoma and round cell sarcoma to dogs. No growth was however, obtained either by implantation or by injection into the jugular vein. Lebert and Wyss * injected a sarcoma emulsion into rabbits without any growth taking place. FischP injected rats intraperitoneally, intravenously and subcutaneously with a small cell sarcoma of the upper arm and with a melano-sarcoma of the lymph nodes. The tumors were absorbed without leaving the slightest trace.Duplay and Cazin" and Pawlowsky 7 transplanted sarcomatous tissue with no resulting growth. Roux and Metschnikoff s inoculated portions of a melano-sarcoma into the anterior chamber of the eye, and also beneath the skin of a young chimpanzee, with negative results.

Tissue Recombination Models for the Study of Epithelial Cancer

“…Attempts to inoculate experimental animals with representative fragments of human tumors have been recorded since the mid-1800s (McConnell 1908;Woolley 1958). Although there were a few examples of successful heterotransplantation, the vast majority of these early studies ended up with negative results (McConnell 1908). Immune responses associated with the heterologous transfer of human tissues are the predominant mechanism for the rejection of transplanted grafts.…”